Cochrane · systematic review · CD009172
Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants
Kapoor, V, Glover, R, Malviya, MN · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
NeonatalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
41
current version
GRADE rated
39
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 2 · 4.9%Very low 15 · 36.6%Low 24 · 58.5%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
MOFS‐LE versus S‐LE for parenterally fed preterm infants
Population: Parenterally fed preterm infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death before discharge MOFS‐LE vs S‐LE | RR 1.26 [0.68, 2.31] | 5 studies · 369 participants | Low Downgraded: risk of bias, imprecision, publication bias |
Days to regain birth weight MOFS‐LE vs S‐LE | no estimate extracted | 3 studies · 234 participants | Low Downgraded: imprecision, publication bias |
Rate of weight gain (g/kg/day) MOFS‐LE vs S‐LE | no estimate extracted | 5 studies · 347 participants | Very low Downgraded: imprecision, publication bias |
Bronchopulmonary dysplasia/chronic lung disease MOFS‐LE vs S‐LE | RR 1.02 [0.7, 1.49] | 4 studies · 314 participants | Low Downgraded: imprecision |
Any sepsis (clinical and/or culture positive) MOFS‐LE vs S‐LE | RR 0.94 [0.62, 1.42] | 5 studies · 346 participants | Low Downgraded: imprecision, publication bias |
Retinopathy of prematurity (≥ stage 3) MOFS‐LE vs S‐LE | RR 0.43 [0.06, 2.85] | 3 studies · 256 participants | Low Downgraded: risk of bias, imprecision |
Parenteral nutrition‐associated liver disease/cholestasis MOFS‐LE vs S‐LE | RR 0.78 [0.29, 2.13] | 4 studies · 314 participants | Low Downgraded: risk of bias, imprecision |
MFS‐LE versus S‐LE for parenterally fed preterm infants
Population: Parenterally fed preterm infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death before discharge MFS‐LE vs S‐LE | RR 5 [0.25, 99.95] | 1 study · 60 participants | Low Downgraded: imprecision |
Days to regain birth weight MFS‐LE vs S‐LE | no estimate extracted | 1 study · 57 participants | Low Downgraded: imprecision |
Rate of weight gain (g/kg/day) MFS‐LE vs S‐LE | no estimate extracted | 1 study · 57 participants | Low Downgraded: imprecision |
Bronchopulmonary dysplasia/chronic lung disease MFS‐LE vs S‐LE | RR 1.39 [0.42, 4.65] | 1 study · 57 participants | Low Downgraded: imprecision |
Any sepsis (clinical and/or culture positive) MFS‐LE vs S‐LE | RR 1.11 [0.31, 4.02] | 1 study · 57 participants | Low Downgraded: imprecision |
Parenteral nutrition‐associated liver disease/cholestasis MFS‐LE vs S‐LE | RR 3.32 [0.14, 78.25] | 1 study · 57 participants | Low Downgraded: imprecision |
OS‐LE versus S‐LE for parenterally fed preterm infants
Population: Parenterally fed preterm infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death before discharge(incidence) OS‐LE vs S‐LE | RR 1 [0.21, 4.82] | 3 studies · 224 participants | Low Downgraded: risk of bias, imprecision, publication bias |
Days to regain birth weight (days) OS‐LE vs S‐LE | no estimate extracted | 3 studies · 223 participants | Low Downgraded: risk of bias, imprecision, publication bias |
Rate of weight gain (g/kg/day) OS‐LE vs S‐LE | no estimate extracted | 2 studies · 123 participants | Low Downgraded: risk of bias, imprecision, publication bias |
Bronchopulmonary dysplasia/chronic lung disease (incidence ‐ variable definition) OS‐LE vs S‐LE | RR 0.69 [0.46, 1.04] | 4 studies · 261 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, publication bias |
Bronchopulmonary dysplasia/chronic lung disease (sensitivity analysis) OS‐LE vs S‐LE | RR 1.01 [0.57, 1.79] | 3 studies · 197 participants | Low Downgraded: risk of bias, imprecision, publication bias |
Duration of ventilation (days) OS‐LE vs S‐LE | no estimate extracted | 3 studies · 202 participants | Very low Downgraded: inconsistency |
