Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,005 questions · 1,053 findings · 151 reviews · Headline outcomes only

No studies found 275 · 26.1%GRADE not reported 150 · 14.2%Very low 271 · 25.7%Low 215 · 20.4%Moderate 105 · 10%High 37 · 3.5%

Telerehabilitation vs self‐training

Technical difficulties · people with any eye disease including optic nerve disease, age‐related macular degeneration, retinopathy of prematurity, retinitis…

It is very uncertain whether telerehabilitation changes technical difficulties with the intervention at 6 months compared with self‐training (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Exercise plus usual pharmacological care vs another intervention (education, joint aids, or relaxation) plus usual pharmacological care

Withdrawals due to any reason · systemic lupus erythematosus

It is very uncertain whether summary of findings table ‐ Exercise plus usual pharmacological care changes withdrawals due to any reason compared with another intervention (education, joint aids, or relaxation) plus… (very low certainty).

1 finding from 1 review

Antidepressants vs any other pharmacological intervention

Depression remission · women of any age, with PND up to 12 months

It is very uncertain whether antidepressants changes depression remission (acute phase, 5 ≤ 12 weeks) compared with any other pharmacological intervention (very low certainty).

2 findings from 1 review

Probiotics administered exclusively after birth in mothers of preterm infants vs placebo or no intervention

Necrotising enterocolitis · preterm infants

Probiotics administered exclusively after birth in mothers of… showed no clear difference in any necrotizing Enterocolitis (NEC) compared with maternal placebo or no intervention (low certainty).

1 finding from 1 review

Home (point‐of‐use) fortification of foods with multiple micronutrient powders vs placebo or no intervention

Any adverse effects (e.g. hypervitaminosis A, as defined by the trialists) · preschool and school‐age children

Point‐of‐use fortification of foods with micronutrients powders (MNP) showed no clear difference in adverse effects (any, as defined by trialists) compared with no intervention or placebo (moderate certainty).

1 finding from 1 review

Thromboelastography (TEG) or thromboelastometry (ROTEM) vs any comparison

Rate of surgical reintervention · adults or children with bleeding

Thromboelastography (TEG) or thromboelastometry (ROTEM) showed no clear difference in rate of surgical reintervention compared with any comparison (low certainty).

1 finding from 1 review

SSRIs or SNRIs vs amitriptyline

Participants who withdraw because of an adverse event or any other reason · patients for whom migraine preventive interventions are indicated

SSRIs or SNRIs showed no clear difference in withdrawn (for any reasons and due to adverse events) compared with amitriptyline (low certainty).

1 finding from 1 review

Technology‐mediated psychoeducation vs usual care

Leaving the study early · schizophrenia

It is very uncertain whether technology‐mediated psychoeducation changes compliance/satisfaction: leaving the study early ‐ any reason compared with standard care intervention (very low certainty).

1 finding from 1 review