Cochrane · systematic review · CD011761
Iodine supplementation for women during the preconception, pregnancy and postpartum period
Harding, KB, Peña‐Rosas, JP, Webster, AC, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
Pregnancy and ChildbirthAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
13
current version
GRADE rated
12
No studies
1
Included studies
NR
No studies 1 · 7.7%Ungraded 0 · 0%Very low 3 · 23.1%Low 9 · 69.2%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Any supplement containing iodine versus same supplement without iodine or no treatment/placebo (maternal outcomes)
Population: women during the preconception, pregnancy and postpartum period
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Maternal hypothyroidism ‐ pregnancy Any supplement containing iodine vs same supplement without iodine or no treatment/placebo (maternal outcomes) | RR 1.9 [0.57, 6.38] | 1 study · 365 participants | Low Downgraded: risk of bias, imprecision |
Maternal hypothyroidism ‐ postpartum Any supplement containing iodine vs same supplement without iodine or no treatment/placebo (maternal outcomes) | RR 0.44 [0.06, 3.42] | 3 studies · 540 participants | Low Downgraded: risk of bias |
Preterm birth Any supplement containing iodine vs same supplement without iodine or no treatment/placebo (maternal outcomes) | RR 0.71 [0.3, 1.66] | 2 studies · 376 participants | Low Downgraded: risk of bias, imprecision |
Maternal adverse effect: elevated thyroid peroxidase antibodies ‐ pregnancy Any supplement containing iodine vs same supplement without iodine or no treatment/placebo (maternal outcomes) | RR 0.95 [0.44, 2.07] | 1 study · 359 participants | Low Downgraded: risk of bias, imprecision |
Maternal adverse effect: elevated TPO‐ab ‐ postpartum Any supplement containing iodine vs same supplement without iodine or no treatment/placebo (maternal outcomes) | RR 1.01 [0.78, 1.3] | 3 studies · 397 participants | Low Downgraded: risk of bias, imprecision |
Maternal adverse effect: hyperthyroidism ‐ pregnancy Any supplement containing iodine vs same supplement without iodine or no treatment/placebo (maternal outcomes) | RR 1.9 [0.57, 6.38] | 1 study · 365 participants | Low Downgraded: risk of bias, imprecision |
Maternal adverse effect: hyperthyroidism ‐ postpartum Any supplement containing iodine vs same supplement without iodine or no treatment/placebo (maternal outcomes) | RR 0.32 [0.11, 1.91] | 3 studies · 543 participants | Low Downgraded: risk of bias |
Maternal adverse effect: digestive intolerance ‐ pregnancy Any supplement containing iodine vs same supplement without iodine or no treatment/placebo (maternal outcomes) | RR 15.33 [2.07, 113.7] | 1 study · 76 participants | Very low Downgraded: risk of bias, imprecision |
Any supplement containing iodine versus same supplement without iodine or no treatment/placebo (child outcomes)
Population: women during the preconception, pregnancy and postpartum period
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Perinatal mortality Any supplement containing iodine vs same supplement without iodine or no treatment/placebo (child outcomes) | RR 0.66 [0.42, 1.03] | 1 study · 399 participants | Low Downgraded: risk of bias, imprecision |
Low birthweight Any supplement containing iodine vs same supplement without iodine or no treatment/placebo (child outcomes) | RR 0.56 [0.26, 1.23] | 2 studies · 377 participants | Low Downgraded: risk of bias, imprecision |
Neonatal hypothyroidism or elevated TSH Any supplement containing iodine vs same supplement without iodine or no treatment/placebo (child outcomes) | RR 0.58 [0.11, 3.12] | 1 study · 219 participants | Very low Downgraded: risk of bias, imprecision |
Neonatal adverse effect: elevated TPO‐ab Any supplement containing iodine vs same supplement without iodine or no treatment/placebo (child outcomes) | RR 0.61 [0.07, 5.7] | 1 study · 108 participants | Very low Downgraded: risk of bias, imprecision |
Child adverse effect: hyperthyroidism Any supplement containing iodine vs same supplement without iodine or no treatment/placebo (child outcomes) | no estimate extracted | NR | No studies |