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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
10,375 questions in 429 reviews · Oral Health
current versionsNo studies 1,344 · 13%Ungraded 6,832 · 65.9%Very low 1,228 · 11.8%Low 613 · 5.9%Moderate 290 · 2.8%High 68 · 0.7%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Maternal smoking during pregnancy vs No maternal smoking during pregnancy Dental caries in children · Children of mothers assessed for smoking status during pregnancy (early childhood dental caries) · Exposure during pregnancy; caries assessed in early childhood, Study region: Europe Maternal smoking during pregnancy and early childhood dental caries in children: a systematic review and… (2024) | OR 1.67 [1.40, 1.99] | 4 studies | Ungraded |
Children with severe early childhood caries (S-ECC) vs Caries-free children Serum 25-hydroxyvitamin D level · Preschool children ≤6 years, Asia · Asia The Association Between Vitamin D and Early Childhood Caries: A Systematic Review and Meta-Analysis. (2024) | MD -19.25 [-20.75, -17.76] | NR | Ungraded |
Facemask (RME) or modified facemask vs Other non-surgical orthodontic treatments (mini maxillary protractor, Pushing Splints, modified tandem, Reverse Forsus, reverse Twin Block, reverse chin cup, tongue appliance, Frankel III) ANB · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion) · End of treatment Orthodontic treatment for prominent lower front teeth (Class III malocclusion) in children (2024) · Cochrane | MD 0.11 [-0.54, 0.77] | 8 studies · 285 participants | Very low |
Periodontitis / periodontal disease (history or clinical diagnosis) vs No periodontitis (individuals without periodontal disease) Oral cancer (OC) · Adults in case-control studies of oral cancer; people assessed for periodontitis · Not specified, Overall (random-effects pooled estimate) Periodontitis and the risk of oral cancer: a meta-analysis of case-control studies. (2024) | OR 2.94 [2.13, 4.07] | 8 studies · 6927 participants | Low |
Silver diamine fluoride (SDF) vs Placebo or no treatment Caries arrest · Children and adults (with or without carious lesions) · 36 months, Permanent dentition (coronal) Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults (2024) · Cochrane | MD 0.20 [0.00, 0.40] | 1 study · 373 participants | Very low |
Extraction at patient age 11-12 years vs Extraction at patient age 8-10 years Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar) · Until eruption of the permanent second molar (median follow-up 4.0 years), Mandible Spontaneous space closure after extraction of permanent first molars in children and adolescents: a… (2024) | OR 0.29 [0.11, 0.81] | 2 studies | Ungraded |
Pentoxifylline vs Multivitamin Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF) Interventions for managing oral submucous fibrosis (2024) · Cochrane | Rajendran 2006 (pentoxifylline 14 vs multivitamins 15): reported increased interincisal distance in the pentoxifylline group but no baseline data, so change could not be determined; excluded from meta-analysis. | 1 study · 29 participants | Ungraded |
Second molar at Nolla developmental stage 6-7 at extraction vs Second molar at later Nolla stages at extraction Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar) · Until eruption of the permanent second molar (median follow-up 4.0 years), Mandible Spontaneous space closure after extraction of permanent first molars in children and adolescents: a… (2024) | OR 55.1 [3.0, at least 100.0] | 1 study | Ungraded |
Oxitard (antioxidant) vs Aloe vera gel Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF) · Less than 3 months Interventions for managing oral submucous fibrosis (2024) · Cochrane | MD 9.40 [8.52, 10.28] | 1 study · 120 participants | Low |
Cesarean section delivery vs Vaginal delivery Early childhood caries (ECC) · Children aged <6 years · Study quality (NOS): Moderate RETRACTED: The association between mode of childbirth delivery and early childhood caries: A comprehensive… (2024) | OR 1.10 [0.75, 1.61] | 12 studies | Ungraded |