Any sepsis (clinical and/or culture positive) OS‐LE vs S‐LE | RR 0.87 [0.56, 1.36] | 5 studies · 301 participants | Very low Downgraded: risk of bias, imprecision, publication bias |
MS‐LE versus S‐LE for parenterally fed preterm infants
Population: Parenterally fed preterm infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death before discharge MS‐LE vs S‐LE | no estimate extracted | 1 study · 60 participants | Ungraded |
Days to regain birth weight MS‐LE vs S‐LE | no estimate extracted | 1 study · 60 participants | Very low Downgraded: imprecision |
Rate of weight gain (g/kg/day) MS‐LE vs S‐LE | no estimate extracted | 1 study · 60 participants | Very low Downgraded: imprecision |
Bronchopulmonary dysplasia/chronic lung disease MS‐LE vs S‐LE | RR 1 [0.28, 3.63] | 1 study · 60 participants | Very low Downgraded: imprecision |
Any sepsis (clinical and/or culture positive) MS‐LE vs S‐LE | RR 2 [0.67, 5.94] | 1 study · 60 participants | Very low Downgraded: imprecision |
Parenteral nutrition‐associated liver disease/cholestasis MS‐LE vs S‐LE | RR 3 [0.13, 70.83] | 1 study · 60 participants | Very low Downgraded: imprecision |
Hypertriglyceridaemia MS‐LE vs S‐LE | no estimate extracted | 1 study · 12 participants | Ungraded |
All fish oil containing LE versus S‐LE for parenterally fed preterm infants
Population: Parenterally fed preterm infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death before discharge All fish oil containing LE vs S‐LE | RR 1.28 [0.69, 2.35] | 5 studies · 399 participants | Low Downgraded: imprecision |
Days to regain birth weight All fish oil containing LE vs S‐LE | no estimate extracted | 3 studies · 261 participants | Low Downgraded: imprecision, publication bias |
Rate of weight gain (g/kg/day) All fish oil containing LE vs S‐LE | no estimate extracted | 5 studies · 374 participants | Very low Downgraded: imprecision, publication bias |
Bronchopulmonary dysplasia/chronic lung disease All fish oil containing LE vs S‐LE | RR 1.02 [0.7, 1.5] | 4 studies · 341 participants | Low Downgraded: imprecision, publication bias |
Any sepsis (clinical and/or culture positive) All fish oil containing LE vs S‐LE | RR 0.92 [0.61, 1.39] | 5 studies · 373 participants | Low Downgraded: imprecision, publication bias |
Retinopathy of prematurity (≥ stage 3) All fish oil containing LE vs S‐LE | RR 0.43 [0.06, 2.85] | 3 studies · 256 participants | Low Downgraded: imprecision |
Parenteral nutrition‐associated liver disease/cholestasis All fish oil containing LE vs S‐LE | RR 0.8 [0.29, 2.16] | 4 studies · 341 participants | Low Downgraded: imprecision, publication bias |
All alternative LE versus S‐LE for parenterally fed preterm infants
Population: Parenterally fed preterm infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death before discharge All alternative LE vs S‐LE | RR 1.17 [0.66, 2.07] | 7 studies · 623 participants | Low Downgraded: risk of bias, imprecision |
Days to regain birth weight All alternative LE vs S‐LE | no estimate extracted | 5 studies · 484 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Rate of weight gain (g/kg/day) All alternative LE vs S‐LE | no estimate extracted | 6 studies · 497 participants | Very low Downgraded: risk of bias, imprecision |
Bronchopulmonary dysplasia/chronic lung disease All alternative LE vs S‐LE | RR 0.84 [0.63, 1.12] | 7 studies · 602 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Any sepsis (clinical and/or culture positive) All alternative LE vs S‐LE | RR 0.9 [0.66, 1.23] | 9 studies · 674 participants | Very low Downgraded: risk of bias, imprecision |
Retinopathy of prematurity (≥ stage 3) All alternative LE vs S‐LE | RR 0.43 [0.06, 2.85] | 3 studies · 256 participants | Very low Downgraded: risk of bias, imprecision |
Parenteral nutrition‐associated liver disease/cholestasis All alternative LE vs S‐LE | RR 0.83 [0.37, 1.86] | 7 studies · 602 participants | Low Downgraded: risk of bias, imprecision |