Findings

What do systematic reviews say?

1,324 questions · 1,405 findings · 189 reviews

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No studies found 402 · 28.6%GRADE not reported 294 · 20.9%Very low 323 · 23%Low 232 · 16.5%Moderate 117 · 8.3%High 37 · 2.6%

Antidepressants vs any other pharmacological intervention

Acceptability ‐ total dropouts · women of any age, with PND up to 12 months

It is very uncertain whether antidepressants changes treatment acceptability ‐dropouts compared with any other pharmacological intervention (very low certainty).

1 finding from 1 review

Antidepressant treatment for postnatal depression 2021 · Cochrane Headline outcomes only
RR 1.74 [0.99, 3.06]
Studies not reported
Very low

Antidepressants vs any other pharmacological intervention

Child‐related outcomes · women of any age, with PND up to 12 months

The review found no eligible studies for this question.

1 finding from 1 review

Antidepressant treatment for postnatal depression 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Antifibrinolytic therapy (tranexamic acid or epsilon aminocaproic acid) vs Placebo, no intervention or usual care (with or without placebo)

Any postoperative complication except bleeding (e.g. wound infection) · People with haemophilia (A or B) undergoing minor oral surgery or dental extractions

The review found no eligible studies for this question.

1 finding from 1 review

Antifibrinolytic therapy for preventing oral bleeding in patients with haemophilia or Von Willebrand disease… 2019 · Cochrane All outcomes
This outcome was not reported in either of the trials.
0 studies
No studies found

Staple food fortified with vitamin A plus other micronutrients vs no intervention

Any adverse effects (e.g. hypervitaminosis A, as defined by the trialists) · general population over 2 years of age

The review found no eligible studies for this question.

1 finding from 1 review

Fortification of staple foods with vitamin A for vitamin A deficiency 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Antibiotics vs no intervention

Neonatal mortality · newborns with congenital syphilis

Antibiotic treatment showed no clear difference in neonatal death rate due any cause compared with no intervention (low certainty).

1 finding from 1 review

Antibiotic treatment for newborns with congenital syphilis 2019 · Cochrane Headline outcomes only
RR 0.83 [0.06, 11.7]
1 study · 22 participants
Low

Probiotics administered exclusively after birth in mothers of preterm infants vs placebo or no intervention

Necrotising enterocolitis · preterm infants

Probiotics administered exclusively after birth in mothers of… showed no clear difference in any necrotizing Enterocolitis (NEC) compared with maternal placebo or no intervention (low certainty).

1 finding from 1 review

Maternal probiotic supplementation for prevention of morbidity and mortality in preterm infants 2018 · Cochrane Headline outcomes only
RR 0.44 [0.13, 1.46]
1 study · 58 participants
Low

Home (point‐of‐use) fortification of foods with multiple micronutrient powders vs placebo or no intervention

Any adverse effects (e.g. hypervitaminosis A, as defined by the trialists) · preschool and school‐age children

Point‐of‐use fortification of foods with micronutrients powders (MNP) showed no clear difference in adverse effects (any, as defined by trialists) compared with no intervention or placebo (moderate certainty).

1 finding from 1 review

Point‐of‐use fortification of foods with micronutrient powders containing iron in children of preschool and school‐age 2017 · Cochrane Headline outcomes only
RR 1.09 [0.16, 7.42]
1 study · 90 participants
Moderate

Thromboelastography (TEG) or thromboelastometry (ROTEM) vs any comparison

Rate of surgical reintervention · adults or children with bleeding

Thromboelastography (TEG) or thromboelastometry (ROTEM) showed no clear difference in rate of surgical reintervention compared with any comparison (low certainty).

1 finding from 1 review

Thromboelastography (TEG) or thromboelastometry (ROTEM) to monitor haemostatic treatment versus usual care in adults… 2016 · Cochrane Headline outcomes only
RR 0.75 [0.5, 1.1]
9 studies · 887 participants
Low

SSRIs or SNRIs vs amitriptyline

Participants who withdraw because of an adverse event or any other reason · patients for whom migraine preventive interventions are indicated

SSRIs or SNRIs showed no clear difference in withdrawn (for any reasons and due to adverse events) compared with amitriptyline (low certainty).

1 finding from 1 review

Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
OR 0.39 [0.1, 1.5]
1 study · 64 participants
Low

Resin composite restorations containing antibacterial agents vs Non-antibacterial containing composite restorations

Costs (direct costs of interventions) · Adults and adolescents in any age group with restorations in the permanent dentition and children with restorations in the primary dentition

The review found no eligible studies for this question.

1 finding from 1 review

Antibacterial agents in composite restorations for the prevention of dental caries 2013 · Cochrane All outcomes
No studies were included in this review, as we were unable to find any trials directly comparing antibacterial containing composites to other active interventions or controls.
0 studies
No studies found

Urokinase (any strength) vs placebo

Restored patency · patients with occluded central venous catheter

Urokinase (any strength) may leads to higher restored patency compared with placebo (low certainty).

1 finding from 1 review

Interventions for restoring patency of occluded central venous catheter lumens 2012 · Cochrane Headline outcomes only
RR 2.09 [1.47, 2.95]
2 studies · 287 participants
Low

Urokinase (any strength) vs placebo

Adverse effects · patients with occluded central venous catheter

It is very uncertain whether urokinase (any strength) changes adverse effects compared with placebo (very low certainty).

