Cochrane · systematic review · CD013497
GM‐CSF (granulocyte macrophage colony‐stimulating factor) supplementation in culture media for women undergoing assisted reproduction
Armstrong, S, MacKenzie, J, Woodward, B, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
Gynaecology and FertilityAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
8
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 1 · 12.5%Very low 2 · 25%Low 5 · 62.5%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
GM‐CSF‐supplemented culture media compared to culture media not supplemented with GM‐CSF for women undergoing assisted reproduction
Population: women undergoing assisted reproduction
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth or ongoing pregnancy GM‐CSF‐supplemented culture media vs culture media not supplemented with GM‐CSF | OR 1.19 [0.93, 1.52] | 2 studies · 1432 participants | Low Downgraded: imprecision, inconsistency |
Miscarriage GM‐CSF‐supplemented culture media vs culture media not supplemented with GM‐CSF | OR 0.75 [0.41, 1.36] | 2 studies · 1432 participants | Low Downgraded: imprecision |
Clinical pregnancy GM‐CSF‐supplemented culture media vs culture media not supplemented with GM‐CSF | OR 1.16 [0.93, 1.45] | 3 studies · 1532 participants | Low Downgraded: risk of bias, inconsistency |
Multiple gestation GM‐CSF‐supplemented culture media vs culture media not supplemented with GM‐CSF | OR 1.24 [0.73, 2.1] | 2 studies · 1432 participants | Very low Downgraded: imprecision, inconsistency |
Preterm birth GM‐CSF‐supplemented culture media vs culture media not supplemented with GM‐CSF | OR 1.2 [0.7, 2.04] | 2 studies · 1432 participants | Very low Downgraded: imprecision, inconsistency |
Birth defects GM‐CSF‐supplemented culture media vs culture media not supplemented with GM‐CSF | OR 1.33 [0.59, 3.01] | 2 studies · 1432 participants | Low Downgraded: imprecision |
Aneuploidy GM‐CSF‐supplemented culture media vs culture media not supplemented with GM‐CSF | OR 0.34 [0.03, 3.26] | 2 studies · 1432 participants | Low Downgraded: imprecision |
Stillbirth GM‐CSF‐supplemented culture media vs culture media not supplemented with GM‐CSF | no estimate extracted | 2 studies · 1432 participants | Ungraded |