Cochrane · systematic review · CD012964
Antifibrinolytic drugs for treating primary postpartum haemorrhage
Shakur, H, Beaumont, D, Pavord, S, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
Pregnancy and ChildbirthAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 1 · 14.3%Moderate 4 · 57.1%High 2 · 28.6%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Standard care plus IV tranexamic acid compared to placebo or standard care alone for treating primary postpartum haemorrhage
Population: women with primary postpartum haemorrhage following vaginal or caesarean birth
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Maternal mortality due to bleeding Standard care plus IV tranexamic acid vs placebo or standard care alone | RR 0.81 [0.65, 1] | 2 studies · 20172 participants | Moderate |
Maternal mortality (all causes) Standard care plus IV tranexamic acid vs placebo or standard care alone | RR 0.88 [0.74, 1.05] | 2 studies · 20172 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Serious maternal morbidity (any) Standard care plus IV tranexamic acid vs placebo or standard care alone | RR 0.99 [0.83, 1.19] | 1 study · 20015 participants | High |
Blood loss 500 mL or more after randomisation Standard care plus IV tranexamic acid vs placebo or standard care alone | RR 0.5 [0.27, 0.93] | 1 study · 151 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Blood transfusion (any) Standard care plus IV tranexamic acid vs placebo or standard care alone | RR 1 [0.97, 1.03] | 2 studies · 20167 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Surgical intervention to control bleeding: Hysterectomy Standard care plus IV tranexamic acid vs placebo or standard care alone | RR 0.95 [0.81, 1.12] | 1 study · 20017 participants | High |
Side effects of the intervention: Any maternal vascular occlusive event Standard care plus IV tranexamic acid vs placebo or standard care alone | RR 0.88 [0.54, 1.43] | 1 study · 20018 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |