Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

954 questions · 963 findings · 130 reviews · Headline outcomes only

No studies found 181 · 18.8%GRADE not reported 71 · 7.4%Very low 163 · 16.9%Low 311 · 32.3%Moderate 163 · 16.9%High 74 · 7.7%

Ondansetron vs promethazine

Severity, reduction or cessation in nausea/vomiting 2. Number of episodes of emesis 3. Quality of life outcomes 4. Pregnancy complications 5. Adverse fetal/neonatal outcomes · Pregnant women with hyperemesis gravidarum

The review found no eligible studies for this question.

1 finding from 1 review

Therapeutic swallowing exercises vs treatment

Swallowing function/efficiency Measured using a rating of oropharyngeal swallowing efficiency (OPSE) quantifying the interaction of the speed of bolus movement and safety/efficiency in clearing material from the oropharynx Dysphagia is defined as ... · adults with advanced head and neck cancer

It is very uncertain whether therapeutic swallowing exercises changes swallowing function/efficiency Measured using a rating of… compared with treatment (very low certainty).

1 finding from 1 review

Regional analgesia (with tocolysis) vs no intervention of regional analgesia (with or without tocolysis)

Fetal bradycardia (primary) · patients with breech presentation

Regional analgesia (with tocolysis) showed no clear difference in fetal bradycardia (primary) compared with no intervention of regional analgesia (with or without tocolysis) (low certainty).

1 finding from 1 review

Vitamin E vs placebo, no placebo or other supplements

Preterm prelabour rupture of membranes · pregnant women receiving vitamin E supplementation or control, living in areas where there is either inadequate dietary intake of vitamin…

Any vitamin E supplementation showed no clear difference in prelabour rupture of fetal membranes ‐ preterm compared with placebo, no placebo or other supplements (low certainty).

1 finding from 1 review

Lidocaine vs pirmenol

Adverse events (any type) and safety of sealant · patients with myocardial infarction

It is very uncertain whether lidocaine changes safety (AEs; adverse drug reaction): any adverse event compared with pirmenol (very low certainty).

1 finding from 1 review

Planned early birth vs expectant management

Perinatal mortality (stillbirth ‐ death of fetus prior to birth; neonatal death ‐ death within the first 28 days of birth; or infant death ‐ death after the first 28 days) · pregnant women with a term suspected compromised baby
1 finding from 1 review

Ruxolitinib vs best available therapy

Safety (AE, adverse drug reaction): thrombocytopenia Grades 3 or 4 according to National Cancer Institute · Patients with treating MF

Ruxolitinib showed no clear difference in safety (AE, adverse drug reaction): thrombocytopenia Grades 3 or 4… compared with best available therapy (low certainty).

1 finding from 1 review

Ruxolitinib vs placebo

Safety (AE, adverse drug reaction): thrombocytopenia Grades 3 or 4 according to National Cancer Institute · Patients with treating MF

Ruxolitinib may leads to higher safety (AE, adverse drug reaction): thrombocytopenia Grades 3 or 4… compared with placebo (low certainty).

1 finding from 1 review

Ruxolitinib vs best available therapy

Safety (AE, adverse drug reaction): anemia Grades 3 or 4 according to National Cancer Institute · Patients with treating MF

Ruxolitinib showed no clear difference in safety (AE, adverse drug reaction): anemia Grades 3 or 4 according… compared with best available therapy (low certainty).

1 finding from 1 review

hCG vs no ovulation trigger

Live birth rate Live fetus delivered beyond 20 completed weeks' gestation · women with anovulatory infertility undergoing ovulation induction with clomiphene citrate

Human chorionic gonadotrophin showed no clear difference in live birth rate Live fetus delivered beyond 20 completed weeks'… compared with no ovulation trigger (low certainty).

1 finding from 1 review