Gap finder

Search review questions

Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Every word you type has to appear somewhere in the question, and the closest matches are ranked first.

Limit to evidence status or GRADE (optional)

75,239 questions in 5,342 reviews

current versions
No studies 15,213 · 20.2%Ungraded 10,323 · 13.7%Very low 17,528 · 23.3%Low 17,951 · 23.9%Moderate 11,190 · 14.9%High 3,034 · 4%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

QuestionEffectEvidenceStatus / GRADE
Intervention NR
Participants reporting adverse events · patients with rheumatoid arthritis pain
Opioid therapy for treating rheumatoid arthritis pain (2011) · Cochrane
OR 3.9 [2.31, 6.56]4 studies · 371 participantsLow
Intervention NR
Serious adverse events · patients with rheumatoid arthritis pain
Opioid therapy for treating rheumatoid arthritis pain (2011) · Cochrane
no estimate extracted2 studies · 317 participantsLow
Epinephrine vs placebo
Admissions at enrollment or < 24 hours (outpatients only) · patients with acute viral bronchiolitis
Epinephrine for bronchiolitis (2011) · Cochrane
RR 0.67 [0.5, 0.89]5 studies · 995 participantsModerate
Epinephrine vs steroid
Admissions overall up to 7 days (outpatients only) · patients with acute viral bronchiolitis
Epinephrine for bronchiolitis (2011) · Cochrane
RR 1.08 [0.77, 1.52]1 study · 399 participantsModerate
Epinephrine vs placebo
Admissions overall up to 7 days (outpatients only) · patients with acute viral bronchiolitis
Epinephrine for bronchiolitis (2011) · Cochrane
RR 0.81 [0.63, 1.03]3 studies · 875 participantsLow
Epinephrine vs placebo
Length of stay (inpatients only) · patients with acute viral bronchiolitis
Epinephrine for bronchiolitis (2011) · Cochrane
no estimate extracted2 studies · 292 participantsModerate
Epinephrine vs salbutamol/albuterol
Admissions at enrollment or < 24 hours (outpatients only) · patients with acute viral bronchiolitis
Epinephrine for bronchiolitis (2011) · Cochrane
RR 0.67 [0.41, 1.09]7 studies · 444 participantsModerate
Epinephrine vs salbutamol/albuterol
Admissions overall up to 7 days (outpatients only) · patients with acute viral bronchiolitis
Epinephrine for bronchiolitis (2011) · Cochrane
RR 1.05 [0.71, 1.54]2 studies · 212 participantsModerate
Epinephrine vs salbutamol/albuterol
Length of stay (inpatients only) · patients with acute viral bronchiolitis
Epinephrine for bronchiolitis (2011) · Cochrane
no estimate extracted4 studies · 261 participantsModerate
Epinephrine and steroid vs placebo
Admissions at enrollment or < 24 hours (outpatients only) · patients with acute viral bronchiolitis
Epinephrine for bronchiolitis (2011) · Cochrane
RR 0.64 [0.4, 1.04]1 study · 401 participantsLow
Epinephrine and steroid vs placebo
Admissions overall up to 7 days (outpatients only) · patients with acute viral bronchiolitis
Epinephrine for bronchiolitis (2011) · Cochrane
RR 0.64 [0.44, 0.95]1 study · 400 participantsLow
Epinephrine vs steroid
Admissions (outpatients only) · patients with acute viral bronchiolitis
Epinephrine for bronchiolitis (2011) · Cochrane
RR 1.12 [0.66, 1.88]2 studies · 444 participantsModerate
3,4‐Diaminopyridine vs placebo
Improvement in muscle strength (QMG score) Scale from: 0 to 39 · participants with Lambert‐Eaton myasthenic syndrome
Treatment for Lambert‐Eaton myasthenic syndrome (2011) · Cochrane
no estimate extracted2 studies · 40 participantsModerate
3,4‐Diaminopyridine vs placebo
Improvement in mean CMAP amplitude (mV) · participants with Lambert‐Eaton myasthenic syndrome
Treatment for Lambert‐Eaton myasthenic syndrome (2011) · Cochrane
no estimate extracted4 studies · 94 participantsHigh
3,4‐Diaminopyridine vs placebo
Adverse events · participants with Lambert‐Eaton myasthenic syndrome
Treatment for Lambert‐Eaton myasthenic syndrome (2011) · Cochrane
no estimate extracted4 studies · 42 participantsHigh
Intervention NR
Change in number of mothersaccepting family planningservices · Facilities providing primary health services
Strategies for integrating primary health services in low‐ and middle‐income countries at the point of… (2011) · Cochrane
no estimate extracted16 participantsLow
Intervention NR
Perinatal mortality (deaths per 1000 live and stillbirths) Â · Children under 3 years of age in rural villages
