Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

136 questions · 139 findings · 26 reviews

No studies found 12 · 8.6%GRADE not reported 25 · 18%Very low 36 · 25.9%Low 43 · 30.9%Moderate 19 · 13.7%High 4 · 2.9%

Antifibrinolytic therapy - locally-applied tranexamic acid (TXA) mouthwash/solution (SoF eligibility: TXA or EACA; all included trials used topical TXA) vs standard local care

Major bleeding, requiring transfusion of packed red blood cells · People on continuous VKA treatment undergoing minor oral surgery or dental extractions (eligibility included DOACs and all ages; all four…

Antifibrinolytic therapy - locally-applied tranexamic acid (TXA)… showed no clear difference in major bleeding requiring transfusion of packed red blood cells compared with standard care (usual local haemostatic measures: gelatin sponge and…; GRADE not reported.

1 finding from 1 review

Antifibrinolytic therapy - locally-applied tranexamic acid (TXA) mouthwash/solution (SoF eligibility: TXA or EACA; all included trials used topical TXA) vs Placebo mouthwash

Major bleeding, requiring transfusion of packed red blood cells · People on continuous VKA treatment undergoing minor oral surgery or dental extractions (eligibility included DOACs and all ages; all four…

Antifibrinolytic therapy - locally-applied tranexamic acid (TXA)… showed no clear difference in major bleeding requiring transfusion of packed red blood cells compared with placebo (placebo solution/mouthwash); GRADE not reported.

1 finding from 1 review

10 mg warfarin nomogram vs 5 mg warfarin nomogram

Major bleeding fall in hemoglobin of > 20 g/L or transfusion of 2 or more units of red cells · patients with venous thromboembolism.

10 mg warfarin nomogram showed no clear difference in major bleeding fall in hemoglobin of > 20 g/L or transfusion of 2 or… compared with 5 mg warfarin nomogram (moderate certainty).

1 finding from 1 review

Intervention not reported

HIV incidence: CD4 subgroups (<200 cells/µL) (observational studies) · Serodiscordant couples

The intervention may leads to lower HIV incidence: CD4 subgroups (<200 cells/µL) (observational studies) (low certainty).

1 finding from 1 review

Intervention not reported

HIV incidence: CD4 subgroups (200‐350 CD4 cells/µL) (observational studies) · Serodiscordant couples

It is very uncertain whether the intervention changes HIV incidence: CD4 subgroups (200‐350 CD4 cells/µL) (observational… (very low certainty).

1 finding from 1 review

Intervention not reported

HIV incidence: CD4 subgroups (350 or more CD4 cells/µL) (observational studies) · Serodiscordant couples

The intervention may leads to lower HIV incidence: CD4 subgroups (350 or more CD4 cells/µL)… (low certainty).

1 finding from 1 review

Intervention not reported

Virologically linked HIV incidence: CD4 subgroups (350 or more CD4 cells/µL) (RCT) · Serodiscordant couples

The intervention leads to lower virologically linked HIV incidence: CD4 subgroups (350 or more CD4… (high certainty).

1 finding from 1 review

Intervention not reported

All‐cause mortality · ≥ 15‐year‐old people with late second stage human African gambiense trypanosomiasis (trypanosomes in blood or nymph node fluid and WBC >…

The intervention showed no clear difference in all‐cause mortality (low certainty).

1 finding from 1 review

Intervention not reported

Relapsec · ≥ 15‐year‐old people with late second stage human African gambiense trypanosomiasis (trypanosomes in blood or nymph node fluid and WBC >…

The intervention probably leads to higher relapsec (moderate certainty).

1 finding from 1 review

Intervention not reported

Serious adverse events · ≥ 15‐year‐old people with late second stage human African gambiense trypanosomiasis (trypanosomes in blood or nymph node fluid and WBC >…

It is very uncertain whether the intervention changes serious adverse events (very low certainty).

1 finding from 1 review