Overall survival ‐ Gemcitabine plus other combinations of chemotherapy · advanced pancreatic cancer
Gemcitabine combinations may leads to lower overall survival ‐ Gemcitabine plus other combinations of chemotherapy compared with gemcitabine alone (low certainty).
1 finding from 1 review
Smoking cessation · people who smoke
Combination leads to higher smoking cessation compared with single‐form nicotine replacement therapy (high certainty).
1 finding from 1 review
Overall serious adverse events · people who smoke
Combination showed no clear difference in overall serious adverse events compared with single‐form nicotine replacement therapy (low certainty).
1 finding from 1 review
Treatment withdrawal · people who smoke
It is very uncertain whether combination changes treatment withdrawals compared with single‐form nicotine replacement therapy (very low certainty).
1 finding from 1 review
Overall survival · people with advanced gastric cancer
Combination probably leads to lower overall survival compared with single‐agent chemotherapy (moderate certainty).
1 finding from 1 review
Tumour response · people with advanced gastric cancer
Combination leads to higher tumour response compared with single‐agent chemotherapy (high certainty).
1 finding from 1 review
Time to progression · people with advanced gastric cancer
Combination probably leads to lower time to progression compared with single‐agent chemotherapy (moderate certainty).
1 finding from 1 review
Treatment‐related death · people with advanced gastric cancer
Combination showed no clear difference in treatment‐related death compared with single‐agent chemotherapy (moderate certainty).
1 finding from 1 review
ACR 50 response of DMARDs naive patients Number of responders · patients with rheumatoid arthritis
MTX combination showed no clear difference in ACR 50 response of DMARDs naive patients Number of responders compared with MTX monotherapy (low certainty).
1 finding from 1 review
ACR 50 response of MTX inadequate responders number of responders · patients with rheumatoid arthritis
MTX combination probably leads to higher ACR 50 response of MTX inadequate responders number of responders compared with MTX monotherapy (moderate certainty).
1 finding from 1 review
ACR 50 response of non‐MTX DMARDs inadequate responders number of responders · patients with rheumatoid arthritis
MTX combination showed no clear difference in ACR 50 response of non‐MTX DMARDs inadequate responders number of… compared with MTX monotherapy (moderate certainty).
1 finding from 1 review
Withdrawal due to lack of efficacy or toxicity of DMARDs naive patients number of withdrawals · patients with rheumatoid arthritis
MTX combination showed no clear difference in withdrawal due to lack of efficacy or toxicity of DMARDs naive… compared with MTX monotherapy (moderate certainty).
1 finding from 1 review
Withdrawal due to lack of efficacy or toxicity of MTX inadequate responders number of withdrawals · patients with rheumatoid arthritis
MTX combination showed no clear difference in withdrawal due to lack of efficacy or toxicity of MTX inadequate… compared with MTX monotherapy (moderate certainty).
1 finding from 1 review
Withdrawal due to lack of efficacy or toxicity of non‐MTX DMARDs inadequate responders number of withdrawals · patients with rheumatoid arthritis
It is very uncertain whether MTX combination changes withdrawal due to lack of efficacy or toxicity of non‐MTX DMARDs… compared with MTX monotherapy (very low certainty).
1 finding from 1 review
Withdrawals due to adverse events · patients with rheumatoid arthritis
It is very uncertain whether MTX combination changes withdrawal due to adverse reactions (Pooled across regimens) number… compared with MTX monotherapy (very low certainty).
1 finding from 1 review
Total mortality · people with primary hypertension
It is very uncertain whether combination therapy changes total mortality compared with monotherapy (very low certainty).
1 finding from 1 review
Cardiovascular mortality · people with primary hypertension
1 finding from 1 review
Cardiovascular events · people with primary hypertension
It is very uncertain whether combination therapy changes cardiovascular events compared with monotherapy (very low certainty).
1 finding from 1 review
Serious adverse events · people with primary hypertension
It is very uncertain whether combination therapy changes serious adverse events compared with monotherapy (very low certainty).
1 finding from 1 review
Withdrawals due to adverse events · people with primary hypertension
It is very uncertain whether combination therapy changes withdrawals due to adverse effects compared with monotherapy (very low certainty).
1 finding from 1 review