Strategies for integrating primary health services in low‐ and middle‐income countries at the point of… (2011) · Cochrane
no estimate extracted10 participantsVery low
Intervention NR
Neonatal mortality (deaths per 1000 live births) Â · Children under 3 years of age in rural villages
Strategies for integrating primary health services in low‐ and middle‐income countries at the point of… (2011) · Cochrane
no estimate extracted10 participantsVery low
Intervention NR
Infant mortality2 (deaths per 1000 live births) Â · Children under 3 years of age in rural villages
Strategies for integrating primary health services in low‐ and middle‐income countries at the point of… (2011) · Cochrane
no estimate extracted10 participantsVery low
Intervention NR
Utilisation of STI services [Number of visits to STI services per women assessed over a one year period] Â · Women living around truck stops
Strategies for integrating primary health services in low‐ and middle‐income countries at the point of… (2011) · Cochrane
no estimate extracted7 participantsLow
Intervention NR
Women referred to and attended STI services · Women living around truck stops
Strategies for integrating primary health services in low‐ and middle‐income countries at the point of… (2011) · Cochrane
RR 0.547 participantsLow
Intervention NR
Women satisfied with STI services [Number of women interviewed who were satisfied] Â · Women living around truck stops
Strategies for integrating primary health services in low‐ and middle‐income countries at the point of… (2011) · Cochrane
RR 0.847 participantsLow
Intervention NR
Nyamuryekung'e 1997 · Women living around truck stops
Strategies for integrating primary health services in low‐ and middle‐income countries at the point of… (2011) · Cochrane
no estimate extracted1 participantsUngraded
Intervention NR
Change in % of women using family planning  · Couples, women and children in villages and districts
Strategies for integrating primary health services in low‐ and middle‐income countries at the point of… (2011) · Cochrane
no estimate extractedNRLow
Intervention NR
Change in knowledge of family planning  · Couples, women and children in villages and districts
Strategies for integrating primary health services in low‐ and middle‐income countries at the point of… (2011) · Cochrane
no estimate extractedNRLow
Intervention NR
Change in Infant Mortality Rate per 1000 live births1 · Couples, women and children in villages and districts
Strategies for integrating primary health services in low‐ and middle‐income countries at the point of… (2011) · Cochrane
RR 0.53NRLow
Intervention NR
Couples initiating non barrier contraception · Facilities providing primary health services
Strategies for integrating primary health services in low‐ and middle‐income countries at the point of… (2011) · Cochrane
RR 2.39251 participantsModerate
Intervention NR
Perinatal mortality1 (deaths per 1000 live and stillbirths) Â · Couples, women and children in villages and districts
Strategies for integrating primary health services in low‐ and middle‐income countries at the point of… (2011) · Cochrane
no estimate extracted10 participantsVery low
Intervention NR
Neonatal mortality1 (deaths per 1000 live births) Â · Couples, women and children in villages and districts
Strategies for integrating primary health services in low‐ and middle‐income countries at the point of… (2011) · Cochrane
no estimate extracted10 participantsVery low
Intervention NR
Infant mortality1 (deaths per 1000 live births) Â · Couples, women and children in villages and districts
Strategies for integrating primary health services in low‐ and middle‐income countries at the point of… (2011) · Cochrane
no estimate extracted10 participantsVery low
Intervention NR
STI treatment effectiveness Reported as symptoms stopped since STI treatment in past year  · Communities and health centres
Strategies for integrating primary health services in low‐ and middle‐income countries at the point of… (2011) · Cochrane
2.4911980 participantsHigh
Intervention NR
Health seeking behaviour Sought treatment within 3 days of STI symptoms in last year  · Communities and health centres
Strategies for integrating primary health services in low‐ and middle‐income countries at the point of… (2011) · Cochrane
1.1311980 participantsHigh
Intervention NR
STI incidence Urethral or vaginal discharge in last year  · Communities and health centres
