Cochrane · systematic review · CD013823
Vitamin B12 supplementation during pregnancy for maternal and child health outcomes
Finkelstein, JL, Fothergill, A, Venkatramanan, S, et al. · Cochrane Database of Systematic Reviews · 2024 · Cochrane Library
Pregnancy and ChildbirthAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
6
No studies
1
Included studies
NR
No studies 1 · 14.3%Ungraded 0 · 0%Very low 3 · 42.9%Low 3 · 42.9%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Summary of findings table ‐ Vitamin B12 supplementation compared to placebo/no vitamin B12 supplementation in pregnant women
Population: pregnant women
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Maternal anaemia Summary of findings table ‐ Vitamin B12 supplementation vs placebo/no vitamin B12 supplementation | RR 1.08 [0.93, 1.26] | 2 studies · 284 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Maternal vitamin B12 deficiency Summary of findings table ‐ Vitamin B12 supplementation vs placebo/no vitamin B12 supplementation | RR 0.38 [0.28, 0.51] | 2 studies · 272 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Spontaneous abortion or miscarriage Summary of findings table ‐ Vitamin B12 supplementation vs placebo/no vitamin B12 supplementation | no estimate extracted | 2 studies · 448 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Low birthweight (< 2500 g) Summary of findings table ‐ Vitamin B12 supplementation vs placebo/no vitamin B12 supplementation | RR 1.5 [0.93, 2.43] | 2 studies · 334 participants | Low Downgraded: risk of bias, imprecision |
Preterm birth (< 37 weeks) Summary of findings table ‐ Vitamin B12 supplementation vs placebo/no vitamin B12 supplementation | RR 0.97 [0.55, 1.74] | 2 studies · 340 participants | Low Downgraded: risk of bias, imprecision |
Child cognitive outcomes Summary of findings table ‐ Vitamin B12 supplementation vs placebo/no vitamin B12 supplementation | no estimate extracted | 1 study · 178 participants | Low Downgraded: imprecision, inconsistency |
Neural tube defects ‐ not reported Summary of findings table ‐ Vitamin B12 supplementation vs placebo/no vitamin B12 supplementation | no estimate extracted | NR | No studies |