Standard care plus IV tranexamic acid vs placebo or usual care: Maternal blood loss of 500 mL or greater
Standard care plus IV tranexamic acid may leads to lower blood loss 500 mL or more after randomisation compared with placebo or standard care alone (low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Standard care plus IV tranexamic acid vs placebo or standard care alone Blood loss 500 mL or more after randomisation · women with primary postpartum haemorrhage following vaginal or caesarean birth Standard care plus IV tranexamic acid may leads to lower blood loss 500 mL or more after randomisation compared with placebo or standard care alone (low certainty). Antifibrinolytic drugs for treating primary postpartum haemorrhage (2018) · Cochrane Headline outcomes only | RR 0.5 [0.27, 0.93] | 1 study · 151 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Antifibrinolytic drugs for treating primary postpartum haemorrhage 2018 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.