Early ART vs standard or deferred ART (CD4 <= 200 or CD4 <= 250 cells/µl): Disease progression measured by opportunistic disease Opportunistic disease events
Early ART showed no clear difference in disease progression measured by opportunistic disease Opportunistic… compared with standard or deferred ART (CD4 <= 200 or CD4 <= 250 cells/µl) (low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Early ART vs standard or deferred ART (CD4 <= 200 or CD4 <= 250 cells/µl) Disease progression measured by opportunistic disease Opportunistic disease events · patients with asymptomatic, HIV‐infected, treatment naive adults Early ART showed no clear difference in disease progression measured by opportunistic disease Opportunistic… compared with standard or deferred ART (CD4 <= 200 or CD4 <= 250 cells/µl) (low certainty). Optimal time for initiation of antiretroviral therapy in asymptomatic, HIV‐infected, treatment‐naive adults (2010) · Cochrane Headline outcomes only | OR 0.29 [0.03, 2.87] | 1 study · 249 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Optimal time for initiation of antiretroviral therapy in asymptomatic, HIV‐infected, treatment‐naive adults 2010 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.