Remineralisation of early enamel caries · Children with early (incipient) enamel caries
One trial found sodium fluoride gel significantly remineralised early enamel caries; ungraded.
1 finding from 1 review
Remineralisation of early enamel caries · Children with early enamel caries in erupting permanent first molars
One pilot study found 10% silver diamine fluoride worked about as well as glass ionomer restoration and tooth-brushing for remineralising early enamel caries; ungraded.
1 finding from 1 review
Remineralisation of early enamel caries · Children with early enamel caries (permanent dentition)
One trial found 6% sodium fluoride plus 6% calcium fluoride varnish significantly reversed early enamel caries versus no treatment; ungraded and not meta-analysed.
1 finding from 1 review
Serum 25-hydroxyvitamin D level · Children aged 6 years or younger (preschool children)
Preschool children with ECC had significantly lower serum 25(OH)D than caries-free children (WMD -13.96 nmol/l; ungraded).
1 finding from 1 review
Serum 25-hydroxyvitamin D level · Preschool children ≤6 years, Asia
In Asia, children with S-ECC had lower serum 25(OH)D than caries-free children (WMD -19.25 nmol/l; ungraded).
1 finding from 1 review
Serum 25-hydroxyvitamin D level · Preschool children ≤6 years, North America
In North America, children with S-ECC had lower serum 25(OH)D than caries-free children (WMD -13.28 nmol/l; ungraded).
1 finding from 1 review
Serum 25-hydroxyvitamin D level · Children aged 6 years or younger (preschool children)
Children with severe ECC had significantly lower serum 25(OH)D than caries-free children (WMD -18.64 nmol/l; ungraded).
1 finding from 1 review
Development and eruption of the second permanent molar · Children aged 5 to 15 years with a compromised first permanent molar
Root closure and eruption of the second permanent molar appeared accelerated on the extraction side in a single case-control study; ungraded and not statistically tested.
1 finding from 1 review
Caries and/or fillings in adjacent teeth · Children aged 5 to 15 years with a compromised first permanent molar
One study found fewer decayed or filled proximal surfaces but more decayed or filled occlusal surfaces in arches with an extracted first permanent molar; ungraded.
1 finding from 1 review
Spontaneous space closure · Children aged 5 to 15 years with a compromised first permanent molar
Early extraction of a compromised first permanent molar is followed by variable spontaneous closure of the post-extraction space (about 45.5% to 85.2% of cases); certainty was not GRADE-rated (Shekelle category III).
1 finding from 1 review
Caries development in permanent teeth · School children and adolescents (6-18 years) followed from primary dentition (baseline examination before 72 months of age)
Early childhood caries increases the likelihood of caries in permanent teeth roughly three-fold, but the certainty of evidence is very low (OR 3.22, 95% CI 2.80 to 3.71).
1 finding from 1 review
Development and eruption of the third molar · Children aged 5 to 15 years with a compromised first permanent molar
Development and eruption of the third molar appeared accelerated after early first permanent molar extraction in two studies (e.g., eruption OR 2.86, 95% CI 1.37 to 5.96); ungraded.
1 finding from 1 review
OR 2.86 [1.37, 5.96]
2 studies
GRADE not reported
Caries development in permanent teeth · School children and adolescents (6-18 years) followed from primary dentition (baseline examination before 72 months of age)
Early-childhood oral hygiene and dietary habits show inconsistent associations with permanent-teeth caries, often losing significance after adjustment for past caries (2 studies; not pooled; not GRADE-rated).
1 finding from 1 review
Early childhood caries (ECC) · Healthy children under 6 years of age (6 months to 6 years); preschool children
After excluding an extreme outlier (Alhabdan 2018), the association between low brushing frequency and ECC remained statistically significant (pooled OR approximately 2.0, p=0.003; I2=87.5%); the exact estimate and its CI were not reported; ungraded.
2 findings from 1 review
Early childhood caries (ECC) · Children younger than 71 months (under 6 years)
Breastfeeding for more than 12 months is associated with higher ECC prevalence (low certainty).
1 finding from 1 review
OR 1.86 [1.48, 2.35]
13 studies
Low
Early childhood caries (ECC) · Children aged 0-5 years in North Africa
Pooled ECC prevalence in Tunisia was 38% (95% CI 24-51), significantly lower than Egypt and Sudan.
10 findings from 1 review
Prevalence 38 [24, 51]
4 studies
GRADE not reported
Prevalence 48 [39, 58]
9 studies
GRADE not reported
Prevalence 63 [52, 74]
3 studies
GRADE not reported
Show 7 more findings
Early childhood caries (ECC) · Children aged 0-5 years in North Africa
Paternal tertiary education was associated with lower odds of ECC (OR 0.381).
3 findings from 1 review
OR 0.381 [0.16, 0.91]
1 study
GRADE not reported
OR 0.083 [0.03, 0.21]
1 study
GRADE not reported
OR 0.797 [0.171, 0.650]
1 study
GRADE not reported
Caries prevalence (early childhood caries) · Preschool children aged <=71 months (caries outcome assessed at 3-6 years)
Preschool children exposed to secondary smoking have higher odds of caries prevalence (OR 1.77), but the cross-sectional evidence is very uncertain (very low certainty).
2 findings from 1 review
Early childhood caries (ECC) · Children aged 0-5 years in North Africa
Brushing twice daily was associated with lower odds of ECC (OR 0.033).
2 findings from 1 review
OR 0.033 [0.004, 0.276]
1 study
GRADE not reported
OR 0.033 [0.004, 0.263]
1 study
GRADE not reported
Early childhood caries (ECC) · Preschool children (<6 years)
Higher sugar consumption is associated with early childhood caries in children under 6 years: pooled OR 1.59 (95% CI 1.50 to 1.68) from 9 cohort studies with no heterogeneity (I2=0%); the body of evidence was not GRADE-rated (ungraded).
1 finding from 1 review