Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

611 questions · 621 findings · 112 reviews

No studies found 53 · 8.5%GRADE not reported 70 · 11.3%Very low 91 · 14.7%Low 216 · 34.8%Moderate 152 · 24.5%High 39 · 6.3%

Community and primary care based maternal oral health interventions vs Usual antenatal care or no structured oral health intervention

Preterm birth (<37 weeks) · Pregnant women and postpartum mothers

Maternal oral health interventions may reduce preterm birth, but the pooled RCT estimate was not statistically significant (low certainty).

1 finding from 1 review

Summary of findings table ‐ Midwife continuity models vs other models of care

Preterm birth · childbearing women and their infants (all) (important/secondary outcomes)

Summary of findings table ‐ Midwife continuity of care models showed no clear difference in preterm birth (< 37 weeks) compared with other models of care (low certainty).

1 finding from 1 review

Summary of findings table ‐ Vitamin B12 supplementation vs no supplementation or placebo

Preterm birth · pregnant women

Summary of findings table ‐ Vitamin B12 supplementation showed no clear difference in preterm birth (< 37 weeks) compared with placebo/no vitamin B12 supplementation (low certainty).

1 finding from 1 review

Setting of BP measurement: self‐measurement vs conventional clinic measurement

Preterm birth less than 34 weeks' gestation · pregnant women with chronic or gestational hypertension

Setting of BP measurement: self‐measurement showed no clear difference in preterm birth (birth before 34 completed weeks' gestation) compared with conventional clinic measurement (low certainty).

1 finding from 1 review

GM‐CSF‐supplemented culture media vs culture media not supplemented with GM‐CSF

Preterm birth · women undergoing assisted reproduction

It is very uncertain whether GM‐CSF‐supplemented culture media changes preterm birth compared with culture media not supplemented with GM‐CSF (very low certainty).

1 finding from 1 review

Intervention not reported

Preterm birth (before 37 weeks' gestation) · pregnant women considered to be at risk of developing pre‐eclampsia

The intervention leads to lower preterm birth (before 37 weeks' gestation) (high certainty).

1 finding from 1 review

Intervention not reported

Pregnancy with serious adverse outcome (composite including maternal death, baby death, pre‐eclampsia, small‐for‐gestational age, preterm birth) ‐ only trials with individual participant data · pregnant women considered to be at risk of developing pre‐eclampsia

The intervention leads to lower pregnancy with serious adverse outcome (composite including maternal… (high certainty).

1 finding from 1 review

Vitamin D + calcium + other vitamins and minerals vs calcium + other vitamins and minerals (but no vitamin D)

Preterm birth · pregnant women and their infants..

Vitamin D + calcium + other vitamins and minerals showed no clear difference in preterm birth (less than 37 weeks' gestation) compared with calcium + other vitamins and minerals (but no vitamin D) (low certainty).

1 finding from 1 review