TiO2-modified composite (1 wt.%) vs Control composite in contralateral quadrant Streptococcus mutans population · Patients undergoing fixed orthodontic treatment · 1 to 6 months after bonding Can Orthodontic Adhesive Systems Inhibit the Formation and Development of White Spot Lesions During Fixed… (2024) | No statistically significant difference between the S. mutans populations on the control and test sides at any time point. | 1 study · 40 participants | Ungraded |
Facemask (RME) or modified facemask vs Surgically-anchored appliance (miniscrews or miniplates) Overjet · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion) · End of treatment Orthodontic treatment for prominent lower front teeth (Class III malocclusion) in children (2024) · Cochrane | MD -0.40 [-1.30, 0.50] | 1 study · 43 participants | Very low |
Dietary advice on how to achieve a healthy diet for infants (tailored advice focused on a diet low in saturated fat and cholesterol intake) vs Standard care Mother self-reported oral health behaviours · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes,… Interventions with pregnant women, new mothers and other primary caregivers for preventing early childhood… (2024) · Cochrane | Data from Lapinleimu 1995 on mother oral health behaviour (other data) showed some evidence of benefit in favour of the intervention. | 1 study | Ungraded |
Occlusal splint vs Physical therapy (ultrasound, exercise, sensorimotor training, laser, TENS, manual therapy) Recurrence rate · People with temporomandibular disorders (TMD) Occlusal interventions for managing temporomandibular disorders (2024) · Cochrane | Listed in Summary of findings 3 as 'Not reported'; this outcome was not reported by any included study for this comparison. | 0 studies | No studies |
Fixed orthodontic treatment with fixed (multibracket) appliances (exposure) vs None (single-group prevalence/incidence estimate) Association between orthodontic treatment duration and ICLs prevalence · Patients (permanent dentition) during or after fixed orthodontic treatment with fixed (multibracket) appliances · During or after fixed orthodontic treatment, By orthodontic treatment duration (subgroup meta-analysis; positive association, P=.01) Distribution of initial caries lesions in relation to fixed orthodontic therapy. A systematic review and… (2024) | Prevalence of ICLs positively associated with orthodontic treatment duration (meta-regression, P=.01); effect size/slope not available (Fig. 6a image not provided) | NR | Ungraded |
SDF (given at a particular frequency, concentration, or duration) vs SDF (given at a different frequency, concentration, or duration) Aesthetics · Children and adults (with or without carious lesions) · 24 months, Children Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults (2024) · Cochrane | 1 study (119 children) reported that 45% parents were satisfied with child's dental appearance (data not reported by study group) | 1 study · 119 participants | Very low |
Cesarean section delivery vs Vaginal delivery Early childhood caries (ECC) · Children aged <6 years · Sample size: <300 RETRACTED: The association between mode of childbirth delivery and early childhood caries: A comprehensive… (2024) | OR 1.09 [0.64, 1.86] | 13 studies | Ungraded |
Probiotics (any strain, dose, or presentation), minimum intake duration 0.2 months vs No treatment or placebo (control) Number of dental caries (carious pieces) · Adolescents (12-18 years) without background systemic disease · Population: adolescents (vs children; p-interaction=0.02) Efficacy of Probiotic Consumption on Oral Outcomes in Children and/or Adolescents: A Meta-Analysis. (2024) | MD -0.60 [-0.92, -0.28] | NR | Ungraded |
Breastfeeding promotion and support (e.g. individually tailored home-based peer counselling on the importance of breastfeeding, with advice and support for healthy breastfeeding) vs Standard care Caries presence in primary teeth · For interventions, pregnant and lactating women; for outcomes, children up to 6 years of age · Children assessed at 5-6 yrs Interventions with pregnant women, new mothers and other primary caregivers for preventing early childhood… (2024) · Cochrane | RR 0.96 [0.89, 1.03] | 2 studies · 1148 participants | Low |