Strategies for integrating primary health services in low‐ and middle‐income countries at the point of… (2011) · Cochrane
1.4111980 participantsHigh
Intervention NR
HIV Incidence/1000 person years at risk  · Communities and health centres
Strategies for integrating primary health services in low‐ and middle‐income countries at the point of… (2011) · Cochrane
IRR 1.3611980 participantsHigh
Intervention NR
Gregson 2007 · Communities and health centres
Strategies for integrating primary health services in low‐ and middle‐income countries at the point of… (2011) · Cochrane
no estimate extracted1 participantsUngraded
Intervention NR
Incident pregnancies occurring during a one year · Facilities providing primary health services
Strategies for integrating primary health services in low‐ and middle‐income countries at the point of… (2011) · Cochrane
RR 0.89251 participantsModerate
Intervention NR
Change in % of women accepting family planning methods · Facilities providing primary health services
Strategies for integrating primary health services in low‐ and middle‐income countries at the point of… (2011) · Cochrane
no estimate extracted19 participantsVery low
Intervention NR
Patients offered HIV testing in STI clinics1 Â · Facilities providing primary health services
Strategies for integrating primary health services in low‐ and middle‐income countries at the point of… (2011) · Cochrane
RR 1.359080 participantsModerate
Intervention NR
Patients who received HIV testing in STI clinics1 Â · Facilities providing primary health services
Strategies for integrating primary health services in low‐ and middle‐income countries at the point of… (2011) · Cochrane
RR 1.239080 participantsModerate
Intervention NR
New adult TB patients received HIV counselling in TB clinics2 · Facilities providing primary health services
Strategies for integrating primary health services in low‐ and middle‐income countries at the point of… (2011) · Cochrane
RR 2.69754 participantsHigh
Intervention NR
New adult TB patients received HIV testing in TB clinics2 · Facilities providing primary health services
Strategies for integrating primary health services in low‐ and middle‐income countries at the point of… (2011) · Cochrane
RR 3.12754 participantsHigh
Intervention NR
Leon 2010 2. Pope 2008 · Facilities providing primary health services
Strategies for integrating primary health services in low‐ and middle‐income countries at the point of… (2011) · Cochrane
no estimate extracted1 participantsUngraded
Radioisotopes vs Placebo
Pain relief ‐ Complete relief · patients with metastatic bone pain
Radioisotopes for metastatic bone pain (2011) · Cochrane
RR 2.1 [1.32, 3.35]4 studies · 296 participantsModerate
Radioisotopes vs Placebo
Pain relief ‐ Complete/Partial relief · patients with metastatic bone pain
Radioisotopes for metastatic bone pain (2011) · Cochrane
RR 1.72 [1.13, 2.63]3 studies · 119 participantsModerate
Radioisotopes vs Placebo
Compression of spinal cord · patients with metastatic bone pain
Radioisotopes for metastatic bone pain (2011) · Cochrane
RR 1.1 [0.39, 3.07]2 studies · 270 participantsLow
Radioisotopes vs Placebo
Pain flares · patients with metastatic bone pain
Radioisotopes for metastatic bone pain (2011) · Cochrane
RR 0.74 [0.27, 2.06]2 studies · 270 participantsLow
Radioisotopes vs Placebo
Thrombocytopenia III‐IV · patients with metastatic bone pain
Radioisotopes for metastatic bone pain (2011) · Cochrane
RR 2.21 [0.98, 4.99]4 studies · 313 participantsLow
Radioisotopes vs Placebo
Leucocytopenia III‐IV · patients with metastatic bone pain
Radioisotopes for metastatic bone pain (2011) · Cochrane
RR 5.9 [1.62, 21.47]4 studies · 410 participantsLow
Methylnaltrexone vs placebo
Rescue free laxation within 4 hours · patients with the management of opioid‐induced constipation in palliative care patients
Laxatives or methylnaltrexone for the management of constipation in palliative care patients (2011) · Cochrane
OR 6.95 [3.83, 12.61]2 studies · 287 participantsModerate
Methylnaltrexone vs placebo
Rescue free laxation within 24 hours · patients with the management of opioid‐induced constipation in palliative care patients
Laxatives or methylnaltrexone for the management of constipation in palliative care patients (2011) · Cochrane
OR 5.42 [3.12, 9.41]2 studies · 287 participantsModerate