Question · asked by 1 review
SSRIs or SNRIs vs amitriptyline: Participants who withdraw because of an adverse event or any other reason
- Population
- patients for whom migraine preventive interventions are indicated
- Intervention
- SSRIs or SNRIs
- Comparison
- amitriptyline
- Outcome
- Participants who withdraw because of an adverse event or any other reason
SSRIs or SNRIs showed no clear difference in withdrawn (for any reasons and due to adverse events) compared with amitriptyline (low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
SSRIs or SNRIs vs amitriptyline Withdrawn (for any reasons and due to adverse events) · patients for whom migraine preventive interventions are indicated SSRIs or SNRIs showed no clear difference in withdrawn (for any reasons and due to adverse events) compared with amitriptyline (low certainty). Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for… (2015) · Cochrane Headline outcomes only | OR 0.39 [0.1, 1.5] | 1 study · 64 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the prevention of migraine in… 2015 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.