Cochrane · systematic review · CD011263
Screening and subsequent management for thyroid dysfunction pre‐pregnancy and during pregnancy for improving maternal and infant health
Spencer, L, Bubner, T, Bain, E, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
Pregnancy and ChildbirthAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
16
current version
GRADE rated
8
No studies
8
Included studies
NR
No studies 8 · 50%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 5 · 31.3%High 3 · 18.8%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Universal screening versus case finding in pregnancy for any thyroid dysfunction
Population: women during pregnancy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Thyroid dysfunction diagnosed in pregnancy: hypothyroid Universal screening vs case finding | RR 3.15 [1.91, 5.2] | 1 study · 4562 participants | High |
Thyroid dysfunction diagnosed in pregnancy: hyperthyroid Universal screening vs case finding | RR 4.5 [0.97, 20.82] | 1 study · 4562 participants | Moderate Downgraded: imprecision |
Pre‐eclampsia Universal screening vs case finding | RR 0.87 [0.64, 1.18] | 1 study · 4516 participants | Moderate Downgraded: imprecision |
Neurosensory disability (any of cerebral palsy, blindness, deafness, developmental delay/intellectual impairment, at latest time reported): IQ < 85 at 3 years of age Universal screening vs case finding | no estimate extracted | NR | No studies |
Preterm birth Universal screening vs case finding | RR 0.99 [0.8, 1.24] | 1 study · 4516 participants | High |
Miscarriage Universal screening vs case finding | RR 0.9 [0.68, 1.19] | 1 study · 4516 participants | Moderate Downgraded: imprecision |
Adverse effects associated with the intervention Universal screening vs case finding | no estimate extracted | NR | No studies |
Fetal and neonatal death Universal screening vs case finding | RR 0.92 [0.42, 2.02] | 1 study · 4516 participants | Moderate Downgraded: imprecision |
Universal screening versus no screening in pregnancy for hypothyroidism
Population: women during pregnancy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Thyroid dysfunction diagnosed in pregnancy: hypothyroid Universal screening vs no screening | RR 998.18 [62.36, 15978.48] | 1 study · 21839 participants | High |
Thyroid dysfunction diagnosed in pregnancy: hyperthyroid Universal screening vs no screening | no estimate extracted | NR | No studies |
Pre‐eclampsia Universal screening vs no screening | no estimate extracted | NR | No studies |
Preterm birth Universal screening vs no screening | no estimate extracted | NR | No studies |
Neurosensory disability (any of cerebral palsy, blindness, deafness, developmental delay/intellectual impairment, at latest time reported): IQ < 85 at 3 years of age Universal screening vs no screening | RR 0.85 [0.6, 1.22] | 1 study · 794 participants | Moderate Downgraded: imprecision |
Miscarriage Universal screening vs no screening | no estimate extracted | NR | No studies |
Adverse effects associated with the intervention Universal screening vs no screening | no estimate extracted | NR | No studies |
Death (defined as all fetal and neonatal deaths) Universal screening vs no screening | no estimate extracted | NR | No studies |