Alpha diversity (Chao1, Observed, Shannon) · Adults providing oral (saliva/supragingival plaque) 16S rRNA microbiome samples
In adults, caries-vs-health alpha diversity differed for the Shannon index but not Chao1/Observed (ungraded).
1 finding from 1 review
Enamel caries proportion · European adolescents aged 12 years
Pooled enamel caries proportion was 0.52 (I² = 100.0%).
1 finding from 1 review
Dental development / dental age (mineralization chronology) · Children or adolescents
No significant overall difference in dental development between CLWH on ART and healthy controls (three studies, narrative synthesis).
1 finding from 1 review
Marginal adaptation (unacceptable marginal adaptation) · Patients with permanent dentition in need of restorations (all cavity types: Black's Class I, II, V, and non-carious cervical lesions)
Across follow-up periods, there was no statistically significant difference in unacceptable marginal adaptation between GIC and resin composite restorations.
6 findings from 1 review
Secondary caries and marginal adaptation of ion-releasing versus resin composite restorations: a systematic review and… 2022 All outcomes1 year, 18 months to 2 years, and 3 years · University, private practice, primary school, and multicenter settings · All types of cavities
RD 0.01 [-0.01, 0.03]
9 studies · 2725 participants
GRADE not reported
Secondary caries and marginal adaptation of ion-releasing versus resin composite restorations: a systematic review and… 2022 All outcomes3 years · Permanent dentition; university (majority), school, and private-practice settings across multiple countries (Turkey, Brazil, Sweden, India, Vietnam, Belgium, Germany, etc.)
RD 0.00 [-0.02, 0.02]
3 studies · 321 participants
Low
Secondary caries and marginal adaptation of ion-releasing versus resin composite restorations: a systematic review and… 2022 All outcomes3 years · University, private practice, primary school, and multicenter settings · All types of cavities
RD 0.00 [-0.02, 0.02]
3 studies · 321 participants
Low
Show 3 more findings
Secondary caries and marginal adaptation of ion-releasing versus resin composite restorations: a systematic review and… 2022 All outcomes1 year · University, private practice, primary school, and multicenter settings · All types of cavities
RD 0.01 [-0.02, 0.03]
9 studies · 1386 participants
Low
Secondary caries and marginal adaptation of ion-releasing versus resin composite restorations: a systematic review and… 2022 All outcomes18 months-2 years · Permanent dentition; university (majority), school, and private-practice settings across multiple countries (Turkey, Brazil, Sweden, India, Vietnam, Belgium, Germany, etc.)
RD 0.03 [-0.02, 0.08]
7 studies · 1018 participants
Low
Secondary caries and marginal adaptation of ion-releasing versus resin composite restorations: a systematic review and… 2022 All outcomes1 year · Permanent dentition; university (majority), school, and private-practice settings across multiple countries (Turkey, Brazil, Sweden, India, Vietnam, Belgium, Germany, etc.)
RD 0.01 [-0.02, 0.03]
9 studies · 1386 participants
Low
Dental caries prevalence · European adolescents aged 12–19 years
Caries prevalence at the dentine threshold was about 56% (pooled 0.56, 95% CI 0.43 to 0.68; 15 studies; not GRADE-rated).
7 findings from 1 review
Prevalence 0.56 [0.43, 0.68]
15 studies
GRADE not reported
Prevalence 0.49 [0.32, 0.67]
9 studies
GRADE not reported
Prevalence 0.57 [0.32, 0.81]
6 studies
GRADE not reported
Show 4 more findings
Overall success (composite of clinical and radiographic success) · Human permanent teeth with asymptomatic irreversible pulpitis due to carious pulp exposure
In asymptomatic irreversible pulpitis, pooled pulpotomy success was 91.3% (95% CI 80-96.5%); ungraded.
1 finding from 1 review
Dental caries prevalence · European adolescents aged 12–19 years
Enamel-threshold caries prevalence in subgroup 'Region: non-Scandinavian' was 0.74 (95% CI 0.53 to 0.96; 11 studies).
