Cochrane · systematic review · CD004302
Ciliary neurotrophic factor (CNTF) for amyotrophic lateral sclerosis or motor neuron disease
Bongioanni, P, Reali, C, Sogos, V · Cochrane Database of Systematic Reviews · 2004 · Cochrane Library
NeuromuscularAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 7 · 100%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Any CNTF versus placebo for amyotrophic lateral sclerosis or motor neuron disease
Population: patients with amyotrophic lateral sclerosis or motor neuron disease
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Deaths Any CNTF vs placebo | RR 1.07 [0.81, 1.41] | 2 studies · 1300 participants | High |
Muscle strength change from baseline value of isometric muscle strength (combination megascore) Any CNTF vs placebo | no estimate extracted | 2 studies · 1300 participants | High |
Respiratory function (FVC %) change from baseline measures of forced vital capacity as a percentage of the predicted value (FVC %) Any CNTF vs placebo | no estimate extracted | 2 studies · 1300 participants | High |
Changes in quality of life (SIP) change in Sickness Impact Profile (SIP) scores (range from 0 = best health to 100 = worst health). Any CNTF vs placebo | no estimate extracted | 1 study · 503 participants | High |
Asthenia Any CNTF vs placebo | RR 1.02 [0.81, 1.28] | 1 study · 570 participants | High |
Nausea Any CNTF vs placebo | RR 1.35 [0.92, 1.99] | 1 study · 570 participants | High |
Increased salivation Any CNTF vs placebo | RR 1.08 [0.78, 1.5] | 1 study · 570 participants | High |