Cochrane · systematic review · CD011577
Comparison of a restrictive versus liberal red cell transfusion policy for patients with myelodysplasia, aplastic anaemia, and other congenital bone marrow failure disorders
Gu, Y, Estcourt, LJ, Doree, C, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
HaematologyAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
2
No studies
5
Included studies
NR
No studies 5 · 71.4%Ungraded 0 · 0%Very low 2 · 28.6%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Comparison
Population: patients with myelodysplastic syndrome
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All cause mortality | RR 0.13 [0.01, 2.32] | 1 study · 13 participants | Very low Downgraded: imprecision |
Mortality secondary to bleeding/infection/transfusion reactions or iron overload ‐ not reported | no estimate extracted | NR | No studies |
Quality of life ‐ not reported | no estimate extracted | NR | No studies |
Frequency and length of hospital admissions ‐ not reported | no estimate extracted | NR | No studies |
Serious infections (requiring admission to hospital) ‐ not reported | no estimate extracted | NR | No studies |
Serious bleeding (e.g. WHO/CTCAE grade 3 (or equivalent) or above ) ‐ not reported | no estimate extracted | NR | No studies |
Red blood cell transfusion requirements (units of red blood cells per patient per month) | no estimate extracted | 1 study · 13 participants | Very low Downgraded: imprecision |