Cochrane · systematic review · CD013446
Regimens of vitamin D supplementation for women during pregnancy
Palacios, C, Trak‐Fellermeier, MA, Martinez, RX, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
Pregnancy and ChildbirthAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
8
current version
GRADE rated
8
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 12.5%Low 6 · 75%Moderate 1 · 12.5%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
A dose of vitamin D 601 IU or higher compared to 600 IU or lower alone or with other nutrients for women during pregnancy
Population: women during pregnancy.
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Pre‐eclampsia A dose of vitamin D 601 IU or higher vs 600 IU or lower alone or with other nutrients | RR 0.96 [0.65, 1.42] | 5 studies · 1553 participants | Low Downgraded: risk of bias, imprecision |
Gestational diabetes A dose of vitamin D 601 IU or higher vs 600 IU or lower alone or with other nutrients | RR 0.54 [0.34, 0.86] | 5 studies · 1846 participants | Moderate Downgraded: risk of bias, imprecision |
Preterm birth A dose of vitamin D 601 IU or higher vs 600 IU or lower alone or with other nutrients | RR 1.25 [0.92, 1.69] | 4 studies · 2294 participants | Low Downgraded: risk of bias, imprecision |
Low birthweight A dose of vitamin D 601 IU or higher vs 600 IU or lower alone or with other nutrients | RR 0.9 [0.66, 1.24] | 4 studies · 1550 participants | Very low Downgraded: risk of bias, imprecision |
A dose of vitamin D 4000 IU/d or more compared to 3999 IU/d or less alone or with any other nutrient for women during pregnancy
Population: women during pregnancy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Pre‐eclampsia A dose of vitamin D 4000 IU/d or more vs 3999 IU/d or less alone or with any other nutrient | RR 0.87 [0.62, 1.22] | 4 studies · 1903 participants | Low Downgraded: risk of bias, imprecision |
Gestational diabetes A dose of vitamin D 4000 IU/d or more vs 3999 IU/d or less alone or with any other nutrient | RR 0.89 [0.56, 1.42] | 5 studies · 2276 participants | Low Downgraded: risk of bias, imprecision |
Preterm birth A dose of vitamin D 4000 IU/d or more vs 3999 IU/d or less alone or with any other nutrient | RR 0.85 [0.64, 1.12] | 6 studies · 2948 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Low birthweight A dose of vitamin D 4000 IU/d or more vs 3999 IU/d or less alone or with any other nutrient | RR 0.92 [0.49, 1.7] | 2 studies · 1099 participants | Low Downgraded: risk of bias, imprecision, indirectness |