Cochrane · systematic review · CD006364
Perioperative antibiotics for prevention of acute endophthalmitis after cataract surgery
Gower, EW, Lindsley, K, Tulenko, SE, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
Eyes and VisionAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
12
No studies
2
Included studies
NR
No studies 2 · 14.3%Ungraded 0 · 0%Very low 4 · 28.6%Low 0 · 0%Moderate 6 · 42.9%High 2 · 14.3%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Perioperative antibiotics for prevention of endophthalmitis after cataract surgery
Population: participants undergoing cataract surgery
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Comparison (intervention vs comparator) | no estimate extracted | NR | No studies |
Treatment: BSS with antibiotics (vancomycin 20 mg/mL and gentamicin 8 mg/mL) | no estimate extracted | 644 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Control: BSS‐only irrigating infusion fluid | no estimate extracted | 644 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Treatment 1: combined intracameral cefuroxime and topical levofloxacin | no estimate extracted | 16603 participants | High |
Treatment 2: intracameral cefuroxime 0.9% | no estimate extracted | 16603 participants | High |
Treatment 3: topical levofloxacin 0.5% | no estimate extracted | 16603 participants | Moderate Downgraded: risk of bias, imprecision, indirectness |
Control: placebo drops | no estimate extracted | 16603 participants | Moderate Downgraded: risk of bias, imprecision, indirectness |
Interventions | no estimate extracted | NR | No studies |
Treatment 1: combined prophylaxis (topical regimen + periocular penicillin at the time of surgery) | no estimate extracted | 6618 participants | Moderate Downgraded: risk of bias, imprecision, indirectness |
Treatment 2: topical regimen alone (chloramphenicol‐sulfadimidine) | no estimate extracted | 6618 participants | Moderate Downgraded: risk of bias, imprecision, indirectness |
Mode 1: Anterior sub‐Tenon injections (subconjunctival) | no estimate extracted | 77015 participants | Moderate Downgraded: risk of bias, imprecision, indirectness |
Mode 2: Posterior sub‐Tenon injections (retrobulbar) | no estimate extracted | 77015 participants | Moderate Downgraded: risk of bias, imprecision, indirectness |
Treatment 1: fixed combination of topical gatifloxacin 0.3% and prednisolone acetate 1% | no estimate extracted | 108 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Treatment 2: individual instillation of topical gatifloxacin 0.3% and prednisolone acetate 1% | no estimate extracted | 108 participants | Very low Downgraded: risk of bias, imprecision, indirectness |