Gap finder

Search review questions

Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Every word you type has to appear somewhere in the question, and the closest matches are ranked first.

Limit to evidence status or GRADE (optional)

75,239 questions in 5,342 reviews

current versions
No studies 15,213 · 20.2%Ungraded 10,323 · 13.7%Very low 17,528 · 23.3%Low 17,951 · 23.9%Moderate 11,190 · 14.9%High 3,034 · 4%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

QuestionEffectEvidenceStatus / GRADE
Motivational interviewing vs control
Drug abuse Self reported use of marijuana · patients with Improving outcomes in youth living with HIV
Motivational interviewing for improving outcomes in youth living with HIV (2012) · Cochrane
OR 1.23 [0.57, 2.63]1 study · 143 participantsModerate
Motivational interviewing vs control
Alcohol abuse Self reported alcohol use · patients with Improving outcomes in youth living with HIV
Motivational interviewing for improving outcomes in youth living with HIV (2012) · Cochrane
OR 0.58 [0.3, 1.12]1 study · 143 participantsModerate
Multivitamins vs no multivitamins
Birthweight Standard beam balance to nearest 10g · Pregnant and lactating women with HIV
Micronutrient supplementation in pregnant women with HIV infection (2012) · Cochrane
no estimate extracted1 study · 800 participantsModerate
Intervention NR
Preterm < 37 wks · Pregnant women with HIV infection
Micronutrient supplementation in pregnant women with HIV infection (2012) · Cochrane
RR 1.1 [0.7, 1.76]1 study · 366 participantsModerate
Intervention NR
Perinatal death · Pregnant women with HIV infection
Micronutrient supplementation in pregnant women with HIV infection (2012) · Cochrane
RR 1.36 [0.75, 2.47]1 study · 397 participantsModerate
Intervention NR
Birth weight (g) Standard balance beam to within 10g after birth · Pregnant women with HIV infection
Micronutrient supplementation in pregnant women with HIV infection (2012) · Cochrane
no estimate extracted1 study · 358 participantsModerate
Intervention NR
Mean change in Log10viral load at 6 weeks postpartum PCR Roche Amplicor version 1.5kit · Pregnant women with HIV infection
Micronutrient supplementation in pregnant women with HIV infection (2012) · Cochrane
no estimate extracted1 study · 100 participantsLow
Intervention NR
Overall weight gain during pregnancy Calibrated balance beam scale to the nearest 100g · Pregnant women with HIV infection
Micronutrient supplementation in pregnant women with HIV infection (2012) · Cochrane
no estimate extracted1 study · 376 participantsModerate
Intervention NR
Birth weight Standard mechanical scale to nearest 50g · Pregnant women with HIV infection
Micronutrient supplementation in pregnant women with HIV infection (2012) · Cochrane
no estimate extracted1 study · 842 participantsModerate
Intervention NR
Low birth weight < 2500 g Standard mechanical scale to nearest 50g · Pregnant women with HIV infection
Micronutrient supplementation in pregnant women with HIV infection (2012) · Cochrane
RR 0.68 [0.47, 0.98]1 study · 842 participantsModerate
Intervention NR
Preterm birth < 37 weeks Gestational age was based on date of last menstrual period and was obtained at baseline · Pregnant women with HIV infection
Micronutrient supplementation in pregnant women with HIV infection (2012) · Cochrane
RR 1.01 [0.74, 1.37]1 study · 842 participantsModerate
Intervention NR
Perinatal death Death between 28 weeks gestation and 1 week after delivery · Pregnant women with HIV infection
Micronutrient supplementation in pregnant women with HIV infection (2012) · Cochrane
RR 1.35 [0.85, 2.13]1 study · 881 participantsModerate
Intervention NR
Progression to Hb < 8.6g/dL AcT Diff II Analyzer (Beckman Coulter) · Pregnant women with HIV infection
Micronutrient supplementation in pregnant women with HIV infection (2012) · Cochrane
RR 0.63 [0.23, 1.73]1 study · 467 participantsModerate
Multivitamins vs no multivitamins
Birth weight < 2500g Standard beam balance to nearest 10g · Pregnant and lactating women with HIV
Micronutrient supplementation in pregnant women with HIV infection (2012) · Cochrane
RR 0.55 [0.38, 0.81]1 study · 800 participantsModerate
Intervention NR
Change in viral load · Pregnant women with HIV infection
Micronutrient supplementation in pregnant women with HIV infection (2012) · Cochrane
no estimate extracted438 participantsUngraded
Intervention NR
Maternal mortality · Pregnant women with HIV infection
Micronutrient supplementation in pregnant women with HIV infection (2012) · Cochrane
RR 1 [0.51, 1.97]1 study · 913 participantsModerate
Intervention NR
Birth weight (grammes) Standard balance beam to nearest 10g · Pregnant women with HIV infection
Micronutrient supplementation in pregnant women with HIV infection (2012) · Cochrane
