Cochrane · systematic review · CD009666
Point‐of‐use fortification of foods with micronutrient powders containing iron in children of preschool and school‐age
De‐Regil, LM, Jefferds, MED, Peña‐Rosas, JP · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
Developmental, Psychosocial and Learning ProblemsAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 14.3%Low 3 · 42.9%Moderate 3 · 42.9%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Point‐of‐use fortification of foods with micronutrients powders (MNP) compared to no intervention or placebo in preschool and school‐age children
Population: preschool and school‐age children
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Anaemia (defined as haemoglobin < 110 g/L for children aged 24‐59 months and < 115 g/L for children aged 5‐11.9 years, adjusted by altitude where appropriate)* Point‐of‐use fortification of foods with micronutrients powders (MNP) vs no intervention or placebo | RR 0.66 [0.49, 0.88] | 10 studies · 2448 participants | Moderate Downgraded: risk of bias, inconsistency |
Haemoglobin Point‐of‐use fortification of foods with micronutrients powders (MNP) vs no intervention or placebo | no estimate extracted | 11 studies · 2746 participants | Low Downgraded: risk of bias, inconsistency |
Iron deficiency (defined by using ferritin concentrations less than 15 µg/L) Point‐of‐use fortification of foods with micronutrients powders (MNP) vs no intervention or placebo | RR 0.35 [0.27, 0.47] | 5 studies · 1364 participants | Moderate Downgraded: risk of bias, inconsistency |
Ferritin Point‐of‐use fortification of foods with micronutrients powders (MNP) vs no intervention or placebo | no estimate extracted | 3 studies · 1066 participants | Very low Downgraded: risk of bias, inconsistency |
All‐cause mortality (number of deaths during trial) Point‐of‐use fortification of foods with micronutrients powders (MNP) vs no intervention or placebo | no estimate extracted | 1 study · 115 participants | Low |
Diarrhoea (≥ 3 liquid stools per day) Point‐of‐use fortification of foods with micronutrients powders (MNP) vs no intervention or placebo | RR 0.97 [0.53, 1.78] | 2 studies · 366 participants | Low Downgraded: inconsistency |
Adverse effects (any, as defined by trialists) Point‐of‐use fortification of foods with micronutrients powders (MNP) vs no intervention or placebo | RR 1.09 [0.16, 7.42] | 1 study · 90 participants | Moderate Downgraded: risk of bias, inconsistency |