Cochrane · systematic review · CD006306
Antipsychotic medications for cocaine dependence
Indave, BI, Minozzi, S, Pani, PP, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
Drugs and AlcoholAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
5
current version
GRADE rated
5
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 4 · 80%Moderate 1 · 20%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Any antipsychotic versus placebo for cocaine dependence (Update)
Population: people with cocaine dependence
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Dropouts Number of participants who dropped out from the study Any antipsychotic vs placebo | RR 0.75 [0.57, 0.97] | 8 studies · 397 participants | Moderate Downgraded: risk of bias |
Side effects Number of participants with at least i side effect Any antipsychotic vs placebo | RR 1.01 [0.93, 1.1] | 6 studies · 291 participants | Low Downgraded: risk of bias, imprecision |
Number of participants using cocaine during the treatment (as days/week by urine tests or self report) Number of participants that reported the use of cocaine during the treatment Any antipsychotic vs placebo | RR 1.02 [0.65, 1.62] | 2 studies · 91 participants | Low Downgraded: risk of bias, imprecision |
Continuous abstinence (number of participants who maintained negative drug screens for 2 ‐ 3 weeks) Number of participants that maintained negative cocaine screens for at least 2 ‐ 3 weeks Any antipsychotic vs placebo | RR 1.3 [0.73, 2.32] | 3 studies · 139 participants | Low Downgraded: risk of bias |
Craving (Brief Substance Craving Scale) Brief Substance Craving Scale. Scale from: 0 to 4. Any antipsychotic vs placebo | no estimate extracted | 4 studies · 240 participants | Low Downgraded: risk of bias, imprecision, inconsistency |