Cochrane · systematic review · CD003123
Epinephrine for bronchiolitis
Hartling, L, Bialy, LM, Vandermeer, B, et al. · Cochrane Database of Systematic Reviews · 2011 · Cochrane Library
Acute Respiratory InfectionsAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
10
current version
GRADE rated
10
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 3 · 30%Moderate 7 · 70%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Epinephrine versus placebo for acute viral bronchiolitis
Population: patients with acute viral bronchiolitis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Admissions at enrollment or < 24 hours (outpatients only) Epinephrine vs placebo | RR 0.67 [0.5, 0.89] | 5 studies · 995 participants | Moderate |
Admissions overall up to 7 days (outpatients only) Epinephrine vs placebo | RR 0.81 [0.63, 1.03] | 3 studies · 875 participants | Low |
Length of stay (inpatients only) Epinephrine vs placebo | no estimate extracted | 2 studies · 292 participants | Moderate |
Epinephrine versus salbutamol/albuterol for acute viral bronchiolitis
Population: patients with acute viral bronchiolitis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Admissions at enrollment or < 24 hours (outpatients only) Epinephrine vs salbutamol/albuterol | RR 0.67 [0.41, 1.09] | 7 studies · 444 participants | Moderate |
Admissions overall up to 7 days (outpatients only) Epinephrine vs salbutamol/albuterol | RR 1.05 [0.71, 1.54] | 2 studies · 212 participants | Moderate |
Length of stay (inpatients only) Epinephrine vs salbutamol/albuterol | no estimate extracted | 4 studies · 261 participants | Moderate |
Epinephrine and steroid versus placebo for acute viral bronchiolitis
Population: patients with acute viral bronchiolitis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Admissions at enrollment or < 24 hours (outpatients only) Epinephrine and steroid vs placebo | RR 0.64 [0.4, 1.04] | 1 study · 401 participants | Low |
Admissions overall up to 7 days (outpatients only) Epinephrine and steroid vs placebo | RR 0.64 [0.44, 0.95] | 1 study · 400 participants | Low |
Epinephrine versus steroid for acute viral bronchiolitis
Population: patients with acute viral bronchiolitis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Admissions (outpatients only) Epinephrine vs steroid | RR 1.12 [0.66, 1.88] | 2 studies · 444 participants | Moderate |
Admissions overall up to 7 days (outpatients only) Epinephrine vs steroid | RR 1.08 [0.77, 1.52] | 1 study · 399 participants | Moderate |