Search review questions

Overweight/obesity risk · Healthy children aged 6–24 months in Western industrialized countries · 24 months, BLISS RCTs

Caries severity (mean DMFT) · 12-year-old children (permanent dentition) in Africa · Data collection period: 2005-2009

Food purchasing · Vote counting by direction of effect; clear association of public health harm

Restoration failure · Children with carious primary teeth · 1 year, Class II

Difference in summary specificity (NMA, Analysis 2) · Transillumination vs Visual

Chronic herpes simplex infection prevalence · Children and adolescents (<18 years) living with HIV (CLWH)

Treatment failure (annual failure rate) · Children with previously unrestored, vital carious lesions in primary teeth (no pulp therapy); aged 1.5-11 years · 12 months (El-Housseiny 2019)

Caries arrest · Children (age 1-10 years) with active cavitated dentin caries lesions in primary molars · Follow-up up to 12 months (single application), SDF application frequency: single (one-time) application

Mineral loss (transversal microradiography) · Enamel/dentin specimens with initial caries lesions (or sound surfaces) in intraoral (in situ) appliances worn by… · Median 21 days (range 14-28 days), Net-remineralizing conditions

Dental caries detection accuracy · Dental images of human beings · Geetha et al., 2020; backpropagation

Caries incidence in first permanent molars · Schoolchildren aged 6-12 years with sound occlusal surfaces of the first permanent molars · 24 months

Contribution of dental care products to total daily fluoride intake (TDFI), by tap-water fluoride level · Adults using fluoride-containing dental care products (two included studies [28,47]; aged 20-35) · Habitual daily intake, Low-fluoridated tap water (0.3-0.51 mg/L)

Early childhood caries (ECC) - association with genetically predicted expression of LINC02905 (C8orf49) (chr8p23.1) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5… · Cross-sectional (ECC ascertained at the last dental exam before age 6), LINC02905 (C8orf49) (chr8p23.1); 9 (3) tissues; significant (Bonferroni p < 3.09x10-6) ; flagged possible false positive

Oral health-related quality of life · Children with dental caries · Network estimate

Retention of sealant (complete or partial retention) · 'Healthy' children with caries-free second primary molars, aged 3-5 years (schools and kindergartens, India and China) · 24 months

Caries severity (mean DMFT) · 12-year-old children (permanent dentition) in Africa · Country: Burkina Faso

Restoration failure · Children with carious primary teeth · 1.5 years, Class II

Caries experience at the tooth level (dmft) · Children (mean age newborn to ~5.2 years) and their parents/carers

Dental caries measured by net increment in DMFT scores · Primary school children (aged 3-16 years) attending primary school in low- and middle-income countries (LMICs) · Post-intervention; follow-up varied across studies (interventions ranged from <2 years to >=2 years and longer), Age 9-12 years

Access to/visited dental services prevalence · Children in low- and middle-income countries (both with and without dental caries)

Caries prevalence · 12-year-old children (permanent dentition) in Africa · Data collection period: >2015

Caries arrest rate (absolute proportion of lesions arrested) · Children (age 1-10 years) with active cavitated dentin caries lesions in primary molars · Follow-up >=12 months

Restoration failure · Children (3-10 years) with dentine caries in primary molars · 1-5 years

Restoration failure · Children with carious primary teeth · 1 year, ART; Class I

Secondary caries · Patients with permanent dentition in need of restorations · 18 months to 2 years, All types of cavities

Caries prevalence · European adolescents aged 12–19 years · Examination year: < 2010

Early childhood caries (ECC) - association at lead SNP rs76823412 (8:134690570; nearest gene(s) ST3GAL1) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5… · Cross-sectional (ECC ascertained at the last dental exam before age 6), rs76823412 (8:134690570); effect/non-effect allele T/C; MAF 0.47; direction across 5 cohorts +++++

Contribution of dental care products to total daily fluoride intake (TDFI), by tap-water fluoride level · Children using fluoride-containing dental care products (majority of included studies) · Habitual daily intake, Extreme-fluoridated tap water (>1.5 mg/L)

Caries prevalence · European adolescents aged 19 years · Exact age

Specificity for detecting enamel caries · Asymptomatic children or adults suspected of enamel caries (clinical studies); extracted teeth (in vitro studies) · Analysis 2: network meta-analysis (all studies evaluating >=2 index tests)

Color change · Patients with post-orthodontic white spot lesions and permanent dentition · 6 months

Caries (DMFT/DMFS) in mixed/permanent dentition · School children and adolescents (6-18 years) followed from primary dentition (baseline examination before 72 months of…

Caries experience in the primary dentition (dmft/dmfs/dfs/deft/ds; pooled as standardized mean difference) · Children in the primary dentition with non-syndromic cleft lip and/or palate (CL/P) and comparable children without CL/P · Overall (all dentition groups)

Difference in summary specificity (NMA, Analysis 2) · Electrical conductance vs Visual

Difference in summary sensitivity (NMA, Analysis 2) · Electrical conductance vs Transillumination

Caries prevalence · 12-year-old children (permanent dentition) in Africa · Country: Tanzania

Caries arrest · Children with dentine carious lesions (ICDAS 4-5) in primary teeth · 24 months, Biannual vs annual application

Immediate bond strength (MPa) · Dental adhesives bonded to caries-affected dentin (in vitro) · Immediate bond strength, Caries-affected dentin (without rinsing step)

Contribution of dental care products to total fluoride exposure · Pregnant and lactating women

Dental caries measured by net increment in DMFS scores · Primary school children (aged 3-16 years) attending primary school in low- and middle-income countries (LMICs) · Post-intervention; follow-up varied across studies (interventions ranged from <2 years to >=2 years and longer)

Caries prevalence · 12-year-old children (permanent dentition) in Africa · Country: Algeria

Contribution of dental care products to total daily fluoride intake (TDFI), by tap-water fluoride level · Children using fluoride-containing dental care products (majority of included studies) · Habitual daily intake, Poor-fluoridated tap water (<0.3 mg/L)

Middle SES prevalence (among children with caries) · Children with dental caries (deciduous and/or permanent dentition) in low- and middle-income countries · Middle SES

Oral candidiasis prevalence · Children and adolescents (<18 years) living with HIV (CLWH)

Crown retention · Children with primary (deciduous) teeth requiring full-coverage crown restoration · 12 months

High SES prevalence (among children with caries) · Children with dental caries (deciduous and/or permanent dentition) in low- and middle-income countries · High SES

Food preference · Children and adolescents aged 0-19 years · Crossover designs with binary outcomes

Caries development in permanent teeth · School children and adolescents (6-18 years) followed from primary dentition (baseline examination before 72 months of…

Linear gingival erythema (WHO clinical stage 2) · Children and adolescents (<18 years) · Cross-sectional (case-control; single time point)

Caries prevalence · 12-year-old children (permanent dentition) in Africa · Country: Zambia