Early childhood caries (ECC) · Children aged ≤6 years (early childhood)
RETRACTED. Among studies before 2017, oral C. albicans presence was associated with higher odds of ECC (OR 4.89, 95% CI 2.79-8.58); ungraded subgroup from a retracted review.
16 findings from 1 review
Show 13 more findings
RETRACTED: Investigating the association between Candida albicans and early childhood dental caries: A comprehensive… 2024 All outcomesExposure and outcome assessed concurrently (observational); children aged ≤6 years · Children aged ≤6 years; multiple countries (Asia, Europe, Americas); dental/clinical and community settings · Study quality (NOS): good
OR 5.32 [2.89, 9.80]
7 studies
GRADE not reported
RETRACTED: Investigating the association between Candida albicans and early childhood dental caries: A comprehensive… 2024 All outcomesExposure and outcome assessed concurrently (observational); children aged ≤6 years · Children aged ≤6 years; multiple countries (Asia, Europe, Americas); dental/clinical and community settings · Sample collection: saliva
OR 4.70 [2.44, 9.09]
7 studies
GRADE not reported
RETRACTED: Investigating the association between Candida albicans and early childhood dental caries: A comprehensive… 2024 All outcomesExposure and outcome assessed concurrently (observational); children aged ≤6 years · Children aged ≤6 years; multiple countries (Asia, Europe, Americas); dental/clinical and community settings · Overall (all 22 studies, random-effects)
OR 4.42 [3.14, 6.24]
22 studies · 3301 participants
GRADE not reported
RETRACTED: Investigating the association between Candida albicans and early childhood dental caries: A comprehensive… 2024 All outcomesExposure and outcome assessed concurrently (observational); children aged ≤6 years · Children aged ≤6 years; multiple countries (Asia, Europe, Americas); dental/clinical and community settings · Sample size: >=100 (Table 6; abstract text erroneously states '>=1000')
OR 4.65 [2.57, 8.42]
6 studies
GRADE not reported
RETRACTED: Investigating the association between Candida albicans and early childhood dental caries: A comprehensive… 2024 All outcomesExposure and outcome assessed concurrently (observational); children aged ≤6 years · Children aged ≤6 years; multiple countries (Asia, Europe, Americas); dental/clinical and community settings · Sample collection: oral swab
OR 9.55 [2.17, 42.01]
2 studies
GRADE not reported
RETRACTED: Investigating the association between Candida albicans and early childhood dental caries: A comprehensive… 2024 All outcomesExposure and outcome assessed concurrently (observational); children aged ≤6 years · Children aged ≤6 years; multiple countries (Asia, Europe, Americas); dental/clinical and community settings · Study design: case-control
OR 5.30 [1.72, 16.31]
2 studies · 708 participants
GRADE not reported
RETRACTED: Investigating the association between Candida albicans and early childhood dental caries: A comprehensive… 2024 All outcomesExposure and outcome assessed concurrently (observational); children aged ≤6 years · Children aged ≤6 years; multiple countries (Asia, Europe, Americas); dental/clinical and community settings · Region: Asia
OR 3.62 [2.53, 5.20]
12 studies · 2347 participants
GRADE not reported
RETRACTED: Investigating the association between Candida albicans and early childhood dental caries: A comprehensive… 2024 All outcomesExposure and outcome assessed concurrently (observational); children aged ≤6 years · Children aged ≤6 years; multiple countries (Asia, Europe, Americas); dental/clinical and community settings · Sample size: <100 (Table 6; abstract text erroneously states '<1000')
OR 4.35 [2.75, 6.89]
16 studies
GRADE not reported
RETRACTED: Investigating the association between Candida albicans and early childhood dental caries: A comprehensive… 2024 All outcomesExposure and outcome assessed concurrently (observational); children aged ≤6 years · Children aged ≤6 years; multiple countries (Asia, Europe, Americas); dental/clinical and community settings · Time period: 2018 and later
OR 4.17 [2.62, 6.64]
12 studies
GRADE not reported
RETRACTED: Investigating the association between Candida albicans and early childhood dental caries: A comprehensive… 2024 All outcomesExposure and outcome assessed concurrently (observational); children aged ≤6 years · Children aged ≤6 years; multiple countries (Asia, Europe, Americas); dental/clinical and community settings · Study design: cross-sectional
OR 4.30 [2.92, 6.33]
20 studies · 2593 participants
GRADE not reported
RETRACTED: Investigating the association between Candida albicans and early childhood dental caries: A comprehensive… 2024 All outcomesExposure and outcome assessed concurrently (observational); children aged ≤6 years · Children aged ≤6 years; multiple countries (Asia, Europe, Americas); dental/clinical and community settings · Study quality (NOS): moderate
OR 3.84 [2.24, 6.57]
11 studies
GRADE not reported
RETRACTED: Investigating the association between Candida albicans and early childhood dental caries: A comprehensive… 2024 All outcomesExposure and outcome assessed concurrently (observational); children aged ≤6 years · Children aged ≤6 years; multiple countries (Asia, Europe, Americas); dental/clinical and community settings · Region: America/Canada/Brazil/Chile
OR 3.98 [1.14, 13.87]
5 studies · 319 participants
GRADE not reported
RETRACTED: Investigating the association between Candida albicans and early childhood dental caries: A comprehensive… 2024 All outcomesExposure and outcome assessed concurrently (observational); children aged ≤6 years · Children aged ≤6 years; multiple countries (Asia, Europe, Americas); dental/clinical and community settings · Study quality (NOS): low
OR 5.14 [2.12, 12.48]
4 studies
GRADE not reported
new root-surface carious lesions or restorations · community-dwelling older adults with root caries
SDF plus oral health education had a 33% preventative fraction at 24 months; no pooled estimate or GRADE rating was reported.