Facemask with rapid maxillary expansion (RME) vs Facemask with alternating rapid maxillary expansion and constriction (Alt-RAMEC) Overjet · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion) Orthodontic treatment for prominent lower front teeth (Class III malocclusion) in children (2024) · Cochrane | SoF5 (Facemask (Alt-RAMEC) vs facemask (RME)): Overjet - Not measured. | 0 studies | No studies |
High-frequency sugar consumption (three or more times daily) vs Low sugar intake (fewer than three times daily) Dental caries experience in primary dentition (early childhood caries) · Nigerian children with primary dentition (approximately 6 months to 5 years) · Primary dentition A systematic review and meta-analysis of the association between sugar intake and dental caries in Nigeria. (2024) | OR 1.13 [0.23, 5.44] | 2 studies | Ungraded |
Clearfil Protect Bond antibacterial fluoride-releasing primer vs Transbond XT conventional primer White spot lesion incidence · Patients undergoing fixed orthodontic treatment · Before and after orthodontic treatment Can Orthodontic Adhesive Systems Inhibit the Formation and Development of White Spot Lesions During Fixed… (2024) | The incidence of WSLs in the Clearfil (CF) group was 8.03%, while in the Transbond (TB) group, it was 9.24% with no significant difference (p = 0.82). | 1 study · 35 participants | Ungraded |
Silver diamine fluoride (SDF) vs Glass ionomer cement (GIC) plus fluoride varnish Aesthetics · Children and adults (with or without carious lesions) Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults (2024) · Cochrane | No studies reported data for this outcome in this comparison | 0 studies | No studies |
NiTi arch wire of one cross-sectional size vs NiTi arch wire of a different cross-sectional size Root resorption · People receiving orthodontic treatment with fixed appliances (upper and/or lower full arch) Initial arch wires used in orthodontic treatment with fixed appliances (2024) · Cochrane | Root resorption: not reported | 0 studies | No studies |
Periodontitis vs No periodontitis (periodontal health or gingivitis) Mean DMFT (decayed, missing, filled teeth) · Adults · Overall Association between periodontitis and dental caries: a systematic review and meta-analysis. (2024) | WMD 0.87 [-0.03, 1.76] | 4 studies | Ungraded |
Pulpotomy (full or partial) vs None (single-arm success proportion) Overall success (composite of clinical and radiographic success) · Permanent teeth with carious pulp exposure · >=12 months, Normal pulp/reversible pulpitis Efficacy of pulpotomy for permanent teeth with carious pulp exposure: A systematic review and meta-analysis… (2024) | Proportion 0.920 [0.879, 0.954] | NR | Ungraded |
Highest BMI category (overweight/obese) vs Lowest BMI category (normal weight/underweight) Dental caries / early childhood caries (ECC) · Children (approx. 4-18 years) · Country population: large Childhood obesity in relation to risk of dental caries: a cumulative and dose-response systematic review and… (2024) | OR 1.56 [1.09, 2.21] | 9 studies | Ungraded |
Silver diamine fluoride (SDF) vs Sealants or resin infiltration Secondary prevention of caries · Children and adults (with or without carious lesions) · 24 months, Primary dentition (coronal) Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults (2024) · Cochrane | OR 2.76 [0.67, 11.43] | 1 study · 75 participants | Ungraded |
Presence of oral Candida albicans vs Absence of oral Candida albicans Early childhood caries (ECC) · Children aged ≤6 years (early childhood) · Exposure and outcome assessed concurrently (observational); children aged ≤6 years, Study quality (NOS): good RETRACTED: Investigating the association between Candida albicans and early childhood dental caries: A… (2024) | OR 5.32 [2.89, 9.80] | 7 studies | Ungraded |
Occlusal splint vs No treatment or placebo (non-occlusal or transparent-foil placebo splint) Discomfort · People with temporomandibular disorders (TMD) Occlusal interventions for managing temporomandibular disorders (2024) · Cochrane | Listed in Summary of findings 1 as 'Not reported'; this outcome was not reported by any included study for this comparison. Discomfort was not reported in any included study across the whole review. | 0 studies | No studies |
