Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

44 questions · 50 findings · 20 reviews · Drugs and Alcohol

No studies found 1 · 2%GRADE not reported 1 · 2%Very low 12 · 24%Low 20 · 40%Moderate 15 · 30%High 1 · 2%

Motivational interviewing vs treatment

Over 50% less standard drinks per day Timeline follow back · concurrent problem alcohol and illicit drug users

Motivational interviewing (MI) showed no clear difference in greater than 50% reduction in number of standard drinks consumed per… compared with treatment (low certainty).

1 finding from 1 review

Motivational interviewing vs treatment

Abstinence from alcohol over the last 30 days · concurrent problem alcohol and illicit drug users

Motivational interviewing (MI) showed no clear difference in abstinence from alcohol over the last 30 days compared with treatment (low certainty).

1 finding from 1 review

Brief motivational interviewing (BMI) vs assessment‐only to reduce alcohol consumption

25% reduction of drinking days in the past 30 days · concurrent problem alcohol and illicit drug users

Brief motivational interviewing (BMI) showed no clear difference in 25% reduction of drinking days in the past 30 days compared with assessment‐only to reduce alcohol consumption (moderate certainty).

1 finding from 1 review

Brief motivational interviewing (BMI) vs assessment‐only to reduce alcohol consumption

50% reduction of drinking days in the past 30 days · concurrent problem alcohol and illicit drug users

Brief motivational interviewing (BMI) showed no clear difference in 50% reduction of drinking days in the past 30 days compared with assessment‐only to reduce alcohol consumption (moderate certainty).

1 finding from 1 review

Brief motivational interviewing (BMI) vs assessment‐only to reduce alcohol consumption

or more drinking days' reduction in the past 30 days · concurrent problem alcohol and illicit drug users

Brief motivational interviewing (BMI) probably leads to higher or more drinking days' reduction in the past 30 days compared with assessment‐only to reduce alcohol consumption (moderate certainty).

1 finding from 1 review

Buprenorphine vs alpha2‐adrenergic agonists

Mean days in treatment (with varying scheduled duration) · Adults or adolescents with opioid dependence

Buprenorphine probably leads to higher mean days in treatment (with varying scheduled duration) compared with alpha2‐adrenergic agonists (moderate certainty).

1 finding from 1 review

Intervention not reported

Cannabis use quantity per day at short‐term · adults with cannabis use disorder or frequent cannabis use

It is very uncertain whether the intervention changes cannabis use quantity per day at short‐term (very low certainty).

1 finding from 1 review

Antipsychotics vs placebo

Number of participants using cocaine during the treatment (as days/week by urine tests or self report) Number of participants that reported the use of cocaine during the treatment · patients with the treatment of cocaine dependence

Any antipsychotic showed no clear difference in number of participants using cocaine during the treatment (as… compared with placebo (low certainty).

1 finding from 1 review