Severe (defined as stage 3 or greater) retinopathy of prematurity ‐ not reported · preterm infants
Lower showed no clear difference in severe retinopathy of prematurity (≥ stage 3) compared with higher oxygen concentrations titrated to target oxygen saturations… (low certainty).
1 finding from 1 review
Inotropic support for hypotension · preterm infants
Respiratory support showed no clear difference in inotropic support for hypotension compared with no respiratory support before cord clamping (low certainty).
1 finding from 1 review
RR 1.25 [0.63, 2.49]
150 participants
Low
Death or use of ECMO; studies that did not allow back‐up use of iNO in controls · respiratory failure in infants born at or near term
Inhaled NO leads to lower death or use of ECMO; studies that did not allow back‐up use of iNO… compared with control (high certainty).
1 finding from 1 review
Death at hospital discharge · respiratory failure in infants born at or near term
Inhaled NO showed no clear difference in death before hospital discharge; studies that did not allow back‐up… compared with control (high certainty).
1 finding from 1 review
Use of ECMO before hospital discharge · respiratory failure in infants born at or near term
Inhaled NO leads to lower use of ECMO before hospital discharge; studies that did not allow… compared with control (high certainty).
1 finding from 1 review
Vitamin A deficiency · mortality and morbidity in term neonates
Neonatal vitamin A supplementation showed no clear difference in vitamin A deficiency (serum retinol < 0.70 micromol/L) at 6 weeks of… compared with control (high certainty).
2 findings from 1 review
Intervention not reported
Retinopathy of prematurity requiring treatment · extremely preterm infants
The intervention probably leads to lower retinopathy of prematurity requiring treatment (moderate certainty).
1 finding from 1 review
Retinopathy of prematurity, any or severe (stage ≥ III) · patients with preventing morbidity and mortality in very preterm infants
It is very uncertain whether cerebral NIRS oximetry changes retinopathy of prematurity, any or severe (stage ≥ III) compared with no cerebral NIRS oximetry (very low certainty).
1 finding from 1 review
Intervention not reported
Vitamin A deficiency: retinol < 0.7 μmol/L · infants 1 to 6 months of age
The intervention showed no clear difference in vitamin A deficiency: retinol < 0.7 μmol/L (moderate certainty).
1 finding from 1 review
Intervention not reported
Duration of iNO therapy (days) · Neonates with PPHN
1 finding from 1 review
no estimate extracted
21 participants
Low
Severe (defined as stage 3 or greater) retinopathy of prematurity ‐ not reported · Parenterally fed preterm infants
All fish oil containing LE showed no clear difference in retinopathy of prematurity (≥ stage 3) compared with S‐LE (low certainty).
1 finding from 1 review
Severe (defined as stage 3 or greater) retinopathy of prematurity ‐ not reported · Parenterally fed preterm infants
It is very uncertain whether all alternative LE changes retinopathy of prematurity (≥ stage 3) compared with S‐LE (very low certainty).
1 finding from 1 review
Severe (defined as stage 3 or greater) retinopathy of prematurity ‐ not reported · Parenterally fed preterm infants
MOFS‐LE showed no clear difference in retinopathy of prematurity (≥ stage 3) compared with S‐LE (low certainty).
1 finding from 1 review
Intervention not reported
Retinopathy of prematurity · preterm or low birth weight infants
The intervention showed no clear difference in retinopathy of prematurity (high certainty).
1 finding from 1 review
Mortality before hospital discharge · preterm infants
Higher showed no clear difference in mortality to hospital discharge compared with lower amino acid intake (low certainty).
1 finding from 1 review
Neurodevelopmental disability · preterm infants
It is very uncertain whether higher changes neurodevelopmental disability compared with lower amino acid intake (very low certainty).
1 finding from 1 review
Postnatal growth failure (weight < 10th percentile) · preterm infants
It is very uncertain whether higher changes postnatal growth failure at discharge (weight < 10th centile) compared with lower amino acid intake (very low certainty).
1 finding from 1 review
Weight gain · preterm infants
1 finding from 1 review
Head circumference gain (mm/week) · preterm infants
1 finding from 1 review
Abnormal blood urea nitrogen (various criteria) · preterm infants
Higher leads to higher abnormal blood urea nitrogen (various criteria) compared with lower amino acid intake (high certainty).
1 finding from 1 review