Cochrane · systematic review · CD008544
Anticonvulsants for alcohol dependence
Pani, PP, Trogu, E, Pacini, M, et al. · Cochrane Database of Systematic Reviews · 2014 · Cochrane Library
Drugs and AlcoholAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
5
current version
GRADE rated
5
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 5 · 100%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Anticonvulsants versus placebo for alcohol dependence
Population: patients with alcohol dependence
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Dropouts Anticonvulsants vs placebo | RR 0.94 [0.74, 1.19] | 16 studies · 1675 participants | Moderate Downgraded: inconsistency |
Continuous abstinence Anticonvulsants vs placebo | RR 1.21 [0.97, 1.52] | 634 participants | Moderate |
Drinks/drinking day Anticonvulsants vs placebo | no estimate extracted | 11 studies · 1126 participants | Moderate Downgraded: risk of bias |
Heavy drinking Anticonvulsants vs placebo | no estimate extracted | 12 studies · 1129 participants | Moderate Downgraded: risk of bias |
Adverse events—withdrawn for medical reasons Anticonvulsants vs placebo | RR 1.22 [0.58, 2.56] | 12 studies · 1410 participants | Moderate Downgraded: inconsistency |