Maternal smoking during pregnancy vs No maternal smoking during pregnancy Dental caries in children · Children of mothers assessed for smoking status during pregnancy (early childhood dental caries) · Exposure during pregnancy; caries assessed in early childhood, Dental examination: Visual/tactile examination Maternal smoking during pregnancy and early childhood dental caries in children: a systematic review and… (2024) | OR 1.48 [1.26, 1.74] | 4 studies | Ungraded |
Not applicable (single-group prevalence) vs Not applicable (single-group prevalence) Early childhood caries experience (mean dmft) · Children younger than 71 months (under 6 years) · GNI <$5000 A systematic review and meta-analysis on early-childhood-caries global data. (2024) | MEAN 4.64 [3.38, 5.91] | 19 studies | Ungraded |
Silver diamine fluoride (SDF) plus fluoride varnish vs Sealants plus fluoride varnish (with or without restorations) Caries arrest · Children and adults (with or without carious lesions) · 24 months, Mixed dentition (coronal) Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults (2024) · Cochrane | MD 0.11 [-0.01, 0.22] | 1 study · 413 participants | Low |
Facemask with rapid maxillary expansion (RME) vs Facemask with alternating rapid maxillary expansion and constriction (Alt-RAMEC) A-Nasion perpendicular (A-NPerp) · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion) · End of treatment Orthodontic treatment for prominent lower front teeth (Class III malocclusion) in children (2024) · Cochrane | MD 1.13 [0.23, 2.03] | 1 study · 34 participants | Ungraded |
Opal Seal fluoride-releasing primer vs Conventional Transbond XT primer DIAGNOdent white spot lesion measurement · Patients undergoing fixed orthodontic treatment · During orthodontic treatment Can Orthodontic Adhesive Systems Inhibit the Formation and Development of White Spot Lesions During Fixed… (2024) | Opal Seal group showed fewer WSLs compared to the Transbond group, with initial demineralization rates of 1.3% and 3.9%, and caries lesion rates of 0.2% and 1.3%, respectively (p <0.03). | 1 study · 56 participants | Ungraded |
Slum residence vs Non-slum urban residence Periodontal pocket (odds), slum vs non-slum residence · Adult residents of slums and non-slum urban settings of LMICs · Cross-sectional, Slum vs non-slum urban (Osuh 2022, Nigeria) Systematic review of oral health in slums and non-slum urban settings of Low and Middle-Income Countries… (2024) | OR 1.50 [1.13, 1.98] | 1 study · 1357 participants | Ungraded |
Periodontitis vs No periodontitis (periodontal health or gingivitis) Dental caries (prevalence) · Adults · Standard periodontitis definition Association between periodontitis and dental caries: a systematic review and meta-analysis. (2024) | OR 1.62 [1.20, 2.18] | 8 studies | Ungraded |
Occlusal splint vs Another occlusal splint with a different mechanism of action Self-reported joint pain when chewing · People with temporomandibular disorders (TMD) Occlusal interventions for managing temporomandibular disorders (2024) · Cochrane | Listed in Summary of findings 2 as 'Not reported'; this outcome was not reported by any included study for this comparison. | 0 studies | No studies |
Male sex vs Female sex Dental caries risk · Institutionalized orphan children · Overall (pooled) Caries in orphan children: prevalence and determinants-a systematic review and meta-analysis. (2024) | RR 1.02 [0.96, 1.08] | 5 studies · 2750 participants | Very low |
Grape seed extract or grape seed flavonoid fractions vs No extract or vehicle control; other antimicrobial agents Biofilm morphology · Streptococcus mutans cultures and biofilms Effect of flavonoids from grape seed and cranberry extracts on the microbiological activity of Streptococcus… (2024) | no estimate extracted | 2 studies | Ungraded |
