Cochrane · systematic review · CD008272
Optimal time for initiation of antiretroviral therapy in asymptomatic, HIV‐infected, treatment‐naive adults
Siegfried, N, Uthman, OA, Rutherford, GW · Cochrane Database of Systematic Reviews · 2010 · Cochrane Library
HIV/AIDSAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
3
current version
GRADE rated
3
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 1 · 33.3%Moderate 2 · 66.7%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Early ART versus standard or deferred ART (CD4 <= 200 or CD4 <= 250 cells/µl) for asymptomatic, HIV‐infected, treatment naive adults
Population: patients with asymptomatic, HIV‐infected, treatment naive adults
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death Early ART vs standard or deferred ART (CD4 <= 200 or CD4 <= 250 cells/µl) | RR 0.26 [0.11, 0.62] | 2 studies · 1065 participants | Moderate Downgraded: publication bias |
Tuberculosis Early ART vs standard or deferred ART (CD4 <= 200 or CD4 <= 250 cells/µl) | RR 0.54 [0.26, 1.12] | 2 studies · 1065 participants | Moderate Downgraded: publication bias |
Disease progression measured by opportunistic disease Opportunistic disease events Early ART vs standard or deferred ART (CD4 <= 200 or CD4 <= 250 cells/µl) | OR 0.29 [0.03, 2.87] | 1 study · 249 participants | Low Downgraded: indirectness, publication bias |