Cochrane · systematic review · CD009755
Micronutrient supplementation in pregnant women with HIV infection
Siegfried, N, Irlam, JH, Visser, ME, et al. · Cochrane Database of Systematic Reviews · 2012 · Cochrane Library
HIV/AIDSAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
28
current version
GRADE rated
27
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 1 · 3.6%Very low 0 · 0%Low 4 · 14.3%Moderate 23 · 82.1%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Multivitamins versus no multivitamins in pregnant and lactating women with HIV
Population: Pregnant and lactating women with HIV
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Birthweight Standard beam balance to nearest 10g Multivitamins vs no multivitamins | no estimate extracted | 1 study · 800 participants | Moderate |
Birth weight < 2500g Standard beam balance to nearest 10g Multivitamins vs no multivitamins | RR 0.55 [0.38, 0.81] | 1 study · 800 participants | Moderate |
Preterm birth < 37 weeks Gestational age was determined using date of last menstrual period obtained at randomisation Multivitamins vs no multivitamins | RR 0.86 [0.68, 1.1] | 1 study · 888 participants | Moderate |
Small‐for‐gestational‐age Gestational age was determined using date of last menstrual period obtained at randomisation Multivitamins vs no multivitamins | RR 0.57 [0.4, 0.83] | 1 study · 768 participants | Moderate |
Foetal death (stillbirth and miscarriage) Multivitamins vs no multivitamins | RR 0.61 [0.39, 0.94] | 1 study · 1021 participants | Moderate |
Maternal change in mean Haemoglobin from baseline to 6 weeks post‐partum CBC5 Coulter Counter Multivitamins vs no multivitamins | no estimate extracted | 1 study · 1021 participants | Moderate |
Maternal change in mean CD4 from baseline to 6 weeks post‐partum FACScount system (Becton‐Dickinson) Multivitamins vs no multivitamins | no estimate extracted | 1 study · 516 participants | Low Downgraded: risk of bias |
Zinc in pregnant women with HIV infection
Population: Pregnant women with HIV infection
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mean change in Haemoglobin at 6 weeks post partum CBC5 Coulter Counter | no estimate extracted | 1 study · 357 participants | Moderate Downgraded: imprecision, indirectness |
Low birth weight < 2500g Standard balance beam to within 10g after birth | RR 1.06 [0.58, 1.93] | 1 study · 358 participants | Moderate Downgraded: imprecision, indirectness |
Preterm < 37 wks | RR 1.1 [0.7, 1.76] | 1 study · 366 participants | Moderate Downgraded: imprecision, indirectness |
Perinatal death | RR 1.36 [0.75, 2.47] | 1 study · 397 participants | Moderate Downgraded: imprecision, indirectness |
Birth weight (g) Standard balance beam to within 10g after birth | no estimate extracted | 1 study · 358 participants | Moderate Downgraded: imprecision, indirectness |
Mean change in Log10viral load at 6 weeks postpartum PCR Roche Amplicor version 1.5kit | no estimate extracted | 1 study · 100 participants | Low Downgraded: imprecision |
Overall weight gain during pregnancy Calibrated balance beam scale to the nearest 100g | no estimate extracted | 1 study · 376 participants | Moderate Downgraded: imprecision, indirectness |
Selenium for Pregnant women with HIV infection
Population: Pregnant women with HIV infection
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Birth weight Standard mechanical scale to nearest 50g | no estimate extracted | 1 study · 842 participants | Moderate Downgraded: imprecision |
Low birth weight < 2500 g Standard mechanical scale to nearest 50g | RR 0.68 [0.47, 0.98] | 1 study · 842 participants | Moderate Downgraded: imprecision |
Preterm birth < 37 weeks Gestational age was based on date of last menstrual period and was obtained at baseline | RR 1.01 [0.74, 1.37] | 1 study · 842 participants | Moderate Downgraded: imprecision |
Perinatal death Death between 28 weeks gestation and 1 week after delivery | RR 1.35 [0.85, 2.13] | 1 study · 881 participants | Moderate Downgraded: imprecision |
Progression to Hb < 8.6g/dL AcT Diff II Analyzer (Beckman Coulter) | RR 0.63 [0.23, 1.73] | 1 study · 467 participants | Moderate Downgraded: imprecision, indirectness |
Change in viral load | no estimate extracted | 438 participants | Ungraded |
Maternal mortality | RR 1 [0.51, 1.97] | 1 study · 913 participants | Moderate |
Multiple RDA multivitamins for Pregnant women with HIV infection
Population: Pregnant women with HIV infection
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Birth weight (grammes) Standard balance beam to nearest 10g | no estimate extracted | 1 study · 1000 participants | Moderate Downgraded: imprecision, indirectness |
Birth weight < 2 500g Standard balance beam to nearest 10g | RR 1.13 [0.79, 1.61] | 1 study · 1000 participants | Moderate Downgraded: imprecision, indirectness |
Preterm birth < 37 weeks Gestational age based on the date of last menstrual period | RR 1.04 [0.81, 1.35] | 1 study · 1030 participants | Moderate Downgraded: imprecision, indirectness |
Small‐for‐gestational‐age Gestational age based on last menstrual period | RR 1.24 [0.9, 1.71] | 1 study · 972 participants | Moderate Downgraded: imprecision, indirectness |
Perinatal death | RR 0.77 [0.48, 1.23] | 1 study · 1115 participants | Moderate Downgraded: imprecision, indirectness |
Haemoglobin < 11g/dL within 10 weeks of delivery (dichotomous) CBC5 Coulter Counter | RR 0.94 [0.67, 1.32] | 1 study · 272 participants | Low Downgraded: imprecision, indirectness |
Mean viral load (log10) within 10 weeks of delivery Roche Amplicor HIV‐1 monitor test version 1.5 assay | no estimate extracted | 1 study · 174 participants | Low Downgraded: imprecision, indirectness |