Silver diamine fluoride (SDF) vs Restoration (restorative treatment) Aesthetics · Children and adults (with or without carious lesions) · 6 to 12 months, Children Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults (2024) · Cochrane | Cleary 2022 reported no significant differences (P > 0.05) in parental acceptability, satisfaction, and preference between treatments at 6 and 12 months; at 12 months children in the restoration arm felt happier with… | 1 study | Very low |
Facemask with rapid maxillary expansion (RME) vs Tongue appliance ANB · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion) · End of treatment Orthodontic treatment for prominent lower front teeth (Class III malocclusion) in children (2024) · Cochrane | MD -0.60 [-1.41, 0.21] | 1 study · 47 participants | Ungraded |
Grape seed extract (GSE) and its proanthocyanidin fractions vs Untreated or vehicle control (some studies vs positive antimicrobial controls, e.g. chlorhexidine/fluoride) Bacterial adhesion (inhibition) · Streptococcus mutans (in vitro cultures and biofilms) Effect of flavonoids from grape seed and cranberry extracts on the microbiological activity of Streptococcus… (2024) | GSE inhibited S. mutans adhesion to hydroxyapatite by 81.5% (polymeric PAC, 0.125 mg/mL) vs 25% for dealcoholized wine (Daglia); adhesion decreased at MIC 0.5 mg/mL (Smullen). | 2 studies | Ungraded |
Opal Seal fluoride-releasing primer vs Conventional Transbond XT primer Photographic white spot lesion severity · Patients undergoing fixed orthodontic treatment · During orthodontic treatment Can Orthodontic Adhesive Systems Inhibit the Formation and Development of White Spot Lesions During Fixed… (2024) | WSL severity in digital photographs: no significant difference between the two groups (p >0.05). | 1 study · 56 participants | Ungraded |
Facemask with rapid maxillary expansion (RME) vs Modified tandem appliance ANB · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion) · End of treatment Orthodontic treatment for prominent lower front teeth (Class III malocclusion) in children (2024) · Cochrane | MD 0.25 [-0.39, 0.89] | 1 study · 32 participants | Ungraded |
Resin-modified glass-ionomer cement (RM-GIC) for bracket bonding vs Conventional composite resin adhesive (Transbond XT) New white spot lesion incidence (and first-time bracket bond failure) · Patients undergoing fixed orthodontic (fixed appliance) treatment (adolescents and adults, ages 12 to 35) · During fixed appliance treatment Can Orthodontic Adhesive Systems Inhibit the Formation and Development of White Spot Lesions During Fixed… (2024) | Benson 2019 (1 multicenter single-blind RCT, 197 patients): no difference in the proportion of patients with new WSLs or first-time bracket failures between RM-GIC and resin adhesive (p>0.05). No meta-analysis performed. | 1 study · 197 participants | Ungraded |
Superelastic NiTi arch wire vs Thermoelastic NiTi arch wire Root resorption (reduction in root length) · People receiving orthodontic treatment with fixed appliances (upper and/or lower full arch) · 16 weeks Initial arch wires used in orthodontic treatment with fixed appliances (2024) · Cochrane | MD -0.05 [-0.14, 0.04] | 2 studies · 52 participants | Very low |
Pulpotomy (full or partial) vs None (single-arm success proportion) Overall success (composite of clinical and radiographic success) · Permanent teeth with carious pulp exposure · 12 months, 12-month follow-up Efficacy of pulpotomy for permanent teeth with carious pulp exposure: A systematic review and meta-analysis… (2024) | Proportion 0.856 | NR | Ungraded |
Silver diamine fluoride (SDF) plus fluoride varnish vs Sealants plus fluoride varnish (with or without restorations) Aesthetics · Children and adults (with or without carious lesions) Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults (2024) · Cochrane | No studies reported data for this outcome in this comparison | 0 studies | No studies |
Silver diamine fluoride (SDF) vs Atraumatic restorative treatment (ART) with glass ionomer cement (GIC) or glass ionomer material Secondary prevention of caries · Children and adults (with or without carious lesions) · Primary and permanent dentition Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults (2024) · Cochrane | No studies reported this outcome | 0 studies | No studies |