Cochrane · systematic review · CD011399
Antibiotic therapy for adults with neurosyphilis
Buitrago‐Garcia, D, Martí‐Carvajal, AJ, Jimenez, A, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
Sexually Transmitted InfectionsAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
4
No studies
3
Included studies
NR
No studies 3 · 42.9%Ungraded 0 · 0%Very low 4 · 57.1%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Ceftriaxone compared to penicillin G for neurosyphilis
Population: people with neurosyphilis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Serological cure assessed by decrease in the CSF VDRL titre Ceftriaxone vs penicillin G | no estimate extracted | 1 study · 36 participants | Very low Downgraded: risk of bias, imprecision |
Clinical cure assessed by RPR decrease Ceftriaxone vs penicillin G | no estimate extracted | 1 study · 36 participants | Very low Downgraded: risk of bias, imprecision |
Adverse events Any untoward medical occurrence regarding medications Ceftriaxone vs penicillin G | no estimate extracted | 1 study · 1 participants | Very low Downgraded: risk of bias, imprecision |
Recurrence of neurosyphilis Ceftriaxone vs penicillin G | no estimate extracted | NR | No studies |
Time to recovery Ceftriaxone vs penicillin G | no estimate extracted | NR | No studies |
Quality of life Ceftriaxone vs penicillin G | no estimate extracted | NR | No studies |
Withdrawals Ceftriaxone vs penicillin G | RR 2 [0.42, 9.48] | 1 study · 36 participants | Very low Downgraded: risk of bias, imprecision |