1 finding from 1 review
new root-surface carious lesions or restorations · community-dwelling older adults with root caries
SDF had a 62% preventative fraction; no pooled estimate or GRADE rating was reported.
1 finding from 1 review
Arrest or reversal of noncavitated facial/lingual carious lesions · Children and adults with noncavitated carious lesions on facial/lingual surfaces (primary and permanent teeth)
1.23% APF gel + oral health education was probably more effective than Oral health education for arrest or reversal of facial/lingual carious lesions (RR 2.47, 95% CI 1.95 to 3.13; moderate certainty).
1 finding from 1 review
new root-surface carious lesions or restorations · Older adults with root caries in permanent (mature) teeth (mean age 75 years)
SDF had a 71% preventative fraction at 36 months; no pooled estimate or GRADE rating was reported.
1 finding from 1 review
Development of any (cavitated or non-cavitated) carious lesion · Children younger than 6 years with caries-free primary dentition (no cavitated or non-cavitated lesions at baseline)
Preschool children with mutans streptococci at baseline probably have about four times higher odds of developing early childhood caries (OR 4.13; moderate certainty).
10 findings from 1 review
Is Mutans Streptococci count a risk predictor of Early Childhood Caries? A systematic review and meta-analysis. 2023 All outcomes6 months to 3.5 years · Caries-free preschool children (<6 y), primary dentition; community/clinic; studies from Japan, Finland, USA, Sweden and Singapore · Overall
OR 4.13 [3.33, 5.12]
12 studies · 3010 participants
Moderate
Is Mutans Streptococci count a risk predictor of Early Childhood Caries? A systematic review and meta-analysis. 2023 All outcomes6 months to 3.5 years · Caries-free preschool children (<6 y), primary dentition; community/clinic; studies from Japan, Finland, USA, Sweden and Singapore · Sample: plaque
OR 5.16 [2.99, 8.91]
5 studies · 736 participants
GRADE not reported
Is Mutans Streptococci count a risk predictor of Early Childhood Caries? A systematic review and meta-analysis. 2023 All outcomes6 months to 3.5 years · Caries-free preschool children (<6 y), primary dentition; community/clinic; studies from Japan, Finland, USA, Sweden and Singapore · Sample: saliva
OR 3.92 [3.20, 4.80]
9 studies · 2577 participants
GRADE not reported
Show 7 more findings
Is Mutans Streptococci count a risk predictor of Early Childhood Caries? A systematic review and meta-analysis. 2023 All outcomes1 year · Caries-free preschool children (<6 y), primary dentition; community/clinic; studies from Japan, Finland, USA, Sweden and Singapore · Follow-up: 1 year
OR 4.37 [3.50, 5.45]
4 studies · 2016 participants
GRADE not reported
Is Mutans Streptococci count a risk predictor of Early Childhood Caries? A systematic review and meta-analysis. 2023 All outcomes2.7 years (31 months median) · Caries-free preschool children (<6 y), primary dentition; community/clinic; studies from Japan, Finland, USA, Sweden and Singapore · Follow-up: 2.7 years (31 months median)
OR 33.00 [3.18, 342.26]
1 study · 28 participants
GRADE not reported
Is Mutans Streptococci count a risk predictor of Early Childhood Caries? A systematic review and meta-analysis. 2023 All outcomes2 years · Caries-free preschool children (<6 y), primary dentition; community/clinic; studies from Japan, Finland, USA, Sweden and Singapore · Follow-up: 2 years
OR 2.53 [1.22, 5.23]
4 studies · 297 participants
GRADE not reported
Is Mutans Streptococci count a risk predictor of Early Childhood Caries? A systematic review and meta-analysis. 2023 All outcomes6 months to 3.5 years · Caries-free preschool children (<6 y), primary dentition; community/clinic; studies from Japan, Finland, USA, Sweden and Singapore · Microbiological assessment: quantitative (culture/CFU counting)
OR 3.82 [2.01, 7.26]
6 studies · 732 participants
GRADE not reported
Is Mutans Streptococci count a risk predictor of Early Childhood Caries? A systematic review and meta-analysis. 2023 All outcomes3.5 years (42 months) · Caries-free preschool children (<6 y), primary dentition; community/clinic; studies from Japan, Finland, USA, Sweden and Singapore · Follow-up: 3.5 years (42 months)
OR 4.23 [2.49, 7.18]
1 study · 366 participants
GRADE not reported
Is Mutans Streptococci count a risk predictor of Early Childhood Caries? A systematic review and meta-analysis. 2023 All outcomes6 months · Caries-free preschool children (<6 y), primary dentition; community/clinic; studies from Japan, Finland, USA, Sweden and Singapore · Follow-up: 6 months
OR 4.65 [2.01, 10.76]
2 studies · 303 participants
GRADE not reported
Is Mutans Streptococci count a risk predictor of Early Childhood Caries? A systematic review and meta-analysis. 2023 All outcomes6 months to 3.5 years · Caries-free preschool children (<6 y), primary dentition; community/clinic; studies from Japan, Finland, USA, Sweden and Singapore · Microbiological assessment: semi-quantitative (Dentocult/commercial kit)
OR 4.36 [3.53, 5.39]
6 studies · 2278 participants
GRADE not reported
Future caries experience (dmft/dmfs) · Children younger than 6 years with caries-free primary dentition (no cavitated or non-cavitated lesions at baseline)
Children with mutans streptococci at baseline had a greater future caries experience (SMD 0.85, a large effect; ungraded).
1 finding from 1 review
new root-surface carious lesions or restorations · community-dwelling older adults with root caries
SDF plus potassium iodide had a 52% preventative fraction; no pooled estimate or GRADE rating was reported.
1 finding from 1 review
Caries development in permanent teeth · School children and adolescents (6-18 years) followed from primary dentition (baseline examination before 72 months of age)
Early-childhood oral hygiene and dietary habits show inconsistent associations with permanent-teeth caries, often losing significance after adjustment for past caries (2 studies; not pooled; not GRADE-rated).
1 finding from 1 review
Cariogenic and commensal oral bacteria (S. mutans and commensal streptococci growth, adhesion, biofilm) · Oral bacteria (streptococci), dental hard tissue (enamel/dentin) and e-liquids studied in vitro/ex vivo (with a few clinical microbiome…
Most in vitro studies indicate e-cigarette aerosol/e-liquid (especially flavored/high-concentration) disrupts normal oral flora and favors cariogenic S. mutans growth and biofilm, plausibly increasing caries risk; not pooled (ungraded, narrative).
1 finding from 1 review
Caries (DMFT) and enamel defects · Preterm children (about 8 years old) in the United Arab Emirates (Dubai)
One study found preterm children had higher DMFT and a fourfold higher prevalence of enamel defects than full-term children (narrative synthesis; not GRADE-rated).
1 finding from 1 review
Alshehhi et al. (Dubai) reported a significantly higher mean DMFT (1.00 vs 0.38) and a 4-times higher prevalence of enamel defects (58.15% vs 24.2%; OR 4.33, 95% CI 2.01-9.36) in preterm vs full-term children, highest…
1 study
GRADE not reported
Dental caries estimates · People receiving or providing primary care; all ages, ability types, and locations
Seven studies measured change in dental caries estimates.
1 finding from 1 review
Baby bottle tooth decay prevalence · Alaska Native and American Indian Head Start children
High-intensity community education was associated with a 33% reduction in BBTD prevalence, without a GRADE rating.
3 findings from 1 review
Percent reduction in BBTD prevalence 33
1 study
GRADE not reported
Percent reduction in BBTD prevalence 18
1 study
GRADE not reported
Percent reduction in BBTD prevalence 27
1 study
GRADE not reported
Baby bottle tooth decay prevalence · Alaska Native Head Start children
The Alaska Native site had a 20% increase in BBTD prevalence, without a GRADE rating.
1 finding from 1 review
Inter-examiner reliability · Children and adults with primary or permanent dentition
Inter-examiner kappa statistics ranged from 0.44 to 0.91 across 13 studies; no meta-analysis or GRADE rating was reported.
1 finding from 1 review
no estimate extracted
13 studies
GRADE not reported
Positive predictive value for dental caries diagnosis · Children and adults with primary or permanent dentition
Positive predictive values were reported in 10 of the 13 studies that reported sensitivity and specificity; no meta-analysis or GRADE rating was reported.
1 finding from 1 review
no estimate extracted
10 studies
GRADE not reported
Negative predictive value for dental caries diagnosis · Children and adults with primary or permanent dentition
Negative predictive values were reported in 10 of the 13 studies that reported sensitivity and specificity; no meta-analysis or GRADE rating was reported.
1 finding from 1 review
no estimate extracted
10 studies
GRADE not reported
Intra-examiner reliability · Children and adults with primary or permanent dentition
Intra-examiner kappa statistics ranged from 0.52 to 1.00 across 6 studies; no meta-analysis or GRADE rating was reported.
1 finding from 1 review
no estimate extracted
6 studies
GRADE not reported
Sensitivity for dental caries diagnosis · Children and adults with primary or permanent dentition
Sensitivity ranged from 48% to 98.3% across 13 studies; no meta-analysis or GRADE rating was reported.
1 finding from 1 review
d/D dft/DFT or dmft/DMFT score differences · Children and adults with primary or permanent dentition
Eight studies calculated caries-score differences; six reported no significant difference, one underestimation, and one overestimation with teledentistry.
1 finding from 1 review
no estimate extracted
8 studies
GRADE not reported