6% sodium fluoride with 6% calcium fluoride varnish vs no treatment: Remineralisation of early enamel caries
- Population
- Children with early enamel caries (permanent dentition)
- Intervention
- 6% sodium fluoride with 6% calcium fluoride varnish
- Comparison
- no treatment
- Outcome
- Remineralisation of early enamel caries
One trial found 6% sodium fluoride plus 6% calcium fluoride varnish significantly reversed early enamel caries versus no treatment; ungraded and not meta-analysed.
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
6% sodium fluoride with 6% calcium fluoride varnish vs No treatment Reversal / remineralisation of early enamel caries · Children with early enamel caries (permanent dentition) · Children in clinical dental settings One trial found 6% sodium fluoride plus 6% calcium fluoride varnish significantly reversed early enamel caries versus no treatment; ungraded and not meta-analysed. Caries remineralisation and arresting effect in children by professionally applied fluoride treatment - a… (2016) All outcomes | One study (Xhemnica 2008) reported a significant reversal of early enamel caries using 6% NaF with 6% calcium fluoride compared with no treatment; this study was excluded from the meta-analysis. | 1 study | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Caries remineralisation and arresting effect in children by professionally applied fluoride treatment - a systematic review. 2016 All outcomes | Publications from 1948 to 2014 (search date not reported) | 17 | Critically Low / Critically Low |
Studies behind the findings
The primary studies the full-text reviews tie to this outcome. Reviews with headline outcomes only do not list them here.
- Randomized clinical trial on effectiveness of silver diamine fluoride and glass ionomer in arresting dentine caries in preschool children. · 2012 · included by 1 of these review
- Efficacy of silver diamine fluoride for Arresting Caries Treatment. · 2009 · included by 1 of these review
- Fluoride varnish application: a new prophylactic method in Albania. Effect on enamel carious lesions in permanent dentition. · 2008 · included by 1 of these review
- Efficacy of silver diamine fluoride for caries reduction in primary teeth and first permanent molars of schoolchildren: 36-month clinical… · 2005 · included by 1 of these review
- Effectiveness of silver diamine fluoride and sodium fluoride varnish in arresting dentin caries in Chinese pre-school children. · 2002 · included by 1 of these review
- A community-based caries control program for pre-school children using topical fluorides: 18-month results. · 2001 · included by 1 of these review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.