Cochrane · systematic review · CD010684
Interventions for men and women with their first episode of genital herpes
Heslop, R, Roberts, H, Flower, D, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
Sexually Transmitted InfectionsAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
8
current version
GRADE rated
8
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 3 · 37.5%Low 5 · 62.5%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Oral acyclovir versus placebo for men and women with their first episode of genital herpes
Population: men and women with their first episode of genital herpes
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Duration of symptoms from onset of treatment Oral acyclovir vs placebo | no estimate extracted | 2 studies · 82 participants | Low Downgraded: risk of bias, imprecision |
Adverse events Oral acyclovir vs placebo | no estimate extracted | 2 studies · 130 participants | Very low Downgraded: risk of bias, imprecision |
Duration of lesions from onset of treatment Oral acyclovir vs placebo | no estimate extracted | 2 studies · 86 participants | Low Downgraded: risk of bias, imprecision |
Time to recurrence Oral acyclovir vs placebo | no estimate extracted | 2 studies · 198 participants | Very low Downgraded: imprecision |
Topical acyclovir versus placebo for men and women with their first episode of genital herpes
Population: men and women with their first episode of genital herpes
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Duration of symptoms from onset of treatment Topical acyclovir vs placebo | no estimate extracted | 3 studies · 195 participants | Low Downgraded: risk of bias, inconsistency |
Duration of lesions from onset of treatment Topical acyclovir vs placebo | no estimate extracted | 3 studies · 195 participants | Low Downgraded: risk of bias, inconsistency |
Adverse events ‐ pain with topical application Topical acyclovir vs placebo | RR 0.74 [0.46, 1.2] | 3 studies · 247 participants | Low Downgraded: risk of bias |
Time to recurrence Topical acyclovir vs placebo | no estimate extracted | 3 studies · 129 participants | Very low Downgraded: risk of bias |