1 finding from 1 review

Interventions for restoring patency of occluded central venous catheter lumens 2012 · Cochrane Headline outcomes only
RR 2.88 [0.38, 21.93]
1 study · 72 participants
Very low

Technology‐mediated psychoeducation vs usual care

Leaving the study early · schizophrenia

It is very uncertain whether technology‐mediated psychoeducation changes compliance/satisfaction: leaving the study early ‐ any reason compared with standard care intervention (very low certainty).

1 finding from 1 review

Information and communication technology in patient education and support for people with schizophrenia 2012 · Cochrane Headline outcomes only
RR 1.24 [0.81, 1.88]
2 studies · 116 participants
Very low

Ozone applied to the carious lesion (10 or 40 seconds), with a fluoride reductant and oral hygiene/preventive advice vs No ozone, with a fluoride reductant and oral hygiene/preventive advice (as in the intervention group)

Adverse events · People of any age with caries (including demineralisation in non-cavitated carious lesions); the caries may affect any single tooth…

1 finding from 1 review

Ozone therapy for the treatment of dental caries 2004 · Cochrane All outcomes
To 6 months
Baysan 2003 stated that no adverse events were reported to 6 months; no information was provided by Abu-Naba'a 2003 or Abu-Naba'a 2003pilot.
1 study
GRADE not reported

Ozone applied to the carious lesion (10 or 40 seconds), with a fluoride reductant and oral hygiene/preventive advice vs No ozone, with a fluoride reductant and oral hygiene/preventive advice (as in the intervention group)

Patient satisfaction · People of any age with caries (including demineralisation in non-cavitated carious lesions); the caries may affect any single tooth…

1 finding from 1 review

Ozone therapy for the treatment of dental caries 2004 · Cochrane All outcomes
Abu-Naba'a 2003 reported participants' state of anxiety, comparing ozone treatment with traditional dental interventions (injection, drilling, filling); because no participant was randomised between ozone and drilling…
1 study
GRADE not reported

Ozone applied to the carious lesion (10 or 40 seconds), with a fluoride reductant and oral hygiene/preventive advice vs No ozone, with a fluoride reductant and oral hygiene/preventive advice (as in the intervention group)

Further conventional dental treatment (filling and drilling) (binary yes/no) · People of any age with caries (including demineralisation in non-cavitated carious lesions); the caries may affect any single tooth…

The review found no eligible studies for this question.

1 finding from 1 review

Ozone therapy for the treatment of dental caries 2004 · Cochrane All outcomes
Data were not provided by any study on the number of lesions requiring restorations to 6 months or later; no data on any further conventional treatment or other dental interventions.
Studies not reported
No studies found

Ozone applied to the carious lesion (10 or 40 seconds), with a fluoride reductant and oral hygiene/preventive advice vs No ozone, with a fluoride reductant and oral hygiene/preventive advice (as in the intervention group)

Costs · People of any age with caries (including demineralisation in non-cavitated carious lesions); the caries may affect any single tooth…

The review found no eligible studies for this question.

1 finding from 1 review

Ozone therapy for the treatment of dental caries 2004 · Cochrane All outcomes
No data were provided in any of the included trials on costs.
Studies not reported
No studies found

Ozone applied to the carious lesion (10 or 40 seconds), with a fluoride reductant and oral hygiene/preventive advice vs No ozone, with a fluoride reductant and oral hygiene/preventive advice (as in the intervention group)

Pain (assessed by the patient) · People of any age with caries (including demineralisation in non-cavitated carious lesions); the caries may affect any single tooth…

The review found no eligible studies for this question.

1 finding from 1 review

Ozone therapy for the treatment of dental caries 2004 · Cochrane All outcomes
No data were provided in any of the included trials on pain.
Studies not reported
No studies found

Ozone applied to the carious lesion (10 or 40 seconds), with a fluoride reductant and oral hygiene/preventive advice vs No ozone, with a fluoride reductant and oral hygiene/preventive advice (as in the intervention group)

Caries progression/regression (clinical severity index, log(e) ECM and log(e) DIAGNOdent scores) · People of any age with caries (including demineralisation in non-cavitated carious lesions); the caries may affect any single tooth…

1 finding from 1 review

Ozone therapy for the treatment of dental caries 2004 · Cochrane All outcomes
6 and 12 months
No consistent trend of benefit or harm following ozone was seen across the outcome measures in any of the three studies; analyses were conducted at the lesion level (not independent of the person), so data were not…
3 studies · 137 participants
GRADE not reported

Any anti‐osteoporotic drugs vs placebo

Vertebral fracture by radiography · postmenopausal women with osteoporosis and CKD stages 3‐4

Any anti‐osteoporotic drugs may leads to lower vertebral fracture by radiography compared with placebo (low certainty).

1 finding from 1 review

Pharmacological interventions versus placebo, no treatment or usual care for osteoporosis in people with chronic… 2021 · Cochrane Headline outcomes only
RR 0.52 [0.39, 0.69]
5 studies · 9054 participants
Low