11 findings from 1 review
Show 8 more findings
Prevalence 0.74 [0.57, 0.90]
17 studies
GRADE not reported
Prevalence 0.76 [0.65, 0.87]
11 studies
GRADE not reported
Prevalence 0.83 [0.75, 0.89]
7 studies
GRADE not reported
Prevalence 0.77 [0.65, 0.89]
22 studies · 84512 participants
GRADE not reported
Prevalence 0.74 [0.53, 0.96]
11 studies
GRADE not reported
Prevalence 0.72 [0.54, 0.89]
15 studies
GRADE not reported
Prevalence 0.90 [0.85, 0.94]
7 studies
GRADE not reported
Prevalence 0.78 [0.70, 0.87]
10 studies
GRADE not reported
Overall success (composite of clinical and radiographic success) · Human permanent teeth with irreversible pulpitis due to carious pulp exposure
Biodentine had a significantly higher pulpotomy success rate than CEM (indirect comparison; numeric estimate not available); ungraded.
1 finding from 1 review
Overall success (composite of clinical and radiographic success) · Human permanent teeth with irreversible pulpitis due to carious pulp exposure
MTA and CEM did not differ significantly in pulpotomy success (indirect comparison); ungraded.
1 finding from 1 review
Dental caries prevalence · European adolescents aged 12 years
Pooled caries prevalence was 0.69 (I² = 100.0%).
1 finding from 1 review
Early childhood caries experience (mean dmft) · Children in the primary dentition with non-syndromic cleft lip and/or palate (CL/P) and comparable children without CL/P
In the combined primary and mixed dentition, there was no evidence of a difference in caries experience between children with and without CL/P (SMD 0.09, 95% CI -0.59-0.76; 5 studies; ungraded).
4 findings from 1 review
Caries in children with and without orofacial clefting: A systematic review and meta-analysis. 2022 All outcomesChildren with CL/P and comparable non-CL/P children across 12 countries (India, Brazil, China, Sweden, UK, USA, Germany, Greece, Ireland, Netherlands, Jordan, Thailand); studies published 1989-2021 · Primary and mixed dentition
SMD 0.09 [-0.59, 0.76]
5 studies · 708 participants
GRADE not reported
Caries in children with and without orofacial clefting: A systematic review and meta-analysis. 2022 All outcomesChildren with CL/P and comparable non-CL/P children across 12 countries (India, Brazil, China, Sweden, UK, USA, Germany, Greece, Ireland, Netherlands, Jordan, Thailand); studies published 1989-2021 · Mixed dentition
SMD 1.74 [0.24, 3.25]
4 studies · 789 participants
GRADE not reported
Caries in children with and without orofacial clefting: A systematic review and meta-analysis. 2022 All outcomesChildren with CL/P and comparable non-CL/P children across 12 countries (India, Brazil, China, Sweden, UK, USA, Germany, Greece, Ireland, Netherlands, Jordan, Thailand); studies published 1989-2021 · Primary dentition
SMD 0.27 [0.06, 0.49]
10 studies · 2366 participants
GRADE not reported
Show 1 more finding
HIV-related oral lesions · Children living with HIV receiving ART
One reported study did not show a clear difference in HIV-related oral lesions for children with CD4+ T-cell counts below 250 cells/mm3.
2 findings from 1 review
OR 1.916 [0.613, 2.513]
1 study
GRADE not reported
OR 1.999 [0.129, 3.688]
1 study
GRADE not reported
Immediate bond strength (MPa) · Dental adhesives/resin composite bonded to dentin (in vitro), sound or caries-affected
Prior SDF application significantly reduces the immediate bond strength of adhesives to dentin overall (MD 7.12 MPa favoring untreated dentin, 95% CI 1.38 to 12.85; ungraded), with very high heterogeneity (I2=98%).
1 finding from 1 review
Oral hygiene measured by mean gingival scores · Primary school children (aged 3-16 years) attending primary school in low- and middle-income countries (LMICs)
The effect of school-based interventions on gingival scores is uncertain and not statistically significant (SMD 0.12; very low certainty).
1 finding from 1 review
Dental caries · Primary school children (aged 3-16 years) attending primary school in low- and middle-income countries (LMICs)
Among children aged 6-8 years, DMFT scores were significantly reduced (SMD -0.11); subgroup not separately GRADE-rated.
8 findings from 1 review
Effectiveness of primary school-based interventions in improving oral health of children in low- and middle-income… 2022 All outcomesPost-intervention; follow-up varied across studies (interventions ranged from <2 years to >=2 years and longer) · Primary schools in low- and middle-income countries (Southeast Asia, Africa, the Americas, Europe, eastern Mediterranean) · Age 6-8 years
SMD -0.11 [-0.17, -0.04]
Studies not reported
GRADE not reported
Effectiveness of primary school-based interventions in improving oral health of children in low- and middle-income… 2022 All outcomesPost-intervention; follow-up varied across studies (interventions ranged from <2 years to >=2 years and longer) · Primary schools in low- and middle-income countries (Southeast Asia, Africa, the Americas, Europe, eastern Mediterranean) · <=3 intervention activities
SMD -0.58 [-1.62, 0.45]
Studies not reported
GRADE not reported
Effectiveness of primary school-based interventions in improving oral health of children in low- and middle-income… 2022 All outcomes<2 years · Primary schools in low- and middle-income countries (Southeast Asia, Africa, the Americas, Europe, eastern Mediterranean) · Intervention duration <2 years
SMD 0.01 [-0.16, 0.18]
3 studies
GRADE not reported
Show 5 more findings
Recurrent caries (crowns free of recurrent caries) · Children with primary (deciduous) teeth requiring full-coverage crown restoration
Recurrent caries did not differ between zirconia crowns and other restorations at 6 months (RR 1.00, 95% CI 0.97 to 1.03; 2 studies; not GRADE-rated).
2 findings from 1 review
Acute necrotising ulcerative gingivitis prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
Acute necrotising ulcerative gingivitis was significantly more prevalent in treatment-naive CLWH than in those on ART (very low certainty).
1 finding from 1 review
OR 0.00 [0.00, 0.02]
Studies not reported
Very low
Annual increment in DMFS (D3) · Primary school children (aged 3-16 years) attending primary school in low- and middle-income countries (LMICs)
Oral-health-education interventions significantly reduced net increment in DMFS (SMD -1.05); no significant subgroup difference vs other interventions (P=0.74).
5 findings from 1 review
Effectiveness of primary school-based interventions in improving oral health of children in low- and middle-income… 2022 All outcomesPost-intervention; follow-up varied across studies (interventions ranged from <2 years to >=2 years and longer) · Primary schools in low- and middle-income countries (Southeast Asia, Africa, the Americas, Europe, eastern Mediterranean) · Intervention type: oral health education
SMD -1.05 [-2.03, -0.08]
3 studies
GRADE not reported
Effectiveness of primary school-based interventions in improving oral health of children in low- and middle-income… 2022 All outcomesPost-intervention; follow-up varied across studies (interventions ranged from <2 years to >=2 years and longer) · Primary schools in low- and middle-income countries (Southeast Asia, Africa, the Americas, Europe, eastern Mediterranean) · WHO health-promoting-schools framework
SMD -0.57 [-1.56, 0.42]
2 studies
GRADE not reported
Effectiveness of primary school-based interventions in improving oral health of children in low- and middle-income… 2022 All outcomesPost-intervention; follow-up varied across studies (interventions ranged from <2 years to >=2 years and longer) · Primary schools in low- and middle-income countries (Southeast Asia, Africa, the Americas, Europe, eastern Mediterranean) · Non-WHO-framework interventions
SMD -1.88 [-3.15, -0.60]
Studies not reported
GRADE not reported
Show 2 more findings
Recurrent oral ulcerations (WHO clinical stage 2) · Children or adolescents
CLWH on ART had significantly higher prevalence of recurrent oral ulcerations than healthy controls (pooled OR 6.83, 95% CI 1.18 to 39.53).
1 finding from 1 review
Caries distribution (individual/tooth/surface level) · European adolescents aged 12–19 years
Caries distribution was skewed at individual, tooth and surface levels and too heterogeneous to meta-analyze (narrative synthesis of 11 studies; not GRADE-rated).
1 finding from 1 review
No meta-analysis possible; caries distribution reported narratively from 11 studies as skewed at individual, tooth and surface levels, changing with age at tooth and surface level (Results – Caries distribution).
11 studies
GRADE not reported