Cochrane · systematic review · CD014816
Exercise as adjunctive therapy for systemic lupus erythematosus
Frade, S, O'Neill, S, Greene, D, et al. · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library
MusculoskeletalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
21
current version
GRADE rated
14
No studies
7
Included studies
NR
No studies 7 · 33.3%Ungraded 0 · 0%Very low 4 · 19%Low 9 · 42.9%Moderate 1 · 4.8%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Summary of findings table ‐ Exercise plus usual pharmacological care compared to placebo plus usual pharmacological care for systemic lupus erythematosus
Population: systemic lupus erythematosus
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Fatigue (FACIT‐Fatigue, score 0‐52, lower scores indicate less fatigue) Summary of findings table ‐ Exercise plus usual pharmacological care vs placebo plus usual pharmacological care | no estimate extracted | 1 study · 17 participants | Low Downgraded: risk of bias, imprecision |
Functional capacity (SF‐36 Function Capacity domain, score 0‐100, higher scores indicate better functional capacity) Summary of findings table ‐ Exercise plus usual pharmacological care vs placebo plus usual pharmacological care | no estimate extracted | 1 study · 17 participants | Low Downgraded: risk of bias, imprecision |
Pain (SF‐36 Pain domain, score 0‐100, lower scores indicate less pain) Summary of findings table ‐ Exercise plus usual pharmacological care vs placebo plus usual pharmacological care | no estimate extracted | 1 study · 17 participants | Low Downgraded: risk of bias, imprecision |
Disease activity ‐ not measured Summary of findings table ‐ Exercise plus usual pharmacological care vs placebo plus usual pharmacological care | no estimate extracted | NR | No studies |
Quality of life ‐ not measured Summary of findings table ‐ Exercise plus usual pharmacological care vs placebo plus usual pharmacological care | no estimate extracted | NR | No studies |
Serious adverse events ‐ not reported Summary of findings table ‐ Exercise plus usual pharmacological care vs placebo plus usual pharmacological care | no estimate extracted | NR | No studies |
Withdrawals due to any reason Summary of findings table ‐ Exercise plus usual pharmacological care vs placebo plus usual pharmacological care | RR 2.73 [0.34, 22.16] | 1 study · 21 participants | Very low Downgraded: risk of bias, imprecision |
Summary of findings table ‐ Exercise plus usual pharmacological care compared to usual pharmacological care alone for systemic lupus erythematosus
Population: systemic lupus erythematosus
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Fatigue (Fatigue Severity Scale, score 1‐7, lower score indicates less fatigue) Summary of findings table ‐ Exercise plus usual pharmacological care vs usual pharmacological care alone | no estimate extracted | 2 studies · 104 participants | Low Downgraded: risk of bias |
Functional capacity (SF‐36 Physical Function domain, score 0‐100, higher scores indicate better functional capacity) Summary of findings table ‐ Exercise plus usual pharmacological care vs usual pharmacological care alone | no estimate extracted | 2 studies · 96 participants | Low Downgraded: risk of bias |
Disease activity (SLEDAI scale, scores 0‐105, lower scores indicate less disease activity) Summary of findings table ‐ Exercise plus usual pharmacological care vs usual pharmacological care alone | no estimate extracted | 2 studies · 100 participants | Low Downgraded: risk of bias |
Quality of life ‐ not reported Summary of findings table ‐ Exercise plus usual pharmacological care vs usual pharmacological care alone | no estimate extracted | NR | No studies |
Pain (SF‐36 Bodily Pain domain, score 0‐100, lower scores indicate less pain) Summary of findings table ‐ Exercise plus usual pharmacological care vs usual pharmacological care alone | no estimate extracted | 1 study · 31 participants | Very low Downgraded: risk of bias |
Serious adverse events ‐ not reported Summary of findings table ‐ Exercise plus usual pharmacological care vs usual pharmacological care alone | no estimate extracted | NR | No studies |
Withdrawals due to any reason Summary of findings table ‐ Exercise plus usual pharmacological care vs usual pharmacological care alone | RR 0.92 [0.53, 1.6] | 6 studies · 235 participants | Very low Downgraded: risk of bias |
Summary of findings table ‐ Exercise plus usual pharmacological care compared to another intervention (education, joint aids, or relaxation) plus usual pharmacological care for systemic lupus erythematosus
Population: systemic lupus erythematosus
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Fatigue (Fatigue Severity Scale, scores 0‐7, lower scores indicate less fatigue) Summary of findings table ‐ Exercise plus usual pharmacological care vs another intervention (education, joint aids, or relaxation) plus usual pharmacological care | no estimate extracted | 2 studies · 119 participants | Low Downgraded: risk of bias |
Functional capacity (SF‐36 Physical Function domain, score 0‐100, higher scores indicate better functional capacity) Summary of findings table ‐ Exercise plus usual pharmacological care vs another intervention (education, joint aids, or relaxation) plus usual pharmacological care | no estimate extracted | 3 studies · 182 participants | Low Downgraded: risk of bias, imprecision |
Disease activity (SLEDAI scale, score 0‐105, lower scores indicate less disease activity) Summary of findings table ‐ Exercise plus usual pharmacological care vs another intervention (education, joint aids, or relaxation) plus usual pharmacological care | no estimate extracted | 4 studies · 184 participants | Moderate Downgraded: risk of bias |
Pain (VAS Pain scale, score 0‐10, lower scores indicate less pain) Summary of findings table ‐ Exercise plus usual pharmacological care vs another intervention (education, joint aids, or relaxation) plus usual pharmacological care | no estimate extracted | 2 studies · 121 participants | Low Downgraded: risk of bias, imprecision |
Withdrawals due to any reason Summary of findings table ‐ Exercise plus usual pharmacological care vs another intervention (education, joint aids, or relaxation) plus usual pharmacological care | RR 0.89 [0.13, 5.94] | 7 studies · 317 participants | Very low Downgraded: risk of bias, imprecision |
Serious adverse events ‐ not reported Summary of findings table ‐ Exercise plus usual pharmacological care vs another intervention (education, joint aids, or relaxation) plus usual pharmacological care | no estimate extracted | NR | No studies |
Quality of life ‐ not reported Summary of findings table ‐ Exercise plus usual pharmacological care vs another intervention (education, joint aids, or relaxation) plus usual pharmacological care | no estimate extracted | NR | No studies |