Early ART vs standard or deferred ART (CD4 <= 200 or CD4 <= 250 cells/µl): Death
- Population
- patients with asymptomatic, HIV‐infected, treatment naive adults
- Intervention
- Early ART
- Comparison
- standard or deferred ART (CD4 <= 200 or CD4 <= 250 cells/µl)
- Outcome
- Death
Early ART probably leads to lower death compared with standard or deferred ART (CD4 <= 200 or CD4 <= 250 cells/µl) (moderate certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Early ART vs standard or deferred ART (CD4 <= 200 or CD4 <= 250 cells/µl) Death · patients with asymptomatic, HIV‐infected, treatment naive adults Early ART probably leads to lower death compared with standard or deferred ART (CD4 <= 200 or CD4 <= 250 cells/µl) (moderate certainty). Optimal time for initiation of antiretroviral therapy in asymptomatic, HIV‐infected, treatment‐naive adults (2010) · Cochrane Headline outcomes only | RR 0.26 [0.11, 0.62] | 2 studies · 1065 participants | Moderate |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Optimal time for initiation of antiretroviral therapy in asymptomatic, HIV‐infected, treatment‐naive adults 2010 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
- Early ART vs delayed ART initiation · patients with antiretroviral therapy initiation in patients with HIV infection and… · 0 reviews
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.