Cochrane · systematic review · CD013093
Betahistine for tinnitus
Wegner, I, Hall, DA, Smit, AL, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
ENTAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
17
current version
GRADE rated
12
No studies
5
Included studies
NR
No studies 5 · 29.4%Ungraded 0 · 0%Very low 5 · 29.4%Low 2 · 11.8%Moderate 5 · 29.4%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Betahistine compared with placebo for tinnitus
Population: patients with subjective idiopathic tinnitus
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Tinnitus loudness measured by a visual analogue scale (range 0 to 10/more than 10) Betahistine vs placebo | no estimate extracted | 2 studies · 81 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Change in tinnitus loudness measured by a visual analogue scale (range 0 to more than 10) Betahistine vs placebo | no estimate extracted | 1 study · 11 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Tinnitus loudness measured by a visual analogue scale (range 0 to 10) Betahistine vs placebo | no estimate extracted | 1 study · 70 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Significant adverse effects (yes or no) Betahistine vs placebo | no estimate extracted | 1 study · 11 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Significant adverse effects (yes or no) Betahistine vs placebo | no estimate extracted | 1 study · 41 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Change in Tinnitus Severity Index (range 0 to 56) Betahistine vs placebo | no estimate extracted | 1 study · 50 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Tinnitus severity score (range 0 to 4) Betahistine vs placebo | no estimate extracted | 1 study · 36 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Depressive symptoms Betahistine vs placebo | no estimate extracted | NR | No studies |
Symptoms of generalised anxiety Betahistine vs placebo | no estimate extracted | NR | No studies |
Other adverse effects (yes or no) Betahistine vs placebo | no estimate extracted | 1 study · 11 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Other adverse effects (yes or no) Betahistine vs placebo | no estimate extracted | 1 study · 41 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Betahistine versus placebo (with concurrent medication)
Population: patients with subjective idiopathic tinnitus
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Change in tinnitus loudness match (range 0 to 5) Betahistine vs placebo (with concurrent medication) | no estimate extracted | 1 study · 60 participants | Moderate Downgraded: risk of bias |
Significant adverse effects (yes or no) Betahistine vs placebo (with concurrent medication) | no estimate extracted | 1 study · 59 participants | Low Downgraded: risk of bias, imprecision |
Tinnitus symptom severity Betahistine vs placebo (with concurrent medication) | no estimate extracted | NR | No studies |
Depressive symptoms Betahistine vs placebo (with concurrent medication) | no estimate extracted | NR | No studies |
Symptoms of generalised anxiety Betahistine vs placebo (with concurrent medication) | no estimate extracted | NR | No studies |
Other adverse effects (yes or no) Betahistine vs placebo (with concurrent medication) | no estimate extracted | 1 study · 59 participants | Moderate Downgraded: risk of bias |