no estimate extracted1 study · 1000 participantsModerate
Intervention NR
Birth weight < 2 500g Standard balance beam to nearest 10g · Pregnant women with HIV infection
Micronutrient supplementation in pregnant women with HIV infection (2012) · Cochrane
RR 1.13 [0.79, 1.61]1 study · 1000 participantsModerate
Intervention NR
Preterm birth < 37 weeks Gestational age based on the date of last menstrual period · Pregnant women with HIV infection
Micronutrient supplementation in pregnant women with HIV infection (2012) · Cochrane
RR 1.04 [0.81, 1.35]1 study · 1030 participantsModerate
Intervention NR
Small‐for‐gestational‐age Gestational age based on last menstrual period · Pregnant women with HIV infection
Micronutrient supplementation in pregnant women with HIV infection (2012) · Cochrane
RR 1.24 [0.9, 1.71]1 study · 972 participantsModerate
Intervention NR
Perinatal death · Pregnant women with HIV infection
Micronutrient supplementation in pregnant women with HIV infection (2012) · Cochrane
RR 0.77 [0.48, 1.23]1 study · 1115 participantsModerate
Intervention NR
Haemoglobin < 11g/dL within 10 weeks of delivery (dichotomous) CBC5 Coulter Counter · Pregnant women with HIV infection
Micronutrient supplementation in pregnant women with HIV infection (2012) · Cochrane
RR 0.94 [0.67, 1.32]1 study · 272 participantsLow
Intervention NR
Mean viral load (log10) within 10 weeks of delivery Roche Amplicor HIV‐1 monitor test version 1.5 assay · Pregnant women with HIV infection
Micronutrient supplementation in pregnant women with HIV infection (2012) · Cochrane
no estimate extracted1 study · 174 participantsLow
Multivitamins vs no multivitamins
Preterm birth < 37 weeks Gestational age was determined using date of last menstrual period obtained at randomisation · Pregnant and lactating women with HIV
Micronutrient supplementation in pregnant women with HIV infection (2012) · Cochrane
RR 0.86 [0.68, 1.1]1 study · 888 participantsModerate
Multivitamins vs no multivitamins
Small‐for‐gestational‐age Gestational age was determined using date of last menstrual period obtained at randomisation · Pregnant and lactating women with HIV
Micronutrient supplementation in pregnant women with HIV infection (2012) · Cochrane
RR 0.57 [0.4, 0.83]1 study · 768 participantsModerate
Multivitamins vs no multivitamins
Foetal death (stillbirth and miscarriage) · Pregnant and lactating women with HIV
Micronutrient supplementation in pregnant women with HIV infection (2012) · Cochrane
RR 0.61 [0.39, 0.94]1 study · 1021 participantsModerate
Multivitamins vs no multivitamins
Maternal change in mean Haemoglobin from baseline to 6 weeks post‐partum CBC5 Coulter Counter · Pregnant and lactating women with HIV
Micronutrient supplementation in pregnant women with HIV infection (2012) · Cochrane
no estimate extracted1 study · 1021 participantsModerate
Multivitamins vs no multivitamins
Maternal change in mean CD4 from baseline to 6 weeks post‐partum FACScount system (Becton‐Dickinson) · Pregnant and lactating women with HIV
Micronutrient supplementation in pregnant women with HIV infection (2012) · Cochrane
no estimate extracted1 study · 516 participantsLow
Intervention NR
Mean change in Haemoglobin at 6 weeks post partum CBC5 Coulter Counter · Pregnant women with HIV infection
Micronutrient supplementation in pregnant women with HIV infection (2012) · Cochrane
no estimate extracted1 study · 357 participantsModerate
Intervention NR
Low birth weight < 2500g Standard balance beam to within 10g after birth · Pregnant women with HIV infection
Micronutrient supplementation in pregnant women with HIV infection (2012) · Cochrane
RR 1.06 [0.58, 1.93]1 study · 358 participantsModerate
Mobile phone text messages vs standard care
Viral load suppression at 52 weeks · Patients with HIV infection, on ART
Mobile phone text messaging for promoting adherence to antiretroviral therapy in patients with HIV infection (2012) · Cochrane
RR 0.83 [0.69, 0.99]1 study · 538 participantsHigh
Intervention NR
ART adherence at 48 weeks: Weekly vs. daily messages (overall) · Patients with HIV infection, on ART
Mobile phone text messaging for promoting adherence to antiretroviral therapy in patients with HIV infection (2012) · Cochrane
RR 0.79 [0.64, 0.99]1 study · 289 participantsLow
Intervention NR
ART adherence at 48 weeks: Short vs. long messages (overall) · Patients with HIV infection, on ART
Mobile phone text messaging for promoting adherence to antiretroviral therapy in patients with HIV infection (2012) · Cochrane
RR 1.01 [0.81, 1.25]1 study · 289 participantsLow
Intervention NR
Very few events. · Patients with HIV infection, on ART
Mobile phone text messaging for promoting adherence to antiretroviral therapy in patients with HIV infection (2012) · Cochrane
no estimate extracted1 participantsUngraded
