Cochrane · systematic review · CD003650
Micronutrient supplementation in adults with HIV infection
Visser, ME, Durao, S, Sinclair, D, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
Infectious DiseasesAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
25
current version
GRADE rated
21
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 4 · 16%Very low 7 · 28%Low 11 · 44%Moderate 3 · 12%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Multiple micronutrients compared to placebo for adults with HIV infection
Population: adults with HIV infection (with and without concurrent tuberculosis, with and without ART)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality Multiple micronutrients vs placebo | RR 0.91 [0.72, 1.15] | 7 studies · 2897 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Hospital admissions Multiple micronutrients vs placebo | RR 0.86 [0.61, 1.22] | 2 studies · 881 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
CD4 cell count Multiple micronutrients vs placebo | no estimate extracted | 6 studies · 1581 participants | Low Downgraded: risk of bias, inconsistency, indirectness |
Viral load Multiple micronutrients vs placebo | no estimate extracted | 4 studies · 840 participants | Moderate Downgraded: risk of bias, indirectness |
Nutritional status Multiple micronutrients vs placebo | no estimate extracted | 3 studies · 1007 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Vitamin A compared to placebo
Population: adults with HIV infection
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality Vitamin A vs placebo | no estimate extracted | 0 studies · 0 participants | Ungraded |
Morbidity Vitamin A vs placebo | no estimate extracted | 0 studies · 0 participants | Ungraded |
CD4 cell count (cells/mm³) Vitamin A vs placebo | no estimate extracted | 2 studies · 464 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Viral load (log10copies/mL) Vitamin A vs placebo | no estimate extracted | 3 studies · 495 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Change in vitamin A concentrations (µmol/L) Vitamin A vs placebo | no estimate extracted | 3 studies · 495 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Vitamin D compared to placebo
Population: adults with HIV infection
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality Vitamin D vs placebo | RR 1.15 [0.65, 2.02] | 1 study · 131 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Morbidity Vitamin D vs placebo | no estimate extracted | 0 studies · 0 participants | Ungraded |
CD4 cell count (cells/mm³) Vitamin D vs placebo | no estimate extracted | 4 studies · 288 participants | Low Downgraded: risk of bias, indirectness |
Viral load (log10copies/mL) Vitamin D vs placebo | no estimate extracted | 1 study · 28 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Change in 25(OH) vitamin D concentrations (ng/mL) Vitamin D vs placebo | no estimate extracted | 4 studies · 299 participants | Moderate Downgraded: risk of bias, inconsistency, indirectness |
Zinc compared to placebo
Population: adults with HIV infection
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality Zinc vs placebo | RR 1.24 [0.53, 2.86] | 3 studies · 433 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Rate of diarrhoea Zinc vs placebo | OR 0.4 [0.18, 0.87] | 1 study · 231 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Change in CD4 cell count (cells/mm³) Zinc vs placebo | no estimate extracted | 4 studies · 431 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Change in viral load (log10copies/mL) Zinc vs placebo | no estimate extracted | 3 studies · 400 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Change in blood zinc concentrations Zinc vs placebo | no estimate extracted | 4 studies · 484 participants | Moderate Downgraded: risk of bias, inconsistency, indirectness |
Selenium compared to placebo
Population: adults with HIV infection
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality Selenium vs placebo | no estimate extracted | 0 studies · 0 participants | Ungraded |
Hospital admissions Selenium vs placebo | RR 0.4 [0.21, 0.75] | 1 study · 186 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Change in CD4 cell count (cells/mm³) Selenium vs placebo | no estimate extracted | 4 studies · 1187 participants | Low Downgraded: risk of bias, imprecision |
Change in viral load (log10copies/mL) Selenium vs placebo | no estimate extracted | 1 study · 439 participants | Low Downgraded: risk of bias, indirectness |
Change in selenium concentrations (µg/L) Selenium vs placebo | no estimate extracted | 3 studies · 527 participants | Low Downgraded: risk of bias, inconsistency, indirectness |