Cochrane · systematic review · CD012492
Macrolides for treatment of Haemophilus ducreyi infection in sexually active adults
Romero, L, Huerfano, C, Grillo‐Ardila, CF · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
Sexually Transmitted InfectionsAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
9
current version
GRADE rated
9
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 3 · 33.3%Low 6 · 66.7%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Macrolides compared to any other antibiotic for treatment of Haemophilus ducreyi infection in sexually active adults
Population: sexually active adults
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Clinical cure: syndromic approach Macrolides vs any other antibiotic | RR 1.09 [0.97, 1.21] | 2 studies · 340 participants | Low Downgraded: risk of bias |
Clinical cure: aetiological approach Macrolides vs any other antibiotic | RR 1.06 [0.98, 1.15] | 5 studies · 348 participants | Low Downgraded: risk of bias |
Clinical improvement: syndromic approach Macrolides vs any other antibiotic | RR 0.89 [0.52, 1.52] | 2 studies · 340 participants | Very low Downgraded: risk of bias |
Clinical improvement: aetiological approach Macrolides vs any other antibiotic | RR 0.8 [0.42, 1.51] | 3 studies · 187 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Microbiological cure Macrolides vs any other antibiotic | RR 0.93 [0.74, 1.16] | 1 study · 45 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Minor adverse events Macrolides vs any other antibiotic | RR 1.34 [0.24, 7.51] | 3 studies · 412 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Macrolide (erythromycin) compared to any other macrolide for Haemophilus ducreyi infection in sexually active adults
Population: sexually active adults
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Clinical cure: syndromic approach Macrolide (erythromycin) vs any other macrolide | RR 1 [0.91, 1.1] | 2 studies · 269 participants | Low Downgraded: risk of bias |
Clinical cure: aetiological approach Macrolide (erythromycin) vs any other macrolide | RR 1.04 [0.93, 1.16] | 2 studies · 211 participants | Low Downgraded: risk of bias |
Minor adverse events Macrolide (erythromycin) vs any other macrolide | RR 1.14 [0.63, 2.06] | 1 study · 101 participants | Very low Downgraded: risk of bias, imprecision |