Mobile phone text messages vs standard care
ART adherence at 48‐52 weeks: Text messages vs. standard care (overall) · Patients with HIV infection, on ART
Mobile phone text messaging for promoting adherence to antiretroviral therapy in patients with HIV infection (2012) · Cochrane
RR 0.82 [0.72, 0.94]2 studies · 966 participantsHigh
Mobile phone text messages vs standard care
ART adherence at 48‐52 weeks: Weekly text messages vs. standard care (overall) · Patients with HIV infection, on ART
Mobile phone text messaging for promoting adherence to antiretroviral therapy in patients with HIV infection (2012) · Cochrane
RR 0.78 [0.68, 0.89]2 studies · 898 participantsHigh
Mobile phone text messages vs standard care
ART adherence at 48‐52 weeks: Short weekly messages vs. standard care · Patients with HIV infection, on ART
Mobile phone text messaging for promoting adherence to antiretroviral therapy in patients with HIV infection (2012) · Cochrane
RR 0.77 [0.66, 0.9]2 studies · 750 participantsHigh
Mobile phone text messages vs standard care
ART adherence at 48 weeks: Long weekly messages vs. standard care · Patients with HIV infection, on ART
Mobile phone text messaging for promoting adherence to antiretroviral therapy in patients with HIV infection (2012) · Cochrane
RR 0.79 [0.6, 1.04]1 study · 213 participantsLow
Mobile phone text messages vs standard care
ART adherence at 48 weeks: Short daily messages vs. standard care · Patients with HIV infection, on ART
Mobile phone text messaging for promoting adherence to antiretroviral therapy in patients with HIV infection (2012) · Cochrane
RR 1 [0.79, 1.27]1 study · 209 participantsLow
Mobile phone text messages vs standard care
ART adherence at 48 weeks: Long daily messages vs. standard care · Patients with HIV infection, on ART
Mobile phone text messaging for promoting adherence to antiretroviral therapy in patients with HIV infection (2012) · Cochrane
RR 0.98 [0.77, 1.24]1 study · 211 participantsLow
Mobile phone text messages vs standard care
Very few events. · Patients with HIV infection, on ART
Mobile phone text messaging for promoting adherence to antiretroviral therapy in patients with HIV infection (2012) · Cochrane
no estimate extracted1 participantsUngraded
Intervention NR
ART adherence at 48 weeks: Short weekly messages vs. long weekly messages · Patients with HIV infection, on ART
Mobile phone text messaging for promoting adherence to antiretroviral therapy in patients with HIV infection (2012) · Cochrane
RR 0.98 [0.7, 1.39]1 study · 147 participantsLow
α‐FLUPENTHIXOL vs PLACEBO or β‐FLUPENTHIXOL
Global state: clinically important change in global state needing additional medication ‐ chlorpromazine · patients with schizophrenia
Flupenthixol versus placebo for schizophrenia (2012) · Cochrane
OR 0.19 [0.05, 0.71]1 study · 45 participantsVery low
α‐FLUPENTHIXOL vs PLACEBO or β‐FLUPENTHIXOL
Mental state and behaviour: clinically important change in general mental state and behaviour · patients with schizophrenia
Flupenthixol versus placebo for schizophrenia (2012) · Cochrane
no estimate extracted1 study · 45 participantsUngraded
α‐FLUPENTHIXOL vs PLACEBO or β‐FLUPENTHIXOL
Adverse effects/events: incidence of adverse effects/events · patients with schizophrenia
Flupenthixol versus placebo for schizophrenia (2012) · Cochrane
no estimate extracted0 studies · 0 participantsUngraded
α‐FLUPENTHIXOL vs PLACEBO or β‐FLUPENTHIXOL
Service outcomes: hospital admission · patients with schizophrenia
Flupenthixol versus placebo for schizophrenia (2012) · Cochrane
no estimate extracted0 studies · 0 participantsUngraded
α‐FLUPENTHIXOL vs PLACEBO or β‐FLUPENTHIXOL
General functioning: Poor social functioning ‐ modified Cooper's ratings5,6 · patients with schizophrenia
Flupenthixol versus placebo for schizophrenia (2012) · Cochrane
RR 1.33 [0.91, 1.96]1 study · 45 participantsVery low
α‐FLUPENTHIXOL vs PLACEBO or β‐FLUPENTHIXOL
Satisfaction with treatment: satisfaction with care for recipients of care or careers · patients with schizophrenia
Flupenthixol versus placebo for schizophrenia (2012) · Cochrane
no estimate extracted0 studies · 0 participantsUngraded
α‐FLUPENTHIXOL vs PLACEBO or β‐FLUPENTHIXOL
Economic outcomes: direct costs · patients with schizophrenia
Flupenthixol versus placebo for schizophrenia (2012) · Cochrane
no estimate extracted0 studies · 0 participantsUngraded
Early routine ERCP strategy vs early conservative management with or without delayed or selective ERCP strategy
All‐cause mortality, ITT analysis · patients with unselected patients with acute gallstone pancreatitis
Early routine endoscopic retrograde cholangiopancreatography strategy versus early conservative management… (2012) · Cochrane
RR 0.74 [0.18, 3.03]5 studies · 644 participantsLow