Search review questions

Adverse events Any untoward medical occurrence regarding medications · people with neurosyphilis

Recurrence of neurosyphilis · people with neurosyphilis

Time to recovery · people with neurosyphilis

Quality of life · people with neurosyphilis

Withdrawals · people with neurosyphilis

Neonatal death rate due congenital syphilis · newborns with congenital syphilis

Serological cure (4‐fold decrease or greater in non‐treponemal tests titre) · newborns with congenital syphilis

Minor adverse events of therapy · newborns with congenital syphilis

Neonatal death rate due any cause · newborns with congenital syphilis

Absence of clinical manifestations of congenital syphilis during · newborns with congenital syphilis

Serious adverse events · newborns with congenital syphilis

Serological cure (≥ 4‐fold decrease in non‐treponemal tests titre) · newborns with congenital syphilis

Minor adverse events of therapy · newborns with congenital syphilis

Neonatal death rate due congenital syphilis · newborns with congenital syphilis

Neonatal death rate due to any cause · newborns with congenital syphilis

Absence of clinical manifestations of congenital syphilis during · newborns with congenital syphilis

Clinical cure rate (short‐term) · non‐pregnant women with vulvovaginal candidiasis

Clinical cure rate (long‐term) · non‐pregnant women with vulvovaginal candidiasis

Mycological cure rate (short‐term) · non‐pregnant women with vulvovaginal candidiasis

Mycological cure rate (long‐term) · non‐pregnant women with vulvovaginal candidiasis

Relapse rate · non‐pregnant women with vulvovaginal candidiasis

Rate of serious adverse events · non‐pregnant women with vulvovaginal candidiasis

Clinical cure: syndromic approach · sexually active adults

Clinical cure: aetiological approach · sexually active adults

Clinical improvement: syndromic approach · sexually active adults

Clinical improvement: aetiological approach · sexually active adults

Microbiological cure · sexually active adults

Minor adverse events · sexually active adults

Clinical cure: syndromic approach · sexually active adults

Clinical cure: aetiological approach · sexually active adults

Minor adverse events · sexually active adults

Duration of symptoms from onset of treatment · men and women with their first episode of genital herpes

Adverse events · men and women with their first episode of genital herpes

Duration of lesions from onset of treatment · men and women with their first episode of genital herpes

Time to recurrence · men and women with their first episode of genital herpes

Duration of symptoms from onset of treatment · men and women with their first episode of genital herpes

Duration of lesions from onset of treatment · men and women with their first episode of genital herpes

Adverse events ‐ pain with topical application · men and women with their first episode of genital herpes

Time to recurrence · men and women with their first episode of genital herpes

Chlamydia prevalence (general population) Outcome was chlamydia test positivity after 3 yearly invitations in intervention clusters vs 1 invitation in control areas. Uptake was too low for chlamydia positivity to be considered an unbiased estimate... · healthy adults

Chlamydia prevalence (high risk population) Outcome was prevalence of positive chlamydia tests in repeated cross‐sectional surveys of women tested at sex venues after 4 years of intervention. · healthy adults

Incidence of pelvic inflammatory disease (PID) at 12 months (intention‐to‐treat) Outcome was clinically diagnosed PID reported by the participant or extracted from medical records, pharmacy records or hospital discharge coding. Outcome very likely... · healthy adults

Incidence of epididymitis in men at 12 months (intention‐to‐treat) Outcome was epididymitis diagnosed in hospital and abstracted from hospital discharge coding. · healthy adults

Recurrence · sexual partners of women with bacterial vaginosis

Symptomatic improvement · sexual partners of women with bacterial vaginosis

Recurrence · sexual partners of women with bacterial vaginosis

Clinical improvement during the first week · sexual partners of women with bacterial vaginosis

Clinical improvement · sexual partners of women with bacterial vaginosis

Clinical improvement · sexual partners of women with bacterial vaginosis

Symptomatic improvement during the first week · sexual partners of women with bacterial vaginosis