Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,490 questions · 1,526 findings · 124 reviews

No studies found 263 · 17.2%GRADE not reported 224 · 14.7%Very low 292 · 19.1%Low 327 · 21.4%Moderate 286 · 18.7%High 134 · 8.8%

Lateral pararectal vs transrectal enterostomy placement

parastomal hernia (RCT) clinical exam, sonography, intraoperatively, or combination, during stoma reversal · people undergoing enterostomy placement for any reason

Lateral pararectal showed no clear difference in parastomal hernia (RCT) clinical exam, sonography, intraoperatively,… compared with transrectal enterostomy placement (low certainty).

1 finding from 1 review

Calcium supplementation/fortification vs placebo (outcomes

Pre‐eclampsia, or pregnancy loss, or stillbirth (or combination) at any gestational age · women who are not yet pregnant and women in the early stages of pregnancy

Calcium supplementation showed no clear difference in pre‐eclampsia, or pregnancy loss, or stillbirth (or combination) at… compared with placebo (maternal outcomes) commencing before or early (low certainty).

1 finding from 1 review

Intervention not reported

Combination of patient mail and telephone reminder or recall · children, adolescents, and adults with a need for routine immunizations, excluding travel immunizations

The intervention probably leads to higher combination of patient mail and telephone reminder or recall (moderate certainty).

1 finding from 1 review

Intervention not reported

Combination of patient reminder or recall with outreach intervention · children, adolescents, and adults with a need for routine immunizations, excluding travel immunizations

The intervention leads to higher combination of patient reminder or recall with outreach intervention (high certainty).

1 finding from 1 review

Intervention not reported

Combination of patient reminder or recall with provider reminder intervention · children, adolescents, and adults with a need for routine immunizations, excluding travel immunizations

The intervention probably leads to higher combination of patient reminder or recall with provider reminder… (moderate certainty).

1 finding from 1 review

Intervention not reported

Knowledge or understanding (Different measures used by the studies: knowledge of vaccine‐preventable diseases, vaccines, contraindications to vaccination, or a combination, on varying scales) Final time point (3 or 6 months post‐intervention) · parents of preschool‐aged children or expectant parents
1 finding from 1 review

Intervention not reported

Attitudes or beliefs (Different measures used by the studies: perceived severity of vaccine‐preventable diseases, perceived necessity of vaccines, or a combination, on varying scales) Final time point (3 or 6 months post‐intervention) · parents of preschool‐aged children or expectant parents
1 finding from 1 review

NMA evidence for individual network: proportion with complete healing ‐ interventions vs saline gauze

Combination silicone foam dressings · people with pressure ulcers

It is very uncertain whether NMA evidence for individual network: proportion with complete… changes combination silicone foam dressings compared with saline gauze (very low certainty).

1 finding from 1 review

Antihypertensive drug class vs placebo

Beta‐blocker/thiazide combination (any dose) Mean duration of 10 weeks · children (from 1 to 18 years of age) with hypertension from primary or secondary causes
2 findings from 1 review

PROMPT TYPE vs NO PROMPT

Did not attend appointment ‐ combination of telephone and text‐based prompts · people with severe mental disorders

It is very uncertain whether PROMPT TYPE changes did not attend appointment ‐ combination of telephone and text‐based… compared with NO PROMPT (very low certainty).

1 finding from 1 review

Triple therapy vs LABA/LAMA combination

Respiratory HRQoL measured by SGRQ, ≥ 4‐point decrease from baseline (lower scores indicate better HRQoL) · stable COPD

Triple therapy leads to higher respiratory HRQoL measured by SGRQ, ≥ 4‐point decrease from baseline… compared with LABA/LAMA combination (high certainty).

1 finding from 1 review