Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

563 questions · 568 findings · 104 reviews · Headline outcomes only

No studies found 53 · 9.3%GRADE not reported 26 · 4.6%Very low 85 · 15%Low 214 · 37.7%Moderate 151 · 26.6%High 39 · 6.9%

GM‐CSF‐supplemented culture media vs culture media not supplemented with GM‐CSF

Preterm birth · women undergoing assisted reproduction

It is very uncertain whether GM‐CSF‐supplemented culture media changes preterm birth compared with culture media not supplemented with GM‐CSF (very low certainty).

1 finding from 1 review

Intervention not reported

Preterm birth (before 37 weeks' gestation) · pregnant women considered to be at risk of developing pre‐eclampsia

The intervention leads to lower preterm birth (before 37 weeks' gestation) (high certainty).

1 finding from 1 review

Intervention not reported

Pregnancy with serious adverse outcome (composite including maternal death, baby death, pre‐eclampsia, small‐for‐gestational age, preterm birth) ‐ only trials with individual participant data · pregnant women considered to be at risk of developing pre‐eclampsia

The intervention leads to lower pregnancy with serious adverse outcome (composite including maternal… (high certainty).

1 finding from 1 review

Vitamin D + calcium + other vitamins and minerals vs calcium + other vitamins and minerals (but no vitamin D)

Preterm birth · pregnant women and their infants..

Vitamin D + calcium + other vitamins and minerals showed no clear difference in preterm birth (less than 37 weeks' gestation) compared with calcium + other vitamins and minerals (but no vitamin D) (low certainty).

1 finding from 1 review

Intervention not reported

Preterm birth < 37 weeks · pregnant women and their babies

The intervention leads to lower preterm birth < 37 weeks (high certainty).

1 finding from 1 review

Intervention not reported

Early preterm birth < 34 weeks · pregnant women and their babies

The intervention leads to lower early preterm birth < 34 weeks (high certainty).

1 finding from 1 review

Outcomes for all interventions for smoking cessation in pregnancy vs control: subgrouped by main intervention strategy (comparison 20)

Gestational age (preterm birth < 37 weeks) · Pregnant women who smoke

Outcomes for all interventions for smoking cessation in pregnancy showed no clear difference in preterm birth (under 37 weeks) compared with control: subgrouped by main intervention strategy (comparison 20) (high certainty).

1 finding from 1 review

Any supplement containing iodine vs same supplement without iodine or no treatment/placebo (maternal outcomes)

Preterm birth · women during the preconception, pregnancy and postpartum period

Any supplement containing iodine showed no clear difference in preterm birth compared with same supplement without iodine or no treatment/placebo (maternal… (low certainty).

1 finding from 1 review