Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,245 questions · 1,274 findings · 321 reviews

No studies found 247 · 19.4%GRADE not reported 195 · 15.3%Very low 372 · 29.2%Low 282 · 22.1%Moderate 141 · 11.1%High 37 · 2.9%

Mirtazapine vs placebo

Participant‐reported sleep problems (scale: 0 to 28; higher scores indicate more sleep problems) · adults with fibromyalgia

Mirtazapine showed no clear difference in participant‐reported sleep problems (scale: 0 to 28; higher scores… compared with placebo (low certainty).

1 finding from 1 review

Standard care plus IV tranexamic acid vs placebo or usual care

Maternal blood loss of 500 mL or greater · women with primary postpartum haemorrhage following vaginal or caesarean birth

Standard care plus IV tranexamic acid may leads to lower blood loss 500 mL or more after randomisation compared with placebo or standard care alone (low certainty).

1 finding from 1 review

Betahistine vs placebo

Tinnitus loudness · patients with subjective idiopathic tinnitus
1 finding from 1 review
  • Betahistine for tinnitus 2018 · Cochrane Headline outcomes only
    no estimate extracted
    2 studies · 81 participants
    Very low

Betahistine vs placebo

Change in tinnitus loudness measured by a visual analogue scale (range 0 to more than 10) · patients with subjective idiopathic tinnitus
1 finding from 1 review

Keratinocyte growth factor (KGF; palifermin or repifermin), intravenous vs placebo

Interruptions to cancer treatment (unscheduled radiotherapy breaks of 5 or more days) · Adults with cancer receiving treatment

Keratinocyte growth factor (KGF; palifermin or repifermin),… showed no clear difference in interruptions to cancer treatment (unscheduled radiotherapy breaks… compared with placebo; GRADE not reported.

1 finding from 1 review

Methotrexate vs placebo

Participants able to reduce corticosteroid or IVIg dose by more than 20% · people with CIDP

Methotrexate showed no clear difference in participants able to reduce corticosteroid or IVIg dose by more than… compared with placebo (moderate certainty).

1 finding from 1 review

Oral or topical or intraperitoneal antibiotics vs placebo/no treatment

Peritonitis · chronic peritoneal dialysis patients

Oral or topical or intraperitoneal antibiotics showed no clear difference in peritonitis (number of patients with one or more episodes) compared with placebo/no treatment (low certainty).

1 finding from 1 review

Any antifungal intervention for the treatment of oral candidiasis vs placebo/no treatment

Fungal peritonitis (number of patients with one or more episodes) · chronic peritoneal dialysis patients

Antifungal may leads to lower fungal peritonitis (number of patients with one or more episodes) compared with placebo/no treatment (low certainty).

1 finding from 1 review

Oral or topical or intraperitoneal antibiotics vs placebo/no treatment

Exit‐site/tunnel infection · chronic peritoneal dialysis patients

Oral or topical or intraperitoneal antibiotics showed no clear difference in exit‐site/tunnel infection (number of patients with one or more… compared with placebo/no treatment (low certainty).

1 finding from 1 review

Topical disinfectants vs standard care or other active treatment (antibiotic or other disinfectant)

Peritonitis · chronic peritoneal dialysis patients

Topical disinfectants showed no clear difference in peritonitis (number of patients with one or more episodes) compared with standard care or other active treatment (antibiotic or other… (low certainty).

1 finding from 1 review