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Evidence found and GRADE certainty

119 questions · 121 findings · 22 reviews · Headline outcomes only

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No studies found 12 · 9.9%GRADE not reported 7 · 5.8%Very low 36 · 29.8%Low 43 · 35.5%Moderate 19 · 15.7%High 4 · 3.3%

10 mg warfarin nomogram vs 5 mg warfarin nomogram

Major bleeding fall in hemoglobin of > 20 g/L or transfusion of 2 or more units of red cells · patients with venous thromboembolism.

10 mg warfarin nomogram showed no clear difference in major bleeding fall in hemoglobin of > 20 g/L or transfusion of 2 or… compared with 5 mg warfarin nomogram (moderate certainty).

1 finding from 1 review

Intervention not reported

HIV incidence: CD4 subgroups (<200 cells/µL) (observational studies) · Serodiscordant couples

The intervention may leads to lower HIV incidence: CD4 subgroups (<200 cells/µL) (observational studies) (low certainty).

1 finding from 1 review

Intervention not reported

HIV incidence: CD4 subgroups (200‐350 CD4 cells/µL) (observational studies) · Serodiscordant couples

It is very uncertain whether the intervention changes HIV incidence: CD4 subgroups (200‐350 CD4 cells/µL) (observational… (very low certainty).

1 finding from 1 review

Intervention not reported

HIV incidence: CD4 subgroups (350 or more CD4 cells/µL) (observational studies) · Serodiscordant couples

The intervention may leads to lower HIV incidence: CD4 subgroups (350 or more CD4 cells/µL)… (low certainty).

1 finding from 1 review

Intervention not reported

Virologically linked HIV incidence: CD4 subgroups (350 or more CD4 cells/µL) (RCT) · Serodiscordant couples

The intervention leads to lower virologically linked HIV incidence: CD4 subgroups (350 or more CD4… (high certainty).

1 finding from 1 review

Intervention not reported

All‐cause mortality · ≥ 15‐year‐old people with late second stage human African gambiense trypanosomiasis (trypanosomes in blood or nymph node fluid and WBC >…

The intervention showed no clear difference in all‐cause mortality (low certainty).

1 finding from 1 review

Intervention not reported

Relapsec · ≥ 15‐year‐old people with late second stage human African gambiense trypanosomiasis (trypanosomes in blood or nymph node fluid and WBC >…

The intervention probably leads to higher relapsec (moderate certainty).

1 finding from 1 review

Intervention not reported

Serious adverse events · ≥ 15‐year‐old people with late second stage human African gambiense trypanosomiasis (trypanosomes in blood or nymph node fluid and WBC >…

It is very uncertain whether the intervention changes serious adverse events (very low certainty).

1 finding from 1 review

Intervention not reported

Adverse events · ≥ 15‐year‐old people with late second stage human African gambiense trypanosomiasis (trypanosomes in blood or nymph node fluid and WBC >…

The intervention showed no clear difference in adverse events (moderate certainty).

1 finding from 1 review

Early ART vs standard or deferred ART (CD4 <= 200 or CD4 <= 250 cells/µl)

Death · patients with asymptomatic, HIV‐infected, treatment naive adults

Early ART probably leads to lower death compared with standard or deferred ART (CD4 <= 200 or CD4 <= 250 cells/µl) (moderate certainty).

1 finding from 1 review

Early ART vs standard or deferred ART (CD4 <= 200 or CD4 <= 250 cells/µl)

Tuberculosis · patients with asymptomatic, HIV‐infected, treatment naive adults

Early ART showed no clear difference in tuberculosis compared with standard or deferred ART (CD4 <= 200 or CD4 <= 250 cells/µl) (moderate certainty).

1 finding from 1 review

Early ART vs standard or deferred ART (CD4 <= 200 or CD4 <= 250 cells/µl)

Disease progression measured by opportunistic disease Opportunistic disease events · patients with asymptomatic, HIV‐infected, treatment naive adults

Early ART showed no clear difference in disease progression measured by opportunistic disease Opportunistic… compared with standard or deferred ART (CD4 <= 200 or CD4 <= 250 cells/µl) (low certainty).

1 finding from 1 review

Kesho Bora: AZT/3TC/LPV‐r vs Short‐Course AZT (intrapartum AZT/3TC/sd‐NVP)

Infant HIV Transmission or Death at 6 Months · HIV‐infected Pregnant Women With CD4 Counts 200‐500 Cells/mm3

Kesho Bora: AZT/3TC/LPV‐r showed no clear difference in infant HIV Transmission or Death at 6 Months compared with short‐Course AZT (intrapartum AZT/3TC/sd‐NVP) (low certainty).

1 finding from 1 review