Cochrane · systematic review · CD004679
Antimicrobial agents for preventing peritonitis in peritoneal dialysis patients
Campbell, D, Mudge, DW, Craig, JC, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
Kidney and TransplantAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
10
current version
GRADE rated
10
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 10 · 100%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Oral or topical or intraperitoneal antibiotics versus placebo/no treatment for preventing peritonitis in peritoneal dialysis patients
Population: patients with CKD on peritoneal dialysis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Peritonitis (number of patients with one or more episodes) Oral or topical or intraperitoneal antibiotics vs placebo/no treatment | RR 0.82 [0.57, 1.19] | 5 studies · 395 participants | Low Downgraded: risk of bias, imprecision |
Exit‐site/tunnel infection (number of patients with one or more episodes) Oral or topical or intraperitoneal antibiotics vs placebo/no treatment | RR 0.45 [0.19, 1.04] | 3 studies · 191 participants | Low Downgraded: imprecision |
Catheter removal or replacement (number of patients) Oral or topical or intraperitoneal antibiotics vs placebo/no treatment | RR 0.82 [0.46, 1.46] | 5 studies · 395 participants | Low Downgraded: risk of bias, imprecision |
Nasal antibiotics versus placebo/no treatment for preventing peritonitis in peritoneal dialysis patients
Population: patients with CKD on peritoneal dialysis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Peritonitis (number of patients with one or more episodes) Nasal antibiotics vs placebo/no treatment | RR 0.94 [0.67, 1.31] | 3 studies · 338 participants | Low Downgraded: risk of bias, imprecision |
Exit‐site/ tunnel infection (number of patients with one or more episodes) Nasal antibiotics vs placebo/no treatment | RR 1.34 [0.62, 2.87] | 3 studies · 338 participants | Low Downgraded: risk of bias, imprecision |
Catheter removal or replacement (number of patients) Nasal antibiotics vs placebo/no treatment | RR 0.92 [0.48, 1.78] | 2 studies · 289 participants | Low Downgraded: risk of bias, imprecision |
Topical disinfectants versus standard care or other active treatment (antibiotic or other disinfectant) for preventing peritonitis in peritoneal dialysis patients
Population: patients with CKD on peritoneal dialysis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Peritonitis (number of patients with one or more episodes) Topical disinfectants vs standard care or other active treatment (antibiotic or other disinfectant) | RR 0.83 [0.65, 1.06] | 6 studies · 853 participants | Low Downgraded: risk of bias, imprecision |
Exit‐site/tunnel infection (number of patients with one or more episodes) Topical disinfectants vs standard care or other active treatment (antibiotic or other disinfectant) | RR 0.97 [0.74, 1.27] | 7 studies · 913 participants | Low Downgraded: risk of bias, imprecision |
Catheter removal or replacement (number of patients) Topical disinfectants vs standard care or other active treatment (antibiotic or other disinfectant) | RR 0.89 [0.57, 1.38] | 6 studies · 792 participants | Low Downgraded: risk of bias, imprecision |
Antifungal versus placebo/no treatment for preventing peritonitis in peritoneal dialysis patients
Population: patients with CKD on peritoneal dialysis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Fungal peritonitis (number of patients with one or more episodes) Antifungal vs placebo/no treatment | RR 0.28 [0.12, 0.63] | 2 studies · 817 participants | Low Downgraded: risk of bias, imprecision |