Cochrane · systematic review · CD015134
Respiratory syncytial virus vaccination during pregnancy for improving infant outcomes
Phijffer, EWEM, de Bruin, O, Ahmadizar, F, et al. · Cochrane Database of Systematic Reviews · 2024 · Cochrane Library
Pregnancy and ChildbirthAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
8
current version
GRADE rated
7
No studies
1
Included studies
NR
No studies 1 · 12.5%Ungraded 0 · 0%Very low 2 · 25%Low 2 · 25%Moderate 1 · 12.5%High 2 · 25%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Respiratory syncytial virus vaccine compared to placebo in pregnant woman
Population: pregnant woman
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Infant hospitalisation with laboratory‐confirmed RSV disease Respiratory syncytial virus vaccine vs placebo | RR 0.5 [0.31, 0.82] | 4 studies · 12216 participants | High |
Infant hospitalisation with clinically confirmed RSV disease Respiratory syncytial virus vaccine vs placebo | no estimate extracted | NR | No studies |
Intrauterine growth restriction Respiratory syncytial virus vaccine vs placebo | RR 1.32 [0.75, 2.33] | 4 studies · 12545 participants | Moderate Downgraded: imprecision |
Stillbirth Respiratory syncytial virus vaccine vs placebo | RR 0.81 [0.38, 1.72] | 5 studies · 12652 participants | Low Downgraded: risk of bias, imprecision |
Maternal death Respiratory syncytial virus vaccine vs placebo | RR 3 [0.12, 73.5] | 3 studies · 7977 participants | Low Downgraded: imprecision |
Preterm birth Respiratory syncytial virus vaccine vs placebo | RR 1.16 [0.99, 1.36] | 6 studies · 17560 participants | Very low Downgraded: risk of bias, imprecision |
Congenital abnormalities Respiratory syncytial virus vaccine vs placebo | RR 0.96 [0.88, 1.04] | 4 studies · 12304 participants | High |
Infant death Respiratory syncytial virus vaccine vs placebo | RR 0.81 [0.36, 1.81] | 6 studies · 17589 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |