Search review questions

Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Hänsel Petersson,2010 [31]; model performance 2

Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Gao,2013 [29]; model performance 9

Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Gao,2013 [29]; model performance 7

Adverse events associated with treatment · Adults with oral cavity or oropharyngeal cancer

MMP-2 expression/activity · Human ex vivo carious dentin under sealed cavities · Before vs after sealing (Kuhn 2016: 60 days follow-up)

Oral health-related quality of life (OHRQoL), impaired (qualitative synthesis) · Adolescents aged 10-19 years

Secondary caries (occurrence) · Patients requiring dental restoration; deciduous (primary) teeth · 2 or more years of follow-up

MMP-20 expression/activity · Human ex vivo carious dentin (head/neck radiotherapy)

Locoregional recurrence · Adults with oral cavity or oropharyngeal cancer with nodal disease (stage N2 or N3) · 3 years

Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Birpou,2019 [25]; model performance 10

Locoregional recurrence · Adults with oral cavity cancer (tongue or floor of mouth) and clinically negative neck nodes · 3 years

New active carious lesions (permanent first molars) · Llodra 2005 (6-monthly SDF, Cuba)

Plaque-related index · Orthodontic patients · ≤ 3 months

Pulp necrosis · Compound impression material

Total mortality · Adults with oral cavity or oropharyngeal cancer

Periapical pathosis · Vital teeth restored with indirect restorations · ≤5 years, Follow-up ≤5 years

Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Birpou,2019 [25]; model performance 6

Secondary caries (occurrence) · Patients requiring dental restoration; deciduous (primary) teeth · 2 or more years of follow-up

Shear bond strength (SBS) of metallic orthodontic brackets · Extracted permanent human teeth (enamel); sound or demineralized · Before bonding

Recurrence · Adults with oral cavity cancer · 5 years

Pulp necrosis · Vital teeth restored with indirect restorations · Follow-up ≤5 to >10 years, Treated by undergraduate students

Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Birpou,2019 [25]; model performance 9

Adverse events (participants with >=1 adverse event) · Adults with Parkinson's disease and sialorrhea (drooling) · Approximately 1 month post-injection (one study ~1 week), BoNT type B

Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Pang,2021 [19]; model performance 1

Unstimulated whole salivary flow rate · Elderly (>60 years) and medically compromised adults with xerostomia / dry mouth · Gum chewed daily for >=2 weeks (2 to 12 weeks; multiple time points for Kim and Ozen)

Oral health-related quality of life (dichotomous: poor vs not) · Indian adults and elderly (police, teachers, general and institutionalised populations)

Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Birpou,2019 [25]; model performance 8

Recurrence · Adults with oral cavity or oropharyngeal cancer

Root caries increment · Individuals of all ages · Follow-up ≥1 year, Hayes,2017 [33]; model performance 5

Secondary caries (occurrence) · Patients requiring dental restoration; permanent teeth · 2 or more years of follow-up

New coronal carious lesions or fillings on permanent (first) molars (caries prevention) · Children with dental caries in permanent (first) molars · 12 months, Mauro 2004 (permanent first molars, one-time SDF; Argentina)

Oral health-related quality of life (dichotomous: poor vs not) · Indians across all ages (children, adolescents, adults, elderly)

Periapical pathosis · Vital teeth restored with indirect restorations · Follow-up ≤5 to >10 years, Single-unit restorations

Dental caries · Children (<19 years) · Adjusted for confounders

Oral health-related quality of life (continuous), measured by OHIP-14 · Indian elderly and general-population adults

Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Pang,2021 [19]; model performance 3

new root-surface carious lesions or restorations · community-dwelling older adults with root caries · 24 months

Clinical and radiographic success (composite) · Patients with carious pulp exposure in permanent teeth undergoing DPC or pulpotomy · ≥6 months follow-up

Caries arrest rate in permanent posterior teeth · Mendiratta 2021 (intellectually disabled, India)

Pulp necrosis · Vital teeth restored with indirect restorations · Follow-up ≤5 to >10 years, Glass ionomer (GIC) permanent cement

Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Gao,2013 [29]; model performance 6

Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic…

Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Pang,2021 [19]; model performance 4

Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Hänsel Petersson,2002 [18]; model performance 1

Pulp necrosis incidence · Vital teeth · Cheung et al. 2005 maxillary posterior

Risk of malnutrition (younger children, 6 months to 6 years) · Children in early childhood (0-6 years) · Zahid et al. 2020 (Nepal; children 6 months-6 years)

Clinical and radiographic success · Patients with carious pulp exposure in mature permanent teeth · 1 to 3 years, Mature teeth

Oral health-related quality of life (continuous), measured by OHIP-14 / ECOHIS / Michigan Oral Health QoL · Indians across all ages (children, adolescents, adults, elderly)

Root caries increment · Individuals of all ages · Follow-up ≥1 year, Ritter,2016 [22]; model performance 1

Cathepsin B presence/activity · Human coronal carious